DOI: https://doi.org/10.14710/jbtr.v7i2.11821

The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth

Faculty of Medicine, Universitas Diponegoro, Indonesia

Received: 25 Jul 2021; Revised: 27 Aug 2021; Accepted: 27 Aug 2021; Available online: 31 Aug 2021; Published: 31 Aug 2021.
Open Access Copyright (c) 2021 Journal of Biomedicine and Translational Research
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Background: Leptin plays an important role in regulating body weight, metabolism, and reproductive functions. Leptin affects metabolism by reducing nutrient intake and increasing energy expenditure which eventually also plays a role in infant growth.

Objective: This study aims to determine the relationship between leptin levels and infant growth age 0-6 months.

Methods: A prospective cohort study was done for six months on 38 infants, age 0-6 months, from breastfeeding mothers with normal pregnancies. The samples were taken twice, firstly when the infant was born using an umbilical cord blood sample, and secondly at the age of six months, using a vein blood sample. Serum leptin levels were measured using the ELISA method. Infant growth was assessed using WHO 2005’s z-scores.

Results: A total of 50 babies were included in the study, 38 of them had been studied completely. Significant correlations were found between the mean of the umbilical cord and six months of age leptin levels (p <0.001), between delta leptin with WHZ and delta leptin with WAZ at six months of age (p = 0.002 and p = 0.003, respectively), and between leptin levels with WHZ (p<0.001) and leptin levels with WAZ (p = 0.004) at six months of age. Leptin levels at the age of six months are lower than umbilical cord blood leptin. 

Conclusion: The greater decrease of leptin level in the first six months is associated with better infant growth.

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Keywords: leptin; cord blood leptin; infant growth

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Section: Original Research Articles
Language : EN
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  1. Wen X, Gillman MW, Taveras EM, Wen X, Kleinman K, Gillman MW, et al. Childhood body mass index trajectories : modeling , characterizing , pairwise correlations and socio- demographic predictors of trajectory characteristics Childhood body mass index trajectories : modeling , characterizing , pairwise correlations and socio. BMC Med Res Methodol. 2012;12(38):1–13
  2. Murray PG, Clayton PE. Endocrine Control of Growth. Am J Med Genet Part C Semin Med Genet. 2013;163C:76–85
  3. Mook-kanamori DO, Durmus B, Sovio U, Hofman A, Raat H, Steegers EA, et al. Fetal and infant growth and the risk of obesity during early childhood : the Generation R Study. Eur J Endocrinol. 2011;165:623–30
  4. Wang G, Johnson S, Gong Y, Polk S, Divall S, Radovick S, et al. Weight Gain in Infancy and Overweight or Obesity in Childhood across the Gestational Spectrum : a Prospective Birth Cohort Study. Sci Rep [Internet]. 2016;6(29867):1–10. Available from: http://dx.doi.org/10.1038/srep29867
  5. Savino F, Rossi L, Benetti S, Petrucci E, Sorrenti