DOI: https://doi.org/10.14710/jbtr.v6i3.8473

Radiotherapy for Recurrent Keloid: A Case Report

1Faculty of Medicine, Diponegoro University, Indonesia

2Kariadi General Hospital, Indonesia

Received: 18 Jul 2020; Revised: 22 Dec 2020; Accepted: 20 Oct 2020; Available online: 31 Dec 2020; Published: 31 Dec 2020.
Open Access Copyright (c) 2020 Journal of Biomedicine and Translational Research

Citation Format:
Abstract

Background: Keloid is a benign growth of connective tissue. There are several risk factors that play a role in keloid growth. Excision surgery is one of the modalities in the treatment of keloids. However, excision surgery alone has a recurrence rate of 45-100%.

Case: Male, 37 years old, with complaints arising from a keloid lesions in the left earlobe since three years ago with a history of previous injuries. The lesions is then operated on but always grows back postoperatively. The number of surgeries that have been carried out three times with further treatment in the form of corticosteroid injection. However, keloid still recurrence. Finally it was decided to undergo treatment with surgery followed by radiotherapy within a period of no more than 24 hours postoperatively. Follow-up after six months gave good results without recurrence.

Discussion: Keloid has a high recurrence rate after excision surgery. Surgery followed by radiotherapy has a low recurrence rate compared to surgery or surgery followed by administration of corticosteroid injections. Radiotherapy as adjuvant therapy for postoperative keloid excision has the role of sterilizing the connective tissue stem cell active fibroblasts and acute inflammatory cells that grow in the early postoperative period. A study states that administration of postoperative radiation with electrons in keloids in the earlobe at a dose of 15 Gy in three fractions gives a low recurrence rate and a low risk of side effects in the surrounding soft tissue.

 

Fulltext View|Download
Keywords: keloids; recurrence; radiotherapy.

Article Metrics:

Article Info
Section: Case Reports
Language : EN
Recent articles
The Effect of Glutathione on Serum Malondialdehyde (MDA) Level in Retinopathy of Prematurity Rat Models Peanut (Arachis hypogaea) Shells Extract and Apis dorsata Honey Reduce Matrix Metalloproteinase-3 in Monosodium Iodoacetate-Induced Osteoarthritic Rats Comparison of Very Low Birth Weight Preterm Infants with And Without Experienced Target Weight Gain on The Administration of Human Milk Fortifier Radiotherapy for Recurrent Keloid: A Case Report Neuromyelitis Optica (NMO) in Children: A Rare Case Report SRY-negative in 46, XX Male Testicular DSD: a case report Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology Hyperuricemia as a Risk Factor for Cardiovascular Diseases More recent articles
  1. Flickinger J C. A Radiobiological Analysis of Multicenter Data for Postoperative Keloid Radiotherapy. Radiat Oncol Biol [Internet]. Elsevier Ltd; 2011;79(4):1164–70. Available from: http://dx.doi.org/10.1016/j.ijrobp.2009.12.019
  2. Jones K, Fuller CD, Luh JY, Childs CC, Miller AR, Tolcher AW, et al. BMC Dermatology Case report and summary of literature : giant perineal keloids treated with post-excisional radiotherapy. BMC Dermatology7. 2006;6:1–6
  3. Shaheen A. Risk Factors of Keloids : A Mini Review Risk Factors of Keloids : A Mini Review. Austin J Dermatology. 2017;4(2):1–5
  4. Shaheen A, Khaddam J, Kesh F. Risk factors of keloids in Syrians. BMC Dermatol [Internet]. BMC Dermatology; 2016;16(13):1–11. Available from: http://dx.doi.org/10.1186/s12895-016-0050-5
  5. Lei-ming Sun, Kuo-hsien Wang YGL. Keloid incidence in Asian people and its comorbidity with other fibrosis-related diseases : a nationwide population-based study. Arch Dermatol Res. 2014;306:803–8
  6. Mustoe, Thomas A; Cooter Retney D; Gold, Michael H; Hoobs F. D. Richards; Ramelet, Albert-Andrien; Shakespeare PG. et al. Keloid International Clinical Recomendation.pdf. Plast Reconstuctive Surg. 2002;110:560–71
  7. Dinh Q, Veness M, Richards S. Role of adjuvant radiotherapy in recurrent earlobe keloids. Aust J Dermatol. 2004;45:162–6
  8. Ogawa R, Mitsuhashi K, Hyakusoku H MT. Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast Reconstuctive Surg. 2003;111(2):547–53
  9. Shen J, Lian X, Sun Y, Wang X, Hu K, Hou X, et al. Hypofractionated electron-beam radiation therapy for keloids : retrospective study of 568 cases with 834 lesions. J Radiat Res. 2015;56(5):811–7
  10. Mankowski P, Kanevsky J, Tomlinson J, Dyachenko A, Luc M. Optimizing Radiotherapy for Keloids. Ann Plascic Surg. 2017;78(4):403–11
  11. Kim K, Son D, Kim J. Radiation Therapy Following Total Keloidectomy: A Retrospective Study over 11 Years. Arch Plast Surg. 2015;24(5):588–95

Last update:

No citation recorded.

Last update:

No citation recorded.