DOI: https://doi.org/10.14710/jbtr.v9i2.16885

Mechanism of Immune System Dysfunction, Apoptosis and Oxidative Stress on Endometriosis

1Faculty of Medicine, Universitas Indonesia, Indonesia

2Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Indonesia

Received: 26 Dec 2022; Revised: 20 Jul 2023; Accepted: 4 Aug 2023; Available online: 31 Aug 2023; Published: 31 Aug 2023.
Open Access Copyright (c) 2023 Journal of Biomedicine and Translational Research
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Endometriosis is gynecology disease that still needs advance knowledge to develop best treatment for enhancing  the best quality of patient life. It is characterized by forming the endometrium tissue outside the uterus and happened approximately in 5-10% of reproductive women. Endometriosis with poor prognosis can be a high risk of endometrium cancer, ovarian cancer and results in infertility. A deep attempt to reach the knowledge of clear molecular etiology of endometriosis is needed. Here, there are three molecular mechanism dysfunction that occurs on endometriosis; (1) immune system dysfunction, (2) disturbance in apoptosis signal, (3) and oxidative stress elevation. Therefore, the determination of molecular pathogenesis of endometriosis will be useful in developing of diagnostic and therapeutic methods.

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Keywords: Endometriosis; Immune Dysfunction; Apoptosis; Oxidative Stress

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Section: Review Articles
Language : EN
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