DOI: https://doi.org/10.14710/jbtr.v9i1.17379

Understanding Platelet-Rich Plasma as Potential Therapy To Improve Cardiac Function After Myocardial Infarction: Based On Evidence

1Department of Biomedical Science, Faculty of Medicine, Universitas Prima Indonesia, Indonesia

2Faculty of Medicine, Universitas Sumatera Utara, Indonesia

3Faculty of Medicine, Universitas Prima Indonesia, Indonesia

Received: 9 Feb 2023; Revised: 6 Apr 2023; Accepted: 14 Apr 2023; Available online: 30 Apr 2023; Published: 29 Apr 2023.
Open Access Copyright (c) 2023 Journal of Biomedicine and Translational Research
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract

Myocardial infarction is the leading cause of death in the world’s population. The sudden and progressive loss of cardiomyocyte contractile cells due to infarction is disproportionate to the number of new cells formation. This pathological condition will ultimately reduce the function of the heart muscles. Platelet-rich plasma (PRP) in the last decade has been attracting attention regarding its role in cell regeneration. The content of cytokines and growth factors contained in PRP such as Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor Beta 1 (TGF-Β1), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Basic Fibroblast Growth Factor (bFGF) and others are known to be involved in the migration, proliferation, and differentiation of various cell types and to induce post-ischemic angiogenesis. This review aims to analyze and investigate the benefits of PRP therapy in myocardial infarction. Recent literatures regarding the use of PRP in myocardial infarction was collected by searching PubMed and Google Scholar databases with the keywords of “Platelet-rich plasma”, “Myocardial Infarction”, “Reperfusion”, and “Angiogenesis”. The researches used was published between January 2011 and December 2022. Based on the results, Platelet-rich Plasma (PRP) is considered capable of accelerating angiogenesis, mitogenesis, protect cells from free radicals, reduce infarct area and scar tissue in myocardial infarction. PRP can also improve cardiac function in post myocardial infarction by increasing ejection fraction. In addition, PRP can also reduce treatment costs due to the risk of myocardial infarction complications such as bleeding and infection.

Note: This article has supplementary file(s).

Fulltext View|Download |  Transcripts
Understanding Platelet-Rich Plasma as Potential Therapy To Improve Cardiac Function After Myocardial Infarction: Based On Evidence
Subject Platelet-rich plasma; Myocardial Infarction; Angiogenesis; Cardiac function
Type Transcripts
  Download (49KB)    Indexing metadata
 Cover Letter
Cover letter + List of Reviewers
Subject
Type Cover Letter
  Download (17KB)    Indexing metadata
Keywords: Platelet-rich plasma; Myocardial Infarction; Angiogenesis; Cardiac function

Article Metrics:

