Level of hsCRP Maternal Serum During Puerperium  of Severe Preeclampsia

Julian Dewantiningrum; Zaki Hetami

doi:10.14710/jbtr.v4i1.2501

DOI: https://doi.org/10.14710/jbtr.v4i1.2501

Level of hsCRP Maternal Serum During Puerperium of Severe Preeclampsia

Julian Dewantiningrum , Zaki Hetami

Faculty of Medicine Diponegoro University, Indonesia

Received: 5 Apr 2018; Published: 30 Jul 2018.

BibTex Citation Data :

@article{JBTR2501,
    author = {Julian Dewantiningrum and Zaki Hetami},
    title = {Level of hsCRP Maternal Serum During Puerperium  of Severe Preeclampsia},
    journal = {Journal of Biomedicine and Translational Research},
  volume = {4},
    number = {1},
    year = {2018},
    keywords = {High Sensitivity C-Reactive Protein; severe preeclampsia; puerperal period},
    abstract = {  Background : Preeclampsia and eclampsia arestill major problemsin the world. Maternal mortality of severe preeclampsia at the puerperal period is likely to be greater because of the cardiovascular diseases (CVD). HsCRP (high sensitivity C-Reactive Protein) is a usefull prediction for CVD among non preeclamptic patients. Before using hsCRP as a marker for that prediction of cardiovascular event from preeclamptic patient, we should do research to know difference of hsCRP between preeclampsia and normal pregnancy.   Objective : To determine the differences levels of hsCRP among severe preeclampsia and normal pregnancy   Method  : A  cross sectional  study was conducted to severe preeclampsia. The inclusion criteria were subjects in puerperal period (2- 6 weeks) with a history of severe preeclampsia and normotensive.Exclusion criteria were puerperal infection, chronic hypertension, metabolic syndrome, caesarean section delivery and refuse to join this research. All subjects were examined the levels of hsCRP maternal serum when blood pressure £140 / 90.   Result : Subjects were consist of 26 severe preeclampsia (53%) and 23 normal pregnancy (46.9%). Level of hsCRP in severe preeclampsia was 4.73  + 3.57while in normotensive 2.42  + 4.14 (p <0.05). Severe preeclampsia group will increase the risk of hsCRP rise as much as 2.5 times compared to the normotensive group.   Conclusion :  Level of hsCRP in patients with preeclampsia post partum were higher than patients with normal pregnancies.    },
   issn = {2503-2178},   pages = {9--11}  doi = {10.14710/jbtr.v4i1.2501},
    url = {https://ejournal2.undip.ac.id/index.php/jbtr/article/view/2501}
}

Citation Format:

Abstract

Background: Preeclampsia and eclampsia arestill major problemsin the world. Maternal mortality of severe preeclampsia at the puerperal period is likely to be greater because of the cardiovascular diseases (CVD). HsCRP (high sensitivity C-Reactive Protein) is a usefull prediction for CVD among non preeclamptic patients. Before using hsCRP as a marker for that prediction of cardiovascular event from preeclamptic patient, we should do research to know difference of hsCRP between preeclampsia and normal pregnancy.

Objective: To determine the differences levels of hsCRP among severe preeclampsia and normal pregnancy

Method : A cross sectional study was conducted to severe preeclampsia. The inclusion criteria were subjects in puerperal period (2- 6 weeks) with a history of severe preeclampsia and normotensive.Exclusion criteria were puerperal infection, chronic hypertension, metabolic syndrome, caesarean section delivery and refuse to join this research. All subjects were examined the levels of hsCRP maternal serum when blood pressure £140 / 90.

Result: Subjects were consist of 26 severe preeclampsia (53%) and 23 normal pregnancy (46.9%). Level of hsCRP in severe preeclampsia was 4.73 +3.57while in normotensive 2.42 +4.14 (p <0.05). Severe preeclampsia group will increase the risk of hsCRP rise as much as 2.5 times compared to the normotensive group.

Conclusion:Level of hsCRP in patients with preeclampsia post partum were higher than patients with normal pregnancies.

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Keywords: High Sensitivity C-Reactive Protein; severe preeclampsia; puerperal period

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Section: Original Research Articles

Language : EN

In Vol 4, No 1 (2018): July 2018

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Ann-Charlotte I. Inflammatory mechanisms in preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2013;3(2):58

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