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DOI: https://doi.org/10.17728/jaft.20621

The Potential of Polysaccharides from Various Plants as Constipation Treatment

*Yuli Perwita Sari orcid scopus  -  Department of Agricultural Product Technology, Universitas Mercu Buana Yogyakarta, Yogyakarta 55753, Indonesia
Dipta Bthari Candraruna  -  Department of Food and Agriculture Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Open Access Copyright 2023 Journal of Applied Food Technology

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Abstract
Constipation is one of the disorders of Irritable Bowel Syndrome (IBS). Lack of consumption of water and food with fiber are some of the causes of constipation. Treatment for constipation patients can be solved by administering laxatives through drugs (pharmaceuticals) or using polysaccharide parts from plants. There are at least three types of laxatives: bulking agents (having the ability to bulk up), osmotic agents, and stimulants. Polysaccharides can be sourced from whole or some parts of the plants. Each type of plant has different polysaccharide components, and their effects on constipation treatment are also specific. The study aimed to review the mechanisms of polysaccharides from various plants parts and explained the misconception of polysaccharide intake as a laxative agent in treating constipation. This review was based on literature studies related to polysaccharides from plants materials and their effects as laxatives in experimental animals. The review found that these polysaccharides have a positive effect as a laxative or digestive aid. In general, polysaccharides from several plants were extracted and characterized to be used as anti-constipation test materials. These polysaccharides can help increase the amount, weight, and water content of feces (bulk), increase peristalsis, speed up gastric emptying and transit time, as well as restore hormones that work in movement in the digestive tract, and improve the condition of the distal colon tissue. These studies are still limited to using animals as experimental test material in polysaccharides to treat constipation. In addition, it has the potential to be further explored regarding the possibility of clinical trials of polysaccharides in humans as laxatives.
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Keywords: constipation; laxative; polysaccharide; plants
Funding: Ministry of Education, Culture, Research and Technology; Universitas Gadjah Mada and Universitas Mercu Buana Yogyakarta

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Section: Summary Research
Language : EN
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  1. Arnaud, M.J. 2003. Mild dehydration: a risk factor of constipation?. European Journal of Clinical Nutrition 57(S2): S88–S95. DOI: 10.1038/sj.ejcn.1601907
  2. Belsey, J., Greenfield, S., Candy, D., Geraint, M. 2010. Systematic review: impact of constipation on quality of life in adults and children. Alimentary Pharmacology & Therapeutics 31(9): 938–949. DOI: 10.1111/j.1365-2036.2010.04273.x
  3. Brownlee, I.A. 2011. The physiological roles of dietary fibre. Food Hydrocolloids 25(2): 238–250. Elsevier Ltd. DOI: 10.1016/j.foodhyd.2009.11.013
  4. Calleros, L., Sanchez-Hernandez, I., Baquero, P., Toro, M.J., Chiloeches, A. 2009. Oncogenic Ras, but not V600EB-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. Carcinogenesis 30(10): 1670–1677. DOI: 10.1093/carcin/bgp188
  5. Chen, D., Chen, G., Ding, Y., Wan, P., Peng, Y., Chen, C., Ye, H., et al. 2019. Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression. Journal of Functional Foods 61 103470. DOI: 10.1016/j.jff.2019.103470
  6. Cheng, N., Wang, H., Hao, H., Rahman, F.-U., Zhang, Y. 2023. Research progress on polysaccharide components of Cistanche deserticola as potential pharmaceutical agents. European Journal of Medicinal Chemistry 245 114892. DOI: 10.1016/j.ejmech.2022.114892
  7. Cummings, J.H., Bingham, S.A., Heaton, K.W., Eastwood, M.A. 1992. Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology 103(6): 1783–1789. DOI: 10.1016/0016-5085(92)91435-7
