Anti-Inflammatory Potential of Takokak (Solanum Torvum) Ethanol Extract in Rats Exposed to 7,12-Dimethylbenz[A]Anthracene (Dmba)

*Nur Rahman -  Bogor Agricultural University, Indonesia
Sri Anna Marliyati -  Bogor Agricultural University, Indonesia
Muhammad Rizal Martua Damanik -  Bogor Agricultural University, Indonesia
Faisal Anwar -  Bogor Agricultural University, Indonesia
Received: 2 Mar 2015; Published: 28 Aug 2015.
Open Access
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Section: Original Research Articles
Language: EN
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Abstract
Background: Takokak fruit (Solanum torvum) is a type of eggplant containing solasodin, solamargin, solasonin and other phytochemicals components with anti-inflammatory and anti-cancer properties. The purpose of this study was to examine the effects of takokak ethanol extract on TNF-α, IL6, and SOD levels.

Methods: Experimental factorial study design, with the effect of takokak extract concentration factor (0, 400 and 800 mg/kgBW), takokak extract administration time factor including preventive (weeks 1-7) and curative (weeks 6-12) administration, and necropsy factor (necropsy in weeks 12 and 16). The data obtained included rats body weight, TNF-α, IL-6 and SOD levels.

Results: The result showed that the interaction between takokak concentration and handling has significant effect on the increase of TNF-α levels (p=0.003) and the decrease of IL-6 levels (p=0.000). Interaction between takokak concentration, handling and necropsy has significant effect on the increase of SOD levels (p=0.010).

Conclusion: Takokak ethanol extract has significant effect on the increase of TNF-α, and SOD levels, and the decrease of IL-6 levels.

Keywords
Takokak (Solanum torvum); inflammation

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