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Correlation between Interleukin-17 Levels with C-Reactive Protein and Neutrophil Lymphocyte Ratio in Sepsis

1Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Indonesia

2Department of Internal Medicine, Faculty of Medicine, Universitas Diponegoro, Indonesia

3Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Diponegoro, Indonesia

4 Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia

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Received: 26 Jul 2022; Revised: 23 Aug 2022; Accepted: 25 Aug 2022; Available online: 31 Aug 2022; Published: 31 Aug 2022.
Open Access Copyright (c) 2022 Journal of Biomedicine and Translational Research
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Background: Sepsis is a condition in systemic infection associated with organ
dysfunction. Interleukin-17 is a pro-inflammatory cytokine produced by Th-17 cells. C-
reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used as
markers of inflammation. The relationship between IL-17 as a proinflammatory
cytokine with CRP and NLR has not been reported.
Objective: This study aims to prove the correlation between IL-17 with CRP and NLR
in septic patients.
Methods: Analytical observational study with a cross-sectional approach was carried
out on 40 septic patients in July–December 2020. IL-17 levels were obtained by the
ELISA method while CRP levels were obtained using the immunoturbidimetric method.
NLR was the result of dividing the absolute number of neutrophils and lymphocytes
from the automatic hematology analyzer. Correlation between variables was performed
using Spearman correlation test.
Results: The median levels of IL-17, CPR, and NLR were 363.55 (11.4-1695.80)
pg/mL, 13.25 (0.43-53.87) mg/L, and 12.00 (2.26–48.5), respectively. The Spearman
correlation test between IL-17 levels and CRP obtained p = 0.019, r = 0.37, and NLR p
= 0.425, r = 0.13.
Conclusion: There is a weak positive correlation between IL-17 levels and CRP in
septic patients. There is no correlation between IL-17 levels and NLR in septic patients.

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Keywords: Interleukin-17, CRP, NLR, sepsis

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