DOI: https://doi.org/10.14710/jbtr.v8i2.15318

Comparison of Testosterone Undecanoate (TU) and Testosterone Enanthate (TE) with Combination of Depot Medroxyprogesterone Acetate (DMPA) on Spermatogenic Cells in Men

Faculty of Medicine, Universitas Indonesia, Indonesia

Received: 25 Jul 2022; Revised: 12 Aug 2022; Accepted: 22 Aug 2022; Available online: 31 Aug 2022; Published: 31 Aug 2022.
Open Access Copyright (c) 2022 Journal of Biomedicine and Translational Research
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Abstract

Introduction: Male hormonal contraception known as safe, effective, and reversible
contraception. World Health Organization (WHO) multicentre study has been conducted a
clinical study administrating of testosterone regimens and progestin to male with a remarkable
result. Azoospermia or severe oligozoospermia occurred in men with injection of Testosterone
Enanthate (TE) and Depot Medroxyprogesterone Acetate (DMPA) as well as Testosterone
Undecanoate (TU) and DMPA for a longer period. Decreasing gonadotropin as well as
testosterone could lead to the amount of spermatogenic cells population declining by suppressing
the development of many kinds of cells. This narrative review was to compare how
spermatogenic suppression in TE and TU with Combination of DMPA. Method: We are
randomly select article or journal from several databases and individual journal in certain
keywords. The keyword used were : (male hormonal contraception) OR (regimen testosterone))
AND (progestin) OR (DMPA) OR (Testosterone enanthate) OR (Testosterone undecanoate) OR
(male hormonal contraception combination)) AND (DMPA to spermatogenic cells) OR
(Testosterone and DMPA to germ cell development)). After initial searching from databases and
individual journal website, 16 scientific articles or journals selected for the review. Result: The
result indicated that injection of TE and DMPA had suppressed spermatogenesis, might not
suppressed sperm production for a longer period but the decreasing in type B spermatogonia
until pachytene spermatocyte did occur. On the other hand, injection of TU and DMPA could
maintain the suppression of sperm production for a longer period due to sustainable higher serum
MPA with combination to even longer-acting TU would have more profound effect for that.
Conclusion: It was known that combination of TU and DMPA might have better suppression on
sperm production than TE and DMPA, otherwise further research needs to be obtained from the
combination of TU and DMPA on spermatogenic development and the association with
intratesticular testosterone.

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Keywords: Male hormonal contraception, Gonadotropin, Testosterone, Testosterone Enanthate and DMPA, Testosterone Undecanoate and DMPA, Spermatogenic suppression.
Funding: Universitas Indonesia

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Section: Review Articles
Language : EN
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  16. Kelsey TW, Amy M, Rod TM et al. A Normative Model of Serum Inhibin B in Young Males. PLoS ONE. 2016;11(4):e0153843. DOI : 10.1371/journal.pone.0153843
  17. O’Donnell L, Robert IM. Testosterone: Action, Deficiency, Substitution. UK: Cambrigde University Press. 2012
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  21. Yuen F, Brian TN, Ronald SS et al. Continuing the search for hormonal male contraceptive. Best Prac & Res Clin Obs and Gyn. 2020; 66:83-94. DOI : 10.1016/j.bpobgyn.2020.02.003
  22. Chao J, Stephanie TP, Richard AA. Male Contraception. Best Prac & Res Clin Obs and Gyn. 2014:1-13. DOI : http://dx.doi.org/10.1016/j.bpobgyn.2014.05.008
  23. Long JE, Min SL, Diana LB. Update on Novel Hormonal and Nonhormonal Male Contraceptive Development. The J of Clin Endocrinol & Metab. 2021;106(6):e2381-e92. DOI :10.1210/clinem/dgab034
  24. Silvia WL, Seruni TK, Yurnadi HM, Andon H, Tjahjo DT, Reny I. An Update Of Male Contraception : A Review Of Cellular Perspective. J Of Glo Pharma Tech. 2019;11(1):219-29
  25. Gu YQ, Ding-Zhi M, Xing-Hai W et al. Male Hormonal Contraception: Effects Of Injections Of Testosterone Undecanoate And Depot Medroxyprogesterone Acetate At Eight-Week Intervals In Chinese Men. J Clin Endocrinol Metab. 2004;89(5):2254-62. DOI: 10.1210/jc.2003-031307

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