skip to main content

Level of hsCRP Maternal Serum During Puerperium of Severe Preeclampsia

Faculty of Medicine Diponegoro University, Indonesia

Received: 5 Apr 2018; Published: 30 Jul 2018.
Open Access Copyright (c) 2018 Journal of Biomedicine and Translational Research

Citation Format:

Background: Preeclampsia and eclampsia arestill major problemsin the world. Maternal mortality of severe preeclampsia at the puerperal period is likely to be greater because of the cardiovascular diseases (CVD). HsCRP (high sensitivity C-Reactive Protein) is a usefull prediction for CVD among non preeclamptic patients. Before using hsCRP as a marker for that prediction of cardiovascular event from preeclamptic patient, we should do research to know difference of hsCRP between preeclampsia and normal pregnancy.

Objective: To determine the differences levels of hsCRP among severe preeclampsia and normal pregnancy

Method : A cross sectional study was conducted to severe preeclampsia. The inclusion criteria were subjects in puerperal period (2- 6 weeks) with a history of severe preeclampsia and normotensive.Exclusion criteria were puerperal infection, chronic hypertension, metabolic syndrome, caesarean section delivery and refuse to join this research. All subjects were examined the levels of hsCRP maternal serum when blood pressure £140 / 90.

Result: Subjects were consist of 26 severe preeclampsia (53%) and 23 normal pregnancy (46.9%). Level of hsCRP in severe preeclampsia was 4.73 +3.57while in normotensive 2.42 +4.14 (p <0.05). Severe preeclampsia group will increase the risk of hsCRP rise as much as 2.5 times compared to the normotensive group.

Conclusion:Level of hsCRP in patients with preeclampsia post partum were higher than patients with normal pregnancies.


Fulltext View|Download
Keywords: High Sensitivity C-Reactive Protein; severe preeclampsia; puerperal period

Article Metrics:

  1. World Health Organization. Maternal mortality. Avalaible from: Last accesessed: April 10, 2014. 2014
  2. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 2565 Tahun 2011.(The Ministry of Health Republic Indonesia. Regulation of the Health Minister of the Republic Indonesia No. 2565 Year 2011)
  3. Wikstrom A, Haglund B, Olovsson M, Lindeberg S. The Risk of Maternal Ischaemic Heart Disease after Hypertensive Disease. BJOG. 2005(112):1486-91
  4. Setiawan I, Wardhani V, Sargowo D. Akurasi Fibrinogen dan Hs-CRP sebagai Biomarker pada Sindroma Koroner Akut. J Kedokteran Brawijaya. 2011;26(4):233-9
  5. Fatemeh M, Fatemeh R, Hossian AK. Association of Maternal Serum C- Reactive Protein Levels with Severity of Preeclampsia. Acta Medica Iranica 2009;47(4):293-6
  6. Hwang HS, Kwon JY, Kim MA, Park YW, Kim YH. Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet. 2007;98(2):105-9
  7. Tavana ZM, Zholghadri JD. The Relationship between Maternal serum highly sensitive C-Reactive Protein, Leptin and Hypertensive disorder of Pregnancy. The Internet Journal of Endocrine. 2010;6(2)
  8. Romano M, Cacciatore A, Giordano R, La Rosa B. Postpartum period: three distinct but continuous phases. J Prenat Med. 2010;4(2):22-5
  9. Hubel CA, Powers RW, Snaedal S, Gammill HS, Ness RB, Roberts JM, et al. C-reactive protein is elevated 30 years after eclamptic pregnancy. Hypertension. 2008;51(6):1499-505
  10. Vallejo Vaz AJ, Guisado ML, Garcia-Junco PS, Andreu EP, Morillo SG, Ortiz JV. Differences in the prevalence of metabolic syndrome and levels of C-reactive protein after puerperium in women with hypertensive disorders during pregnancy. Hypertens Res. 2010;33(10):1012-7
  11. Ann-Charlotte I. Inflammatory mechanisms in preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2013;3(2):58

Last update:

No citation recorded.

Last update:

No citation recorded.