Article Info
Section: Review Articles
Language : EN
Recent articles
Effect of Probiotic Supplementation on FSH, LH Levels and Folliculogenesis Potential of B-Cell Epitopes Protein Ag85 Complex Mycobacterium Tuberculosis as Serodiagnostic Antigen of Tuberculosis by in Silico Study Effects of Fermented Tempeh Using Rhizopus oligosporus and Lactobacillus rhamnosus GG on Body Weight, Lee Index, High Sensitivity C Reactive Protein and Lipid Profile of Obese Rats Understanding Platelet-Rich Plasma as Potential Therapy To Improve Cardiac Function After Myocardial Infarction: Based On Evidence More recent articles
  1. Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi SK, AlKatheeri R, Alblooshi FM, Almatrooshi ME, Alzaabi ME, Al Darmaki RS, Lootah SN. Global epidemiology of ischemic heart disease: Results from the global burden of disease study. Cureus. 2020 Jul;12(7). DOI: https://doi.org/10.7759/cureus.9349
  2. Giacca M. Cardiac regeneration after myocardial infarction: an approachable goal. Current Cardiology Reports. 2020 Oct;22(10):1-8. DOI: https://doi.org/10.1007/s11886-020-01361-7PMid:32778947PMCid:PMC7417409
  3. Minicucci MF, Azevedo PS, Polegato BF, Paiva SAR, Zornoff LAM. Heart failure after myocardial infarction: clinical implications and treatment. Clin Cardiol (2011) 34(7):410-4. DOI: https://doi.org/10.1002/clc.20922PMid:21688276PMCid:PMC6652587
  4. Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012;28(3):429-439. DOI: https://doi.org/10.1016/j.arthro.2011.10.018PMid:22284405
  5. Walsh TG, Poole AW. Do platelets promote cardiac recovery after myocardial infarction: roles beyond occlusive ischemic damage. American Journal of Physiology-Heart and Circulatory Physiology. 2018 May 1;314(5):H1043-8. DOI: https://doi.org/10.1152/ajpheart.00134.2018PMid:29547023PMCid:PMC6008147
  6. Lee JW, Kwon OH, Kim TK, Cho YK, Choi KY, Chung HY, et al. Platelet-rich plasma: quantitative assessment of growth factor levels and comparative analysis of activated and inactivated groups. Archives of plastic surgery. 2013; 40(5):530-5. DOI: https://doi.org/10.5999/aps.2013.40.5.530PMid:24086805PMCid:PMC3785585
  7. Andia, I. & Abate, M., 2013. Platelet-rich plasma: underlying biology and clinical correlates. Regenerative Medicine, 8, pp.645-658. DOI: https://doi.org/10.2217/rme.13.59PMid:23998756
  8. De Pascale, M. R., Sommese, L., Casamassimi, A. & Napoli, C. Platelet derivatives in regenerative medicine: an update. Transfus Med Rev 29, 52-61 (2015). DOI: https://doi.org/10.1016/j.tmrv.2014.11.001PMid:25544600
  9. Burnouf, T., Strunk, D., Koh, M. B. & Schallmoser, K. Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation? Biomaterials 76, 371-387 (2016). DOI: https://doi.org/10.1016/j.biomaterials.2015.10.065PMid:26561934
  10. Mishra A, Velotta J, Brinton TJ, Wang X, Chang S, Palmer O, Sheikh A, Chung J, Yang PC, Robbins R, Fischbein M. RevaTen platelet-rich plasma improves cardiac function after myocardial injury. Cardiovascular Revascularization Medicine. 2011 May 1;12(3):158-63. DOI: https://doi.org/10.1016/j.carrev.2010.08.005PMid:21122486
  11. Cheng K, Malliaras K, Shen D, Tseliou E, Ionta V, Smith J, Galang G, Sun B, Houde C, Marbán E. Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction. J Am Coll Cardiol. 2012 Jan 17;59(3):256-64. DOI: https://doi.org/10.1016/j.jacc.2011.10.858PMid:22240131PMCid:PMC3581074
  12. Matsui M, Tabata Y. Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels. Acta biomaterialia. 2012 May 1;8(5):1792-801. DOI: https://doi.org/10.1016/j.actbio.2012.01.016PMid:22293581
