DOI: https://doi.org/10.14710/jpii.2025.26858

Studi Pengaruh Penambahan Komposisi Nano Hidroksiapatit pada Campuran Polylactide dan Poly Ɛ-Caprolactone terhadap Laju Degradasi Fiksasi Internal Pelat Tulang

*Solechan Solechan  -  Program Studi Program Profesi Insinyur, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Andri Cahyo Kumoro  -  Program Studi Program Profesi Insinyur, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Sumardi Sumardi  -  Program Studi Program Profesi Insinyur, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Agus Suprihanto  -  Program Studi Program Profesi Insinyur, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Sulardjaka Sulardjaka  -  Program Studi Program Profesi Insinyur, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Received: 30 Jul 2025; Revised: 19 Sep 2025; Accepted: 23 Sep 2025; Available online: 28 Sep 2025; Published: 2 Feb 2026.

Citation Format:
Abstract

Pemulihan patah tulang menggunakan fiksasi internal pelat yang berfungsi mempertahankan pengurangan retak selama penyembuhan tulang. Fiksasi internal pelat direkomendasikan bersifat biodegradasi secara biologis yang terbuat dari biokomposit polylactide/poly ɛ-caprolactone/nano hidroksiapatit (PLA/PCL/nHA). Material ini memiliki kekuatan mekanik tinggi, namun susah mengontrol waktu laju degradasi. Tujuan penelitian ini menciptakan fiksasi internal pelat dari biokomposit PLA/PCL/nHA dengan laju degradasi dapat diprediksi. Metode pembuatan spesimen dengan Cold Isostatic Pressing (CIP) dengan variasi penambahan persentase komposisi nHA. Tekanan kompaksi 40 MPa, temperatur sintering 150°C dan waktu penahanan 3 jam. Bertambahnya komposisi nHA mempercepat laju degradasi dan hilangnya berat spesimen. Penambahan komposisi nHA semakin besar untuk erosi permukaan semakin tinggi. Hasil ini untuk rencana implementasi spesimen pada tingkatan umur pasien. Spesimen penambahan 10wt% nHA untuk pasien di atas umur 50 tahun atau lansia. Spesimen penambahan 20wt% nHA untuk pasien dewasa, sedangkan spesimen penambahan 30wt% nHA untuk pasien bayi dan anak-anak.

 

Kata kunci: degradasi, fiksasi, pelat, nano hidroksiapatit, tulang

Fulltext View|Download

Article Metrics:

