Kajian Sistematik: Aktivitas Kuersetin sebagai Inhibitor Kanker Payudara secara In Vitro

Nadhira Dzaky Naushafira; Hanuna Hanuna; Monika Kumala Dewi; Wong Vivian Nathania Selius

doi:10.14710/genres.v2i2.15774

DOI: https://doi.org/10.14710/genres.v2i2.15774

Kajian Sistematik: Aktivitas Kuersetin sebagai Inhibitor Kanker Payudara secara In Vitro

*Nadhira Dzaky Naushafira - Department of Pharmacy, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Hanuna Hanuna - Department of Pharmacy, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Monika Kumala Dewi - Department of Pharmacy, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Wong Vivian Nathania Selius - Department of Pharmacy, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Received: 5 Sep 2022; Revised: 11 Sep 2022; Accepted: 17 Sep 2022; Available online: 26 Sep 2022; Published: 3 Oct 2022.

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Abstract

Kuersetin merupakan senyawa flavonoid yang melimpah di alam. Kuersetin memiliki aktivitas anti kanker sehingga dapat digunakan sebagai alternatif terapi kanker termasuk kanker payudara. Perlu dilakukan studi lebih lanjut mengenai potensinya dalam menghambat sel kanker payudara. Tujuan dari kajian sistematik ini adalah untuk mengetahui aktivitas kuersetin sebagai inhibitor kanker payudara secara in vitro. Pencarian dilakukan dari dua database yaitu PubMed dan Springer. Literatur yang digunakan adalah literatur yang diterbitkan pada lima tahun terakhir dan memenuhi kriteria inklusi yang ditetapkan. Terdapat 10 jurnal yang relevan terhadap tujuan kajian sistematik ini. Sebanyak tujuh penelitian menggunakan jenis sel kanker payudara MCF-7 dan tiga penelitian menggunakan jenis sel kanker payudara MDA-MB. Penelitian tersebut menunjukkan hasil IC50yang beragam dari uji DPPH dan MTT, tetapi aktivitas antioksidan ataupun sitotoksik dari penelitian-penelitian tersebut termasuk kuat. Kuersetin memiliki aktivitas induksi kematian sel kanker payudara dengan tingkat selektivitas yang tinggi. Perbedaan preparasi kuersetin dapat mempengaruhi efek anti kanker payudara terhadap sel MCF-7 dan MDA-MB.

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Keywords: MCF-7, MDA-MB, DPPH, MTT, sitotoksik

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In Vol 2, No 2 (2022): Generics: Journal of Research in Pharmacy, Volume 2, Edisi 2, 2022

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