DOI: https://doi.org/10.14710/jbtr.v4i2.3520

The Effects of Zinc Supplementation on Immune Response of Obese Children With Family History of Atopy

Faculty of Medicine, Diponegoro University, Indonesia

Received: 2 Nov 2018; Published: 31 Dec 2018.
Open Access Copyright (c) 2018 Journal of Biomedicine and Translational Research

Citation Format:
Abstract
Introduction: Obesity is associated with low-grade chronic inflammation and disbalance between cytokine production of T helper1 and T helper2 cells.  Zinc plays role in balancing immune response, has anti-oxidant and anti-inflammation activities; its deficiency also common in obesity.  The role of zinc supplementation in children with obesity with risk of atopy needs to be elucidated.
Materials and Method: We performed randomized controlled trial double-blind to investigate the effect of daily 15 mg zinc supplementation for 6 weeks in children aged 13 to 14 years old with obese who has family history of atopy.  Subjects were divided into group of zinc supplementation and placebo, recruited from junior high schools from Semarang municipality, performed during periods from January to December 2013.  Plasma zinc concentration, leptin, immunoglobulin-E (Ig-E), interferon-γ (IFN-γ), interleukin-4 (IL-4) were measured, also body weight, height and ISAAC questionnaire to recruit subjects with family history of atopy.
Result: There were 36 subjects.  The concentration of zinc serum, Ig-E, IFN-γ, and IL-4 of two groups before supplementation were not significantly different (p>0.05).  Zinc supplementation increase the mean level of zinc concentration on treatment group compare to placebo group (27.74+11.80 vs 3.47+2.55, p=0.000).  The concentration of Ig-E, IFN-γ and IL-4 serum were decreased at treatment group (15.5+20.46 vs 20.02+38.02, p=0.613), (1.82+3.59 vs 0.911+3.51, p=0.174), and (4.76+6.49 vs 2.44+4.41, p=0.085) respectively.  
Conclusion: Zinc supplementation increased the level of zinc serum concentration of obese children and decreased the risk of atopy.


Note: This article has supplementary file(s).

Fulltext View|Download |  Cover letter
Cover letter for submission of manuscript to Journal of Biomedicine and Translational Research
Subject Cover letter
Type Cover letter
  Download (12KB)    Indexing metadata
Keywords: obese children; atopy; zinc supplementation
Funding: University of Diponegoro Semarang; The Head of National Institute of Health Research and Development; Project Budgeting Secretary of National Institute of Health Research and Development

Article Metrics:

Article Info
Section: Original Research Articles
Language : EN
Recent articles
Factors Affecting Parents' Acceptance towards Children with Familial Intellectual Disability (ID) The Effects of Zinc Supplementation on Immune Response of Obese Children With Family History of Atopy Malaria, hepatitis B and HIV /AIDS, and their co-infection among Patients Visiting Health Centres in Akure, Nigeria A rare case of trisomy 18 with split-hand/split-foot malformation (SHFM) Marfan Syndrome, A Review More recent articles
  1. Kral JG. (2001). Morbidity of severe obesity. Surg Clin North Am 8:1039-61
  2. Apandi PR, Setiabudiawan B, Sukadi A. (2001). Correlation between obesity with atopy and family history of atopy in children. Paediatrica Indonesiana 51:227-33
  3. Leung TF, Kong AP, Chan IH, Choi KC, Ho CS, Chan MH, et al. (2009). Association between obesity and atopy in Chinese schoolchildren. Int Arch Allergy Immunol 149(2):133-40
  4. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz AM, et al. (2009). Association of Obesity with IgE and Allergy Sumptoms in Children and Adolescents: Results from NHANES 2005-2006. J Allergy Clin Immunol 123(5):1163-9
  5. WHO Obesity and overweight. Cited from: http://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight 2018
  6. Pacifico L, Di Renzo L, Anania C, Osborn JF, Ippoliti F, Schiavo E, et al. (2006). Increased T-helper interferon-γ-secreting cells in obese children. European Journal of Endocrinology 154:691-7
  7. Tateya S, Kim F, Tamori Y.(2013). Recent advances in obesity-induced inflammation and insulin resistance. Front Endocrinol (Lausanne) 4:1-14. doi: 10.3389/fendo.2013.00093
  8. Lappas M, Permezel M, Rice GE. (2005). Leptin and adiponectin stimulates the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-ĸβ, peroxisomal proliferator-activated receptor-γ and extracellularly regulated kinase ½. Endocrinology 146:3334-42. doi: 10.1210/en.2005-0406
  9. Farooqi IS, Matarese G, Lord G, Keogh JM, Lawrence E, Agwu C, et al. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation 110:1093-103
  10. Matarese G, Moschos S, Mantzoros CS. (2005). Leptin in immunology. J Immunol 174:3137-42
  11. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klismis-Zacas D, Mantzoros CS. (2001). The Q223R pollymorphism of the leptine receptor gene is significantly associated wih obesity and predicts a small percentage of body weight and body composition variability. Clin Endoc Metab 86:4434-9
  12. Brunzell JD, Chait A. (2003). Lipoprotein Metabolism: Structure and Function. Els. http://www.els.net/WileyCDA/Elsarticle/refld-a0000609
  13. Kay AB. (2001). Allergy and allergic diseases. N Engl J Med 334:30-7
  14. Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. (2017). Zinc and Oxidative Stress: Current Mechanisms. Antioxidants 6(2):E24
  15. Marreiro DDN, Fisberg M, Cozzolino SMF. (2004). Zinc Nutritional Status and Its Relationships with Hyperinsulinemia in Obese Children and Adolescents. Biological Trace Elements 10:137-49
  16. Martin SS, Qasim A, Reilly MP. Leptin Resistance. A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease. J Am Coll Cardiol. 2008;52(15):1201-1210
  17. Jr MGM, Leibel RL, Seeley RJ, Schwartz MW. Obesity and Leptin Resistance: Distinguishing Cause from Effect. Trends Endocrinol Metab. 2011;21(11):643-651
  18. Viera VJ, Ronan AM, Windt MR, Tagliaferro AR. (2005). Elevated atopy in healthy obesity women. Am J Clin Nutr 82:504-9
  19. Arteaga-Solis E, Zee T, Emala CW, Vinson C, Wess J, Karsenty G. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013;17(1):35-48
  20. Khan AR, Awan FR. Leptin resistance: A possible interface between obesity and pulmonary-related disorders. Int J Endocrinol Metab. 2016;14(1)
  21. Youssef DM, Elbehidy RM, Shokry DM, Elbehidy EM. The influence of leptin on Th1/Th2 balance in obese children with asthma. J Bras Pneumol. 2013;39(5):562-568
  22. Tascilar ME, Ozgen IT, Abaci A, Serdar M, Oykut O. (2011). Trace element in obesity Turkish children. Biol Trace Elem Res 143:188-95
  23. Marreiro D, Fisberg M, Cozzolino S. (2002). Zinc Nutritional Status in Obese Children and Adolescent. Biological Trace Element Research 107-22
  24. Chen MD, Song YM, Lin PY. (2000). Zinc may be a mediator of leptin production in humans. Life Science 66:2143-9
  25. Murphy K, Travers P, Walport M, editors. (2008). Janeway’s Immunobiology 7th ed. New York: Garland Science 2008

Last update:

No citation recorded.

Last update:

No citation recorded.