Article Info
Section: Laporan Studi Kasus
Language : ID
Recent articles
Peningkatan Kualitas Data Bidang Tanah di Kantor Pertanahan Kota Singkawang Composite Curve Pada Teknologi Pinch Rancang Bangun Peralatan Interface Hubungan Blok Otomatis Antar Stasiun Mekanik Berbasis Programmable Logic Controller (PLC) dengan Pemanfaatan Serat Optik Studi Pengaruh Penambahan Komposisi Nano Hidroksiapatit pada Campuran Polylactide dan Poly Ɛ-Caprolactone terhadap Laju Degradasi Fiksasi Internal Pelat Tulang Penerapan Lalu Lintas Sistem Satu Arah Sebagai Upaya Peningkatan Jalan Ahmad Yani Kota Tegal Magnetic Field Analysis Around SUTT 150 kV More recent articles
  1. Alisdair, R., Mac, L., Pankaj, P., Hamish, A., & Simpson, R. W. (2012). Does screw-bone interface modeling matter in finite element analyses. Journal of Biomechanics, 45, 1712–1716
  2. Akerlund, E., Escudero, A. D., Grzeszczak, A., & Persson, C. (2022). The effect of PCL addition on 3D-printable PLA/HA composite filaments for the treatment of bone defects. Polymers, 14(16), 3305. https://doi.org/10.3390/polym14163305
  3. Aizadeh, O. M., Li, Y., & Wen, C. (2019). A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications. Bioactive Materials, 4(1), 22–36. https://doi.org/10.1016/j.bioactmat.2018.11.003
  4. Allione, M., Limongi, T., Marini, M., Torre, B., Zhang, P., Moretti, M., Perozziello, G., Candeloro, P., Napione, L., Pirri, C. F., & Di Fabrizio, E. (2021). Micro/nanopatterned superhydrophobic surfaces fabrication for biomolecules and biomaterials manipulation and analysis. Micromachines, 12(12), 1501. https://doi.org/10.3390/mi12121501
  5. Arifin, A., Sulong, A. B., Muhamad, N., Syarif, J., & Ramli, M. I. (2014). Material processing of hydroxyapatite and titanium alloy (HA/Ti) composite as implant materials using powder metallurgy: A review. Materials & Design, 55, 165–175. https://doi.org/10.1016/j.matdes.2013.09.045
  6. Agus, P. (1989). Penyembuhan patah tulang (Monograph laporan penelitian). Fakultas Kedokteran Gigi, Universitas Airlangga. http://repository.unair.ac.id/id/eprint/116129
  7. Böstman, O., & Pihlajamäki, H. (2000). Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: A review. Biomaterials, 21, 2615–2621. https://doi.org/10.1016/S0142-9612(00)00129-0
  8. Burkersroda, F. V., Schedl, L., & Göpferich, A. (2002). Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials, 23(21), 4221–4231. https://doi.org/10.1016/S0142-9612(02)00170-9
  9. Chasin, M., & Langer, R. (1990). Biodegradable polymers as drug delivery systems (Vol. 45). Marcel Dekker
  10. Diba, M., Kharaziha, M., Fathi, M., Gholipourmalekabadi, M., & Samadikuchaksaraei, A. (2012). Preparation and characterization of polycaprolactone/forsterite nanocomposite porous scaffolds designed for bone tissue regeneration. Composites Science and Technology, 72, 716–723
  11. Dawoud, M. I., Taha, S. J., & Ebeid, S. J. (2016). Mechanical behaviour of ABS: An experimental study using FDM and injection moulding techniques. Journal of Manufacturing Processes, 21, 39–45
  12. Eppley, B. L., & Sadove, A. M. (1995). A comparison of resorbable and metallic fixation in healing of calvarial bone grafts. Plastic and Reconstructive Surgery, 96, 316–322
  13. Eppley, B. L., & Reilly, M. (1997). Degradation characteristics of PLLA-PGA bone fixation devices. Journal of Craniofacial Surgery, 8, 116–120
  14. Edwards, R. C., Kiely, K. D., & Eppley, B. L. (2001). The fate of resorbable poly-L-lactic/polyglycolic acid bone fixation devices in orthognathic surgery. Journal of Oral and Maxillofacial Surgery, 59, 19–25
  15. Fang, Z., & Feng, Q. (2014). Improved mechanical properties of hydroxyapatite whisker-reinforced poly(L-lactic acid) scaffold by surface modification of hydroxyapatite. Materials Science and Engineering C, 35, 190–194. https://doi.org/10.1016/j.msec.2013.11.008
  16. Firdaus, Y. (2019). Kenapa patah tulang pada anak lebih cepat sembuh daripada orang dewasa. Hello Sehat. https://hellosehat.com
  17. Gaston, M. S., & Simpson, A. H. R. W. (2007). Inhibition of fracture healing. Journal of Bone and Joint Surgery British, 89-B, 1553–1560. https://doi.org/10.1302/0301-620X.89B12.19671
  18. Gallo, A., Agnese, V., Coronnello, C., Raa, G. M., Bellavia, D., Conaldi, P. G., Pilato, M., & Pasta, S. (2018). Serum exosomal miRNA profiling and protein biomarkers for diagnosis of ascending aortic dilatation. International Journal of Cardiology, 250, 230–236
  19. Guangyao, X., Nie, Y., Ji, D., Li, J., Li, W., Zhu, Y., Luo, H., & Wan, Y. (2016). Characterization of biomedical hydroxyapatite/magnesium composites prepared by powder metallurgy assisted with microwave sintering. Current Applied Physics, 16(8), 830–836
  20. Göpferich, A. (1996). Mechanisms of polymer degradation and erosion. Biomaterials, 17(2), 103–114. https://doi.org/10.1016/0142-9612(96)85755-3