  8. Defrees, D.N., Bailey, J. 2017. Irritable Bowel Syndrome Epidemiology, Pathophysiology, Diagnosis, and Treatment. Primary Care Clinics in Office Practice 1–17. Elsevier Inc. DOI: 10.1016/j.pop.2017.07.009
  9. Dey, Y., Mahor, S., Kumar, D., Wanjari, M., Gaidhani, S., Jadhav, A. 2016. Gastrokinetic Activity of Amorphophallus paeoniifolius Tuber in Rats. Journal of Intercultural Ethnopharmacology 5(1): 36. DOI: 10.5455/jice.20151211063819
  10. Dimidi, E., Christodoulides, S., Scott, S.M., Whelan, K. 2017. Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation. Advances in Nutrition 8(3): 484–494. DOI: 10.3945/an.116.014407
  11. Drosopoulos, K.G., Roberts, M.L., Cermak, L., Sasazuki, T., Shirasawa, S., Andera, L., Pintzas, A. 2005. Transformation by Oncogenic RAS Sensitizes Human Colon Cells to TRAIL-induced Apoptosis by Up-regulating Death Receptor 4 and Death Receptor 5 through a MEK-dependent Pathway. Journal of Biological Chemistry 280(24): 22856–22867. DOI: 10.1074/jbc.M412483200
  12. Fu, Z., Han, L., Zhang, P., Mao, H., Zhang, H., Wang, Y., Gao, X., et al. 2020. Cistanche polysaccharides enhance echinacoside absorption in vivo and affect the gut microbiota. International Journal of Biological Macromolecules 149 732–740. DOI: 10.1016/j.ijbiomac.2020.01.216
  13. Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya, M., Mantyh, C., Voss, M., Eubanks, S., et al. 2003. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284(5): R1269–R1276. DOI: 10.1152/ajpregu.00442.2002
  14. Gao, Y., Li, B., Liu, H., Tian, Y., Gu, C., Du, X., Bu, R., et al. 2021. Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis. Aging 13(11): 15320–15335. DOI: 10.18632/aging.203090
  15. Gélinas, P. 2013. Preventing constipation: a review of the laxative potential of food ingredients. International Journal of Food Science & Technology 48(3): 445–467. DOI: 10.1111/j.1365-2621.2012.03207.x
  16. Guan, C., Zhang, Y., Wang, H., Chen, Q., Pang, X., Cui, X., Cheng, Y., et al. 2023. Effects of wheat germ polysaccharides prepared by ultra-high pressure on functional constipation and gut microbiota. Food Bioscience 103347. DOI: 10.1016/j.fbio.2023.103347
  17. Heuvel, E.G.H.M. van den, Wils, D., Pasman, W.J., Bakker, M., Saniez, M.-H., Kardinaal, A.F.M. 2004. Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men. European Journal of Clinical Nutrition 58(7): 1046–1055. DOI: 10.1038/sj.ejcn.1601930
  18. Hond, E. Den, Geypens, B., Ghoos, Y. 2000. Effect of high performance chicory inulin on constipation. Nutrition Research 20(5): 731–736. DOI: 10.1016/S0271-5317(00)00162-7
  19. Hu, J.-L., Nie, S.-P., Min, F.-F., Xie, M.-Y. 2012. Polysaccharide from Seeds of Plantago asiatica L. Increases Short-Chain Fatty Acid Production and Fecal Moisture along with Lowering pH in Mouse Colon. Journal of Agricultural and Food Chemistry 60(46): 11525–11532. DOI: 10.1021/jf302169u
  20. Huang, L., Zhu, Q., Qu, X., Qin, H. 2018. Microbial treatment in chronic constipation. Science China Life Sciences 61(7): 744–752. DOI: 10.1007/s11427-017-9220-7
  21. Jia, Y., Guan, Q., Guo, Y., Du, C. 2012. Reduction of Inflammatory Hyperplasia in the Intestine in Colon Cancer‐prone Mice by Water‐extract of Cistanche deserticola. Phytotherapy Research 26(6): 812–819. DOI: 10.1002/ptr.3637
  22. Jiang, H., Dong, J., Jiang, S., Liang, Q., Zhang, Y., Liu, Z., Ma, C., et al. 2020. Effect of Durio zibethinus rind polysaccharide on functional constipation and intestinal microbiota in rats. Food Research International 136 109316. DOI: 10.1016/j.foodres.2020.109316
  23. Kanai, Y., Clémençon, B., Simonin, A., Leuenberger, M., Lochner, M., Weisstanner, M., Hediger, M.A. 2013. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular Aspects of Medicine 34(2–3): 108–120. DOI: 10.1016/j.mam.2013.01.001
  24. Lee, H.-Y., Kim, J.-H., Jeung, H.-W., Lee, C.-U., Kim, D.-S., Li, B., Lee, G.-H., et al. 2012. Effects of Ficus carica paste on loperamide-induced constipation in rats. Food and Chemical Toxicology 50(3–4): 895–902. DOI: 10.1016/j.fct.2011.12.001
  25. Lee, M.H., Jang, D. IL, Choi, J. 2023. The Assessment of the Skin-Whitening and Anti-Wrinkling Effects of Anemarrhena asphodeloides Bunge Root Extracts and the Identification of Nyasol in a Developed Cream Product. Cosmetics 10(3): 73. MDPI. DOI: 10.3390/cosmetics10030073