  13. Vu, T.D., Pal, S.N., Ti, L.K., Martinez, E.C., Rufaihah, A.J., Ling, L.H., Lee, C.N., Richards, A.M. and Kofidis, T., 2015. An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal "Myocardial Repair: PRP, Hydrogel and Supplements". Biomaterials, 45, pp.27-35. DOI: https://doi.org/10.1016/j.biomaterials.2014.12.013PMid:25662492
  14. Hehanusa RR, Andrianto A, Pikir BS. Effect of Platelet Rich Plasma on Proliferation of Endothelial Progenitor Cell (EPC) of Stable Coronary Artery Disease Patient. Indonesian Journal of Cardiology. 2019 Sep 11;40(2). DOI: https://doi.org/10.30701/ijc.v40i2.851
  15. Suryawan IG, Andrianto A, Anggaraeni AD, Agita A, Nugraha RA. The Role of Human Platelet-Rich Plasma to Enhance the Differentiation from Adipose derived Mesenchymal Stem Cells into Cardiomyocyte: An Experimental Study. bioRxiv. 2021 Jan 1:2020-12. DOI: https://doi.org/10.1101/2020.12.10.420679
  16. Torabi M, Abazari MF, Zare Karizi S, Kohandani M, Hajati‐Birgani N, Norouzi S, Nejati F, Mohajerani A, Rahmati T, Mokhames Z. Efficient cardiomyocyte differentiation of induced pluripotent stem cells on PLGA nanofibers enriched by platelet‐rich plasma. Polymers for Advanced Technologies. 2021 Mar;32(3):1168-75. DOI: https://doi.org/10.1002/pat.5164
  17. Ozcelik U, Ekici Y, Bircan HY, Aydogan C, Turkoglu S, Ozen O. Effect of topical plateletrich plasma on burn healing after partial-thickness burn injury. Med Sci Monit. 2016;22:1903-9. DOI: https://doi.org/10.12659/MSM.895395PMid:27262706PMCid:PMC4913826
  18. Bir SC, Esaki J, Marui A, Sakaguchi H, Kevil CG, Ikeda T, Komeda M, Tabata Y, Sakata R. Therapeutic treatment with sustained-release platelet-rich plasma restores blood perfusion by augmenting ischemia-induced angiogenesis and arteriogenesis in diabetic mice. Journal of vascular research. 2011;48(3):195-205. DOI: https://doi.org/10.1159/000318779PMid:21099226
  19. Karina KA, Sobariah S, Rosliana I, Rosadi I, Widyastuti T, Afini I, Wanandi SI, Soewondo P, Wibowo H, Pawitan JA. Evaluation of platelet-rich plasma from diabetic donors shows increased platelet vascular endothelial growth factor release. Stem cell investigation. 2019;6. DOI: https://doi.org/10.21037/sci.2019.10.02PMid:32039265PMCid:PMC6987324
  20. Cai TQ, Wickham LA, Sitko G, Michener MS, Raubertas R, Handt L, Chintala M, Seiffert D, Forrest M. Platelet transfusion reverses bleeding evoked by triple anti-platelet therapy including vorapaxar, a novel platelet thrombin receptor antagonist. European journal of pharmacology. 2015 Jul 5;758:107-14. DOI: https://doi.org/10.1016/j.ejphar.2015.03.073PMid:25857224
  21. Alsousou J, Ali A, Willett K, Harrison P. The role of platelet-rich plasma in tissue regeneration. Platelets. 2013 May 1;24(3):173-82. DOI: https://doi.org/10.3109/09537104.2012.684730PMid:22647081
  22. Rosadi I, Karina K, Rosliana I, Sobariah S, Afini I, Widyastuti T, Barlian A. In vitro study of cartilage tissue engineering using human adipose-derived stem cells induced by platelet-rich plasma and cultured on silk fibroin scaffold. Stem cell research & therapy. 2019 Dec;10(1):1- 5. DOI: https://doi.org/10.1186/s13287-019-1443-2PMid:31801639PMCid:PMC6894137
  23. Gallo I, Sáenz A, Artinano E, Esquide J. Autologous platelet-rich plasma: effect on sternal healing in the sheep model. Interactive cardiovascular and thoracic surgery. 2010 Sep 1;11(3):223-5. DOI: https://doi.org/10.1510/icvts.2010.237776PMid:20591889
  24. Sanchez-Gonzalez DJ, Mendez-Bolaina E, Trejo-Bahena NI. Platelet-rich plasma peptides: key for regeneration. International journal of peptides. 2012; 2012:532519. DOI: https://doi.org/10.1155/2012/532519PMid:22518192PMCid:PMC3303558
