Expression of TTF-1 and CK-7 in the Diagnosis of Pleural Effusion Cytology Suspected Lung Adencarcinoma

*Patricia Diana Prasetiyo  -  Faculty of Medicine Diponegoro University, Indonesia
Ika Pawitra  -  Faculty of Medicine Diponegoro University, Indonesia
Indra Wijaya  -  Faculty of Medicine Diponegoro University, Indonesia
Received: 4 Mar 2015; Published: 1 Sep 2015.
Open Access
Citation Format:
Article Info
Section: Original Research Articles
Language: EN
Full Text:
In Vol 1, No 1 (2015): April 2015
Statistics: 541 264

Abstract

Background : Lung cancer is the mayor disease that cause death worldwide including Indonesia especially Nonsmall cell lung cancer (NSCLC) consisting of adenocarcinoma, squamus carcinoma (SqCCA) and large cell carcinoma. Incidency of lung adenocarcinoma continues to rise recently about 40% of all NSCLC.


Methods : Descriptive observational study design. The study population included the patients who were hospitalized at Kariadi central hospital in Semarang and had thorax X-ray or CT scan of thorax with a diagnosis of suspected lung malignancy, at the period of January 2012 – 2013. The variables assessed are expression of TTF-1 and CK-7.


Result : A total of 20 samples subjected to Pearson correlation test with result of p value = < 0,001 and r = 0,867. Presentation of the highest expression TTF-1 in the all study sample is Adenocarcinoma 73,3% and highest expression CK-7 is also Adenocarcinoma 68,6%.


Conclusion : Immunocytochemistry of TTF-1 and CK-7 can be used to determine Adenocarcinoma malignancy on cytological sample of suspected malignant pleural effusion

Keywords
TT-1; CK-7; Adenocarcinoma; pleural effusion; Nonsmall cell lung cancer

Article Metrics:

  1. Apdani R, Karakteristik Penderita Kanker Paru Yang Dirawat Inap Di Bangsal Paru Rumah Sakit Umum Dr. Soedarso Pontianak Periode 1 Januari 2006 - 31 Desember 2010. Skripsi . Pontianak: Program Studi Pendidikan Dokter Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Tanjungpura, 2011.
  2. Diederich S. Focus On: Lung Cancer.InCT screening for lung cancer . Cancer Imaging.; 8:24-26. 2008
  3. Fatima N, Cohen C, Lawson D.M.T, Siddiqui M.T. TTF-1 and Napsin A Double Stain. Cancer Cytopathology; 25:127-32.2011
  4. Flieder D.B. Screen-Detected Adenocarcinoma of the Lung. In Practical Points for Surgical Pathologists Am J Clin Pathol;119(1):39-57, 2003
  5. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M,Boyle P. Estimates of the cancer incident and mortality in Europe in 2006.Ann Oncol;18:581-92. 2007
  6. Hecht J. L, Pinkus,J.L, Weinstein L.J, Pinkus G.S. The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin. Am J Clin Pathol;116:483-488,2001
  7. John C, Ruckdeschel, Myths &Facts about lung cancer: What you need to know. USA.Bryson Biomedical. 2006
  8. Kingshuk Roy Choudhury, Kevin J. Yagle, Paul E.
  9. Swanson, Kenneth A. Krohn,Joseph G. Rajendran. A Robust Automated Measure of Average Antibody Staining in Immunohistochemistry Images. Journal of Histochemistry & Cytochemistry. Volume 58(2): 95 , 2010
  10. Kanker Paru. dalam Pedoman Diagnosis & Penatalaksanaan Di Indonesia: Perhimpunan Dokter Paru Indonesia. 2013
  11. Kadara H, Behrens C, Yuan P, Solis L, Liu D, Xuemin Gu, et al. A five-gene and corresponding- protein signature for stage-Ilung adenocarcinoma prognosis. Clin Cancer Res.2010.
  12. Lam B, Lam W.K, Lam C.L, Ooi G.C, Ho JCM, Wong M.P.et,al. Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature. Postgrad Med J 2001;77:708-12
  13. Lung Cancer , Lung Adenocarcinoma, College of American Pathologists, Dec.. Available www.cancer.gov, 2006
  14. Lin C.C, Chen L.C, Tseng V.S, Yan J.J, Lai W.W, Su W.P. Malignant pleural effusion cells show aberrant glucose metabolism gene expression Division of Hematology/ Oncology Department of Internal Medicine Hospital and College of medicine, National Cheng Kung University College. Taiwan. 2010
  15. Mignotte H.N, Guillem P, Vesin A, Toffart A.C, Colonna M, Bonneterre V, et al. Primary lung adenocarcinoma: characteristics by smoking habit and sex. Eur Respir J.; 38: 1412-1419, 2011.
  16. Persatuan Ahli Penyakit Dalam. Buku Ajar Ilmu Penyakit Dalam jilid2. Jakarta : Balai Penerbit FK UI; VII:915-18,1996
  17. Parkin M Tyczynski J.E, Boffetta P Samet J, Shields P, Caporaso N, Lung cancer epidemiology and etiology. In . Travis W.D, Brambilla E, Hermelink H.K.M, Harris C.c,Editors. Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours. 2004.
  18. Pao W, Vincent A, Miller, Katerina A. Politi, Gregory J, et al.Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain. PLoS Medicine.;2(3):225-33. 2005
  19. Remmelink M. New Lung Adenocarcinoma Classification In Daily Practice. 2012.
  20. Syahruddin E, Pratama AD, Arief N. A retrospective study : clinical and diagnostic characteristics in advanced stage of lung cancer patients with pleural effussion in persahabatan hospital 2004 – 2007. J Respir Indo;30:146-151,2010
  21. William D. Travis, Brambilla E; Noguchi M, Andrew G, Nicholson. Diagnosis of Lung Cancer in Small Biopsies and Cytology. In Implications of the 2011 International Association for the Study of Lung Cancer/ American Thoracic Society/ European Respiratory Society Classification. Arch Pathol Lab Med.;137:668-684, 2013

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Journal of Biomedicine and Translational Research Diponegoro University as publisher of the journal.

Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc., will be allowed only with a written permission from Journal of Biomedicine and Translational Research Diponegoro University.

Journal of Biomedicine and Translational Research Diponegoro University, the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Journal of Biomedicine and Translational Research Diponegoro University (JBTR) are sole and exclusive responsibility of their respective authors and advertisers.

The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form JBTR] 

The copyright form should be signed originally and send to the Editorial Office in the form of original mail, scanned document or fax :  
Journal of Biomedicine and Translational Research Faculty of Medicine, Diponegoro University
Jl. Prof. Soedarto, Kampus UNDIP Tembalang, Semarang, Central Java, Indonesia 50275, Telp.: +62-24-8412311, Fax.: +62-24-8454714
Email: jbtr@fk.undip.ac.id and jbtr@live.undip.ac.id