  26. Li, X., Liu, Y., Guan, W., Xia, Y., Zhou, Y., Yang, B., Kuang, H. 2019. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats. Journal of Ethnopharmacology 240 111961. DOI: 10.1016/j.jep.2019.111961
  27. Liang, F., Hu, C., He, Z., Pan, Y. 2014. An arabinogalactan from flowers of Chrysanthemum morifolium: structural and bioactivity studies. Carbohydrate Research 387 37–41. DOI: 10.1016/j.carres.2013.09.002
  28. Lim, Y., Jamaluddin, R., Hazizi, A., Chieng, J. 2018. Effects of Synbiotics among Constipated Adults in Serdang, Selangor, Malaysia—A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients 10(7): 824. DOI: 10.3390/nu10070824
  29. Liu, H., Fan, H., Zhang, J., Zhang, S., Zhao, W., Liu, T., Wang, D. 2020. Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don. Food Science and Human Wellness 9(1): 71–79. DOI: 10.1016/j.fshw.2019.12.006
  30. Liu, X., Jian, C., Li, M., Wei, F., Liu, H., Qin, X. 2022. Microbiome-metabolomics deciphers the effects of Cistanche deserticola polysaccharides on aged constipated rats. Food & Function 13(7): 3993–4008. DOI: 10.1039/D2FO00008C
  31. Luan, Y., Mao, D., Guo, A., Cao, Y., Zhou, J., Xiang, F., Xiong, Z. 2019. The effect of Codonopis bulleynana Forest ex Diels on chronically constipated mice. Saudi Journal of Biological Sciences 26(2): 402–412. King Saud University. DOI: 10.1016/j.sjbs.2018.11.009
  32. Luo, D., Qu, C., Lin, G., Zhang, Z., Xie, J., Chen, H., Liang, J., et al. 2017. Character and laxative activity of polysaccharides isolated from Dendrobium officinale. Journal of Functional Foods 34 106–117. DOI: 10.1016/j.jff.2017.04.024
  33. Mancabelli, L., Milani, C., Lugli, G.A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., et al. 2017. Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses. Scientific Reports 7(1): 9879. DOI: 10.1038/s41598-017-10663-w
  34. Marlett, J.A., Kajs, T.M., Fischer, M.H. 2000. An unfermented gel component of psyllium seed husk promotes laxation as a lubricant in humans. The American Journal of Clinical Nutrition 72(3): 784–789. DOI: 10.1093/ajcn/72.3.784
  35. Mayers, J.R., Heiden, M.G. Vander. 2015. Famine versus feast: understanding the metabolism of tumors in vivo. Trends in Biochemical Sciences 40(3): 130–140. DOI: 10.1016/j.tibs.2015.01.004
  36. McRorie, J.W., Chey, W.D. 2016. Fermented Fiber Supplements Are No Better Than Placebo for a Laxative Effect. Digestive Diseases and Sciences 61(11): 3140–3146. DOI: 10.1007/s10620-016-4304-1
  37. McRorie, J.W., McKeown, N.M. 2017. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. Journal of the Academy of Nutrition and Dietetics 117(2): 251–264. DOI: 10.1016/j.jand.2016.09.021
  38. Naik R, S., AP, A., M, P., MS, M. 2021. Flax Seeds ( Linum usitatissimmum): Nutritional composition and health benefits. IP Journal of Nutrition, Metabolism and Health Science 3(2): 35–40. IP Innovative Publication Pvt Ltd. DOI: 10.18231/j.ijnmhs.2020.008
  39. Quigley, E.M.M. 2011. The enteric microbiota in the pathogenesis and management of constipation. Best Practice & Research Clinical Gastroenterology 25(1): 119–126. DOI: 10.1016/j.bpg.2011.01.003
  40. Ramos, C.I., Andrade de Lima, A.F., Grilli, D.G., Cuppari, L. 2015. The Short-Term Effects of Olive Oil and Flaxseed Oil for the Treatment of Constipation in Hemodialysis Patients. Journal of Renal Nutrition 25(1): 50–56. DOI: 10.1053/j.jrn.2014.07.009
  41. Rodriguez Sawicki, L., Bottasso Arias, N.M., Scaglia, N., Falomir Lockhart, L.J., Franchini, G.R., Storch, J., Córsico, B. 2017. FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862(12): 1587–1594. DOI: 10.1016/j.bbalip.2017.09.006
  42. Saito, T., Mizutani, F., Iwanaga, Y., Morikawa, K., Kato, H. 2002. Laxative and Anti-diarrheal Activity of Polycarbophil in Mice and Rats. Japanese Journal of Pharmacology 89(2): 133–141. DOI: 10.1254/jjp.89.133
  43. Singh, K.K., Mridula, D., Rehal, J., Barnwal, P. 2011. Flaxseed: A Potential Source of Food, Feed and Fiber. Critical Reviews in Food Science and Nutrition 51(3): 210–222. DOI: 10.1080/10408390903537241