  21. Hassanajili, S., Karami-Pour, A., Oryan, A., & Talaei-Khozani, T. (2019). Preparation and characterization of PLA/PCL/HA composite scaffolds using indirect 3D printing. Materials Science & Engineering C, 104, 109960. https://doi.org/10.1016/j.msec.2019.109960
  22. ISO. (2010). ISO 10993-13: Biological evaluation of medical devices—Part 13. https://www.iso.org/standard/44050.html
  23. Kost, J., & Langer, R. (1992). Responsive polymer systems for controlled delivery of therapeutics. Trends in Biotechnology, 10, 127–131. https://doi.org/10.1016/0167-7799(92)90194-Z
  24. Lam, C. X. F., Olkowski, R., Swieszkowski, W., Tan, K. C., Gibson, I., & Hutmacher, D. W. (2008). Mechanical and in vitro evaluations of composite PLDLLA/TCP scaffolds. Virtual and Physical Prototyping, 3(4), 193–197
  25. Mofokeng, J. P., & Luyt, A. S. (2015). Morphology and thermal degradation studies of PHBV/PCL nanocomposites with TiO₂. Journal of Materials Science, 50, 3812–3824
  26. Mohseni, M., Hutmacher, D. W., & Castro, N. J. (2018). Independent evaluation of medical-grade bioresorbable filaments. Polymers, 10, 40
  27. Netti, P. A., Biondi, M., & Frigione, M. (2020). Degradation process of PLGA microspheres for sustained protein release. Polymers, 12(9), 2042
  28. Pietrzykowska, E., Romelczyk-Baishya, B., Wojnarowicz, J., Sokolova, M., Szlazak, K., Swieszkowski, W., & Lojkowski, W. (2020). Ceramic matrix composite of hydroxyapatite nanoparticles and PLA. Nanomaterials, 10(6), 1060
  29. Phillips, F. M., Bolt, P. M., He, T.-C., & Haydon, R. C. (2005). Gene therapy for spinal fusion. The Spine Journal, 5, 250S–258S
  30. Ruys, A. (2019). Processing, structure, and properties. In Alumina ceramics: Biomedical and clinical applications (pp. 71–121). Woodhead
  31. Rocha, J. H. G., Lemos, A. F., Kannan, S., Agathopoulos, S., & Ferreira, J. M. F. (2005). Hydroxyapatite scaffolds grown from cuttlefish bones. Journal of Materials Chemistry, 15(47), 5007. https://doi.org/10.1039/b510122k
  32. Rokkanen, P. U., Böstman, O., Hirvensalo, E., Mäkelä, E. A., Partio, E. K., Pätiälä, H., Vainionpää, S., Vihtonen, K., & Törmälä, P. (2000). Bioabsorbable fixation in orthopaedic surgery. Biomaterials, 21(24), 2607–2613
  33. Solechan, S., Rubijanto, J., Triyono, J., & Pujiyanto, E. (2019). Implant plate from hydroxyapatite bovine and biodegradable polymer using 3D printers. IOP Conference Series: Materials Science and Engineering, 494, 012070
  34. Solechan, S., Suprihanto, A., Widyanto, S. A., Triyono, J., Fitriyana, D. F., Siregar, J. P., & Cionita, T. (2023). Characterization of PLA/PCL/nHA biocomposites. Polymers, 15(3), 559
  35. Solechan, S., Suprihanto, A., Widyanto, S. A., Triyono, J., Fitriyana, D. F., Siregar, J. P., & Cionita, T. (2022). Effect of PCL concentrations on PLA blends. Materials, 15, 7396
  36. Sihite, J. (2021). Analisis numerik sambungan prototipe pengganti rahang patah (Skripsi). Universitas Medan Area
  37. Sadudeethanakul, S., Wattanutchariya, W., Nakkiew, W., Chaijaruwanich, A., & Pitjamit, S. (2019). Bending strength and biological properties of PLA-HA composites. IOP Conference Series: Materials Science and Engineering, 635, 012004
  38. Shuai, C., Yuan, X., Yang, W., Peng, S., He, C., Feng, P., Qi, F., & Wang, G. (2020). Cellulose nanocrystals in PLLA scaffold. Polymer Testing, 85, 106458
  39. Semba, T., Kitagawa, K., Ishiaku, U. S., Kotaki, M., & Hamada, H. (2007). Mechanical properties of PLA/PCL blends. Journal of Applied Polymer Science, 103, 1066–1074
  40. Tang, D., Tare, R. S., Yang, L. Y., Williams, D. F., Ou, K. L., & Oreffo, R. O. C. (2016). Biofabrication of bone tissue. Biomaterials, 83, 363–382
  41. Tamada, J. A., & Langer, R. (1993). Erosion kinetics of degradable polymers. Proceedings of the National Academy of Sciences, 90(2), 552–556
  42. Vacanti, C. A., Paige, K. T., Kim, W. S., Sakata, J., Upton, J., & Vacanti, J. P. (1994). Experimental tracheal replacement. Journal of Pediatric Surgery, 29(2), 201–204
  43. Wongchai, B. (2012). Screw fixation configuration effect. American Journal of Applied Sciences, 9(6), 842–845
  44. Wright, D. D. (2008). Degradable polymer composites. In Encyclopedia of Biomaterials and Biomedical Engineering (pp. 423–432). Marcel Dekker
  45. Weng, W., Han, G., Du, P., & Shen, G. (2002). Citric acid addition on sol-gel hydroxyapatite. Materials Chemistry and Physics, 74(1), 92–97
  46. Wee, C. Y., Lim, J. T., Koo, K., Lim, Q. R. T., Zhao, Y., Yang, Z., & Thian, E. S. (2022). Degradation behaviour of hydroxyapatite microsphere scaffolds. Materials Technology, 37(12), 2242–2254
  47. Wulandari, E., Wardani, F. R. A., Fatimattuzahro, N., & Dewanti, I. D. A. R. (2022). Gourami fish scale powder on porosity of glass ionomer cement. Dental Journal, 55, 33–37
  48. Wu, H.-C., Shen, F. W., Hong, X., Chang, W. V., & Winet, H. (2003). Monitoring degradation of biopolymers. Biomaterials, 24(22), 3871–3876
  49. Zhou, H., & Lee, J. (2011). Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomaterialia, 7(7), 2769–2781

Last update:

No citation recorded.

Last update:

No citation recorded.