DOI: https://doi.org/10.14710/jbtr.v3i1.1206

Comparison of Prostaglandin Analogue and Selective Laser Trabeculoplasty Capability to Maintain Intraocular Pressure Fluctuation on Primary Open Angle Glaucoma

Faculty of Medicine Diponegoro University, Indonesia

Received: 11 May 2017; Published: 23 Jun 2017.
Open Access Copyright (c) 2017 Journal of Biomedicine and Translational Research

Citation Format:
Abstract

Background: Glaucoma patients often come with intraocular pressure (IOP) that reach target pressure, but still have glaucoma progression due to IOP fluctuation. Water drinking test (WDT) can be used as a method to predict IOP fluctuation.

Purpose: To compare prostaglandin analogue (PGA) and selective laser trabeculoplasty (SLT) capability to maintain IOP fluctuation on primary open angle glaucoma (POAG).

Method: This clinical experimental research was conducted at Dr. Kariadi Hospital. Subjects were POAG patients selected with consecutive sampling. Intraocular pressure was measured before and after WDT. After WDT, IOP was measured every 15 minutes until 1 hour. Peak IOP and IOP fluctuation data were collected then analyzed with t-test.

Results: Forty two eyes from 30 POAG patients were analyzed. Twenty six eyes in PGA group and 16 eyes in SLT group. Most of the subjects were male with mild glaucoma degree. WDT increased IOP significantly on both groups. Mean IOP pre WDT was 14.58 ± 2.580 mmHg and 16.94 ± 2.645 mmHg in PGA and SLT groups. Mean peak IOP post WDT was 22.73 ± 4.114 mmHg and 25.75 ± 5.859 mmHg in PGA and SLT groups. Mean IOP fluctuation was 8.15 ± 4.202 mmHg and 8.81 ± 5.344 mmHg in PGA and SLT groups. Peak IOP and IOP fluctuation result analysis on both groups were not significantly different.

Conclusion: Prostaglandin analogue and SLT had equal capability to maintain IOP fluctuation but still higher than normal fluctuation (>6 mmHg) that affects glaucoma progression.

Note: This article has supplementary file(s).

Fulltext View|Download |  Research Results
Comparison of Prostaglandin Analogue and Selective Laser Trabeculoplasty Capabilityto Maintain Intraocular Pressure Fluctuation on Primary Open Angle Glaucoma
Subject Primary open angle glaucoma; prostaglandin analogue; selective laser trabeculoplasty; water drinking test
Type Research Results
  Download (63KB)    Indexing metadata
Keywords: Primary open angle glaucoma; prostaglandin analogue; selective laser trabeculoplasty; water drinking test

Article Metrics:

Article Info
Section: Original Research Articles
Language : EN
Recent articles
Multidisciplinary Management of Disorders of Sex Development in Indonesia, A Prototype in Developing Country Comparison of Prostaglandin Analogue and Selective Laser Trabeculoplasty Capability to Maintain Intraocular Pressure Fluctuation on Primary Open Angle Glaucoma Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells CHARGE Syndrome: An Indonesian Case Report More recent articles
  1. Cioffi GA, Durcan FJ, Girkin CA, Gupta N, Piltz-Seymour JR, Samuelson TW, et al. Basic and clinical science course: Glaucoma section 10. San Fransisco: American Academy of Ophthalmology; 2014. p 73-78, 166, 180
  2. Gangguan penglihatan masih menjadi masalah kesehatan. Kementrian Kesehatan Republik Indonesia [serial online]. 2010 [cited 2015 Sep 27]. Available from: http://www.depkes.go.id/pdf.php?id=845
  3. Bhartiya S, Ichhpujani P. The need to maintain intraocular pressure over 24 hours. Jaypee Journal [serial online]. 2012 Sep [cited 2015 Sep 28] 6 (3): 120-123. Available from: http://www.jaypeejournals.com/eJournals/ShowText.aspx?ID=3222&Type=FREE&TYP=TOP&IN=_eJournals/images/JPLOGO.gif&IID=247&isPDF=YES
  4. Kumar RS, de Guzman MH, Ong PY, Goldberg I. Does peak intraocular pressure measured by water drinking test reflect peak circadian levels? A pilot study. Pubmed [serial online]. 2008 May [cited 2015 Sep 28]. Available from:
  5. http://www.ncbi.nlm.nih.gov/pubmed/18700916
  6. Bressler NM, Ahmed IIK, Nguyen QD, Shah M, Do DV, dan Hwang T. The stratus OCT primer: Essential OCT. Baltimore : Wilmer Eye Institute; 2006. p 37-49
  7. Detry-Morel M. General review: currents on target intraocular pressure and intraocular pressure fluctuations in glaucoma management. Bull. Soc. belgeOphtalmol [serial online]. 2008 May [cited 2017 Mar 10]; 308: 38. Available from : www.ophthalmologia.be/download.php?dof_id=54
  8. Rudnicka AR, Isa SM, Owern CG, Cook DG, Ashby D. Variations in primary open-angle glaucoma prevalence by age, gender, and race: A bayesian meta-analysis. Investigative Ophthalmology & Visual Science. [serial online]. 2006 Oct [cited 2017 Mar 13]; 47: 4254-4261. Available from:
  9. http://iovs.arvojournals.org/article.aspx?articleid=2124829
  10. Nagar M, Ogunyomade A, O’Brart DP, Howes F, Marshall J. A randomized, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma. Br J Ophthalmol. [serial online]. 2005 Nov [cited 2017 Mar 18]; 89(11): 1413-7. Available from:
  11. https://www.ncbi.nlm.nih.gov/pubmed/16234442
  12. Katz LJ, Steinmann WC, Kabir A, Molineaux J, Wizov SS, Marcellino G, et al. Selective laser trabeculoplasty versus medical therapy as initial treatment of glaucoma: a prospective, randomized trial. PubMed. [serial online]. 2012 Sep. [cited 2015 Nov 29]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21543992
  13. Nagar M, Luhishi E, Shah N. Intraocular pressure control and fluctuation: the effect of treatment with selective laser trabeculoplasty. Pubmed [serial online]. 2009 [cited 2015 Sep 29]. Available from:
  14. http://www.ncbi.nlm.nih.gov/pubmed/19106150
  15. Kiddee W, Atthavuttisilp S. The effects of selective laser trabeculoplasty and travoprost on circadian intraocular pressure and fluctuations. Medicine. [serial online]. 2017 Jan [cited 2017 Mar 18] 96:6 (e6047). Available from:
  16. http://journals.lww.com/mdjournal/Fulltext/2017/02100/The_effects_of_selective_laser_trabeculoplasty_and.31.aspx

Last update:

No citation recorded.

Last update:

No citation recorded.