  44. Slavin, J., Savarino, V., Paredes-Diaz, A., Fotopoulos, G. 2009. A Review of the Role of Soluble Fiber in Health with Specific Reference to Wheat Dextrin. Journal of International Medical Research 37(1): 1–17. DOI: 10.1177/147323000903700101
  45. Soltanian, N., Janghorbani, M. 2018. A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes. Nutrition & Metabolism 15(1): 36. DOI: 10.1186/s12986-018-0273-z
  46. Song, H., Guo, R., Sun, X., Kou, Y., Ma, X., Chen, Y., Song, L., et al. 2023. Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism. Food & Function 14(19): 8734–8746. DOI: 10.1039/D3FO02688D
  47. Suares, N.C., Ford, A.C. 2011. Prevalence of, and Risk Factors for, Chronic Idiopathic Constipation in the Community : Systematic Review and Meta-analysis. The American Journal of Gastroenterology 106(9): 1582–1591. Nature Publishing Group. DOI: 10.1038/ajg.2011.164
  48. Tang, H., Zhao, T., Sheng, Y., Zheng, T. 2017. Dendrobium officinale Kimura et Migo : A Review on Its Ethnopharmacology , Dendrobium officinale Kimura et Migo : A Review on Its Ethnopharmacology , Phytochemistry , Pharmacology , and Industrialization. (January): DOI: 10.1155/2017/7436259
  49. Vogt, L., Meyer, D., Pullens, G., Faas, M., Smelt, M., Venema, K., Ramasamy, U., et al. 2015. Immunological Properties of Inulin-Type Fructans. Critical Reviews in Food Science and Nutrition 55(3): 414–436. DOI: 10.1080/10408398.2012.656772
  50. Wang, F., Ruan, X.-J., Zhang, H.-Y. 2015. BDE-99 (2,2′,4,4′,5-pentabromodiphenyl Ether) Triggers Epithelial-mesenchymal Transition in Colorectal Cancer Cells via PI3K/Akt/Snail Signaling Pathway. Tumori Journal 101(2): 238–245. DOI: 10.5301/tj.5000229
  51. Wang, J., Liang, Q., Zhao, Q., Tang, Q., Ahmed, A.F., Zhang, Y., Kang, W. 2021. The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide. Food and Chemical Toxicology 153 112305. DOI: 10.1016/j.fct.2021.112305
  52. Wang, L., Hu, L., Xu, Q., Jiang, T., Fang, S., Wang, G., Zhao, J., et al. 2017. Bifidobacteria exert species-specific effects on constipation in BALB/c mice. Food & Function 8(10): 3587–3600. DOI: 10.1039/C6FO01641C
  53. Werth, B.L., Christopher, S.-A. 2021. Laxative Use in the Community: A Literature Review. Journal of Clinical Medicine 10(1): 143. DOI: 10.3390/jcm10010143
  54. Wu, J., Chen, X., Qiao, K., Su, Y., Liu, Z. 2021. Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea. Food Science and Human Wellness 10(1): 63–71. DOI: 10.1016/j.fshw.2020.05.003
  55. Xu, J., Zhou, X., Chen, C., Deng, Q., Huang, Q., Yang, J., Yang, N., et al. 2012. Laxative effects of partially defatted flaxseed meal on normal and experimental constipated mice. BMC Complementary and Alternative Medicine 12(1): 14. DOI: 10.1186/1472-6882-12-14
  56. Xu, X., Xu, P., Ma, C., Tang, J., Zhang, X. 2013. Gut microbiota, host health, and polysaccharides. Biotechnology Advances 31(2): 318–337. DOI: 10.1016/j.biotechadv.2012.12.009
  57. Yang, H., Wu, C., Chen, L., Chang, X., Luo, G., Wu, K., Tian, W. 2023. A. macrocephala polysaccharide induces alterations to gut microbiome and serum metabolome in constipated mice. Microbial Pathogenesis 178 106084. DOI: 10.1016/j.micpath.2023.106084
  58. Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., Chen, W. 2020. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clinical Nutrition 39(10): 2960–2969. DOI: 10.1016/j.clnu.2020.01.005
  59. Zhang, G., Nie, S., Huang, X., Hu, J., Cui, S.W., Xie, M., Phillips, G.O. 2016. Study on Dendrobium officinale O -Acetyl-glucomannan (Dendronan). 7. Improving Effects on Colonic Health of Mice. Journal of Agricultural and Food Chemistry 64(12): 2485–2491. DOI: 10.1021/acs.jafc.5b03117
  60. Zhang, J., Gao, N., Jiang, H., Li, H., Cui, X., Tang, S., Jin, C., et al. 2022. Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice. Food Research International 162 112037. DOI: 10.1016/j.foodres.2022.112037
  61. Zhang, X., Tian, H., Gu, L., Nie, Y., Ding, C., Ge, X., Yang, B., et al. 2018. Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation. Science China Life Sciences 61(7): 779–786. DOI: 10.1007/s11427-017-9229-1

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