  25. Ahmad Z, Howard D, Brooks RA, Wardale J, Henson FM, Getgood A, et al. The role of platelet rich plasma in musculoskeletal science. JRSM short reports. 2012; 3(6):40. DOI: https://doi.org/10.1258/shorts.2011.011148PMid:22768374PMCid:PMC3386662
  26. Samy A, El-Adl M, Rezk S, Marghani B, Eldomany W, Eldesoky A, Elmetwally MA. The potential protective and therapeutic effects of platelet-rich plasma on ischemia/reperfusion injury following experimental torsion/detorsion of testis in the Albino rat model. Life sciences. 2020 Sep 1;256:117982. DOI: https://doi.org/10.1016/j.lfs.2020.117982PMid:32562693
  27. Matsui M, Tabata Y. Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels. Acta biomaterialia. 2012 May 1;8(5):1792-801. DOI: https://doi.org/10.1016/j.actbio.2012.01.016PMid:22293581
  28. Karina K, Biben JA, Ekaputri K, Rosadi I, Rosliana I, Afini I, Widyastuti T, Sobariah S, Subroto WR. In vivo study of wound healing processes in Sprague-Dawley model using human mesenchymal stem cells and platelet-rich plasma. Biomedical Research and Therapy. 2021 Apr 30;8(4):4316-24. DOI: https://doi.org/10.15419/bmrat.v8i4.670
  29. Moog P, Kirchhoff K, Bekeran S, Bauer AT, von Isenburg S, Dornseifer U, Machens HG, Schilling AF, Hadjipanayi E. Comparative evaluation of the angiogenic potential of hypoxia preconditioned blood-derived secretomes and platelet-rich plasma: An in vitro analysis. Biomedicines. 2020 Jan;8(1):16. DOI: https://doi.org/10.3390/biomedicines8010016PMid:31963131PMCid:PMC7168246
  30. Etulain J, Mena HA, Meiss RP, Frechtel G, Gutt S, Negrotto S, Schattner M. An optimised protocol for platelet-rich plasma preparation to improve its angiogenic and regenerative properties. Scientific reports. 2018 Jan 24;8(1):1-5. DOI: https://doi.org/10.1038/s41598-018-19419-6PMid:29367608PMCid:PMC5784112
  31. Oneto P, Zubiry PR, Schattner M, Etulain J. Anticoagulants interfere with the angiogenic and regenerative responses mediated by platelets. Frontiers in bioengineering and biotechnology. 2020 Mar 20;8:223. DOI: https://doi.org/10.3389/fbioe.2020.00223PMid:32266247PMCid:PMC7098916
  32. Ahmed M, Reffat SA, Hassan A, Eskander F. Platelet-rich plasma for the treatment of clean diabetic foot ulcers. Annals of vascular surgery. 2017 Jan 1;38:206-11. DOI: https://doi.org/10.1016/j.avsg.2016.04.023PMid:27522981
  33. Karina MF, Rosadi I, Afini I, Widyastuti T, Sobariah S, Remelia M, Puspitasari RL, Rosliana I, Tunggadewi TI. Combination of the stromal vascular fraction and platelet-rich plasma accelerates the wound healing process: pre-clinical study in a Sprague-Dawley rat model. Stem cell investigation. 2019;6. DOI: https://doi.org/10.21037/sci.2019.06.08PMid:31463311PMCid:PMC6691081
  34. Sharma D, Agarwal P, Jain S, Kothari R. Autologous platelet-rich plasma for treatment of ischemic ulcers in buerger's disease: A pilot study with short-term results. Indian Journal of Vascular and Endovascular Surgery. 2018 Jan 1;5(1):14. DOI: https://doi.org/10.4103/ijves.ijves_47_17
  35. Gyulkhandanyan AV, Allen DJ, Mykhaylov S, Lyubimov E, Ni H, Freedman J, Leytin V. Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis : Disclosure of Nonapoptotic Membrane Depolarization. Clin Appl Thromb Hemost. 2017 Mar;23(2):139-147. DOI: https://doi.org/10.1177/1076029616665924PMid:27637909
  36. Zhang Y, Ying G, Ren C, Jizhang Y, Brogan D, Liu Z, Li S, Ding Y, Borlongan CV, Zhang J, Ji X. Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke. Brain research. 2015 Jan 12;1594:267-73. DOI: https://doi.org/10.1016/j.brainres.2014.10.035PMid:25452023
  37. Hirt MN, Hansen A, Eschenhagen T. Cardiac tissue engineering: state of the art. Circulation research. 2014 Jan 17;114(2):354-67. DOI: https://doi.org/10.1161/CIRCRESAHA.114.300522PMid:24436431
  38. Goradel NH, Hour FG, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A, Mirzaei H. Stem cell therapy: a new therapeutic option for cardiovascular diseases. Journal of cellular biochemistry. 2018 Jan;119(1):95-104. DOI: https://doi.org/10.1002/jcb.26169PMid:28543595
  39. Mullen L, Meah MN, Elamin A, Aggarwal S, Shahzad A, Shaw M, Hasara J, Rashid M, Fisher M, Ali T, Patel B. Risk of Major Bleeding With Potent Antiplatelet Agents After an Acute Coronary Event: A Comparison of Ticagrelor and Clopidogrel in 5116 Consecutive Patients in Clinical Practice. Journal of the American Heart Association. 2021 Apr 20;10(8):e019467. DOI: https://doi.org/10.1161/JAHA.120.019467PMid:33834845PMCid:PMC8174168
  40. Cai TQ, Wickham LA, Sitko G, Michener MS, Raubertas R, Handt L, Chintala M, Seiffert D, Forrest M. Platelet transfusion reverses bleeding evoked by triple anti-platelet therapy including vorapaxar, a novel platelet thrombin receptor antagonist. European journal of pharmacology. 2015 Jul 5;758:107-14. DOI: https://doi.org/10.1016/j.ejphar.2015.03.073PMid:25857224
  41. Karina K, Ekaputri K, Biben JA, Purwoko RH, Sibuea TP, Astuti SL, Loho AM, Limengka Y, Agustini S, Krisandi G, Maryam A. Evaluating the Safety of Intravenous Delivery of Autologous Activated Platelet-rich Plasma. Journal of Health Sciences. 2020. DOI: https://doi.org/10.17532/jhsci.2021.1276
  42. Patel AN, Selzman CH, Kumpati GS, McKellar SH, Bull DA. Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients. Journal of cardiothoracic surgery. 2016 Dec;11(1):1-6. DOI: https://doi.org/10.1186/s13019-016-0452-9PMid:27068030PMCid:PMC4828785
  43. Karina K, Rosliana I, Rosadi I, Sobariah S, Christoffel LM, Novariani R, Rosidah S, Fatkhurohman N, Hertati Y, Puspitaningrum N, Subroto WR. Phase I/II Clinical Trial of Autologous Activated Platelet-Rich Plasma (aaPRP) in the Treatment of Severe Coronavirus Disease 2019 (COVID-19) Patients. International Journal of Inflammation. 2021 Jul 9;2021. DOI: https://doi.org/10.1155/2021/5531873PMid:34306612PMCid:PMC8285191
  44. Rah DK, Min HJ, Kim YW, Cheon YW. Effect of platelet-rich plasma on ischemiareperfusion injury in a skin flap mouse model. International journal of medical sciences. 2017;14(9):829 DOI: https://doi.org/10.7150/ijms.19573PMid:28824320PMCid:PMC5562190
  45. Bakacak M, Bostanci MS, İnanc F, Yaylali A, Serin S, Attar R, Yildirim G, Yildirim OK. Protective effect of platelet rich plasma on experimental ischemia/reperfusion injury in rat ovary. Gynecologic and obstetric investigation. 2016;81(3):225-31. DOI: https://doi.org/10.1159/000440617PMid:26496072
  46. Kurita J, Miyamoto M, Ishii Y, Aoyama J, Takagi G, Naito Z, Tabata Y, Ochi M, Shimizu K. Enhanced vascularization by controlled release of platelet-rich plasma impregnated in biodegradable gelatin hydrogel. The Annals of thoracic surgery. 2011 Sep 1;92(3):837-44. DOI: https://doi.org/10.1016/j.athoracsur.2011.04.084PMid:21871267
  47. Bir SC, Esaki J, Marui A, Sakaguchi H, Kevil CG, Ikeda T, Komeda M, Tabata Y, Sakata R. Therapeutic treatment with sustained-release platelet-rich plasma restores blood perfusion by augmenting ischemia-induced angiogenesis and arteriogenesis in diabetic mice. Journal of vascular research. 2011;48(3):195-205. DOI: https://doi.org/10.1159/000318779PMid:21099226
  48. Martin-Sole O, Rodo J, Garcia-Aparicio L, Blanch J, Cusi V, Albert A. Effects of plateletrich plasma (PRP) on a model of renal ischemia-reperfusion in rats. PLoS One. 2016 Aug 23;11(8):e0160703. DOI: https://doi.org/10.1371/journal.pone.0160703PMid:27551718PMCid:PMC4994962

Last update:

No citation recorded.

Last update:

No citation recorded.