Optimization of Xanthone Extraction From Mangosteen Peel Using Natural Deep Eutentic Solvent and Microwave Assisted Extraction for Anti-Aging

Fitroh Bawa Berkah; Vita Paramita

doi:10.14710/jvsar.v0i0.26555

DOI: https://doi.org/10.14710/jvsar.v0i0.26555

Optimization of Xanthone Extraction From Mangosteen Peel Using Natural Deep Eutentic Solvent and Microwave Assisted Extraction for Anti-Aging

Fitroh Bawa Berkah , Vita Paramita

Department of Industrial Technology, Vocational School, Diponegoro University, Jalan Gubernur Mochtar, 50275 Semarang, Indonesia, Indonesia

Received: 10 Apr 2025; Revised: 11 Jun 2025; Accepted: 12 Jun 2025; Available online: 18 Jun 2025; Published: 30 Jun 2025.

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Abstract

The peel of mangosteen (Garcinia mangostana L.) contains bioactive compounds such as xanthones, phenolics, flavonoids, anthocyanins, and vitamin C, which exhibit anti-inflammatory, antioxidant, and anti-aging properties. Microwave Assisted Extraction (MAE) has been found to be more efficient than conventional extraction methods. This study aims to optimize multiple response variables in MAE by varying power levels (300, 375, and 450 watt) and extraction times (2, 4, and 6 minute) using a Natural Deep Eutectic Solvent (NADES) composed of lactic acid, sodium acetate, and distilled water in a 3:1:2 ratio. The optimization was performed using Response Surface Methodology (RSM), while the bioactive compound content was quantified using UV-Vis spectrophotometry. The optimal extraction xanthone were determined at 300 watt and 4.46 minute resulting in 1.40%.

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Keywords: Mangosteen Peel; Xanthone, Extraction; Optimization; Response Surface Methodology

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Language : EN

In 2025: Just Accepted Manuscript and Article In Press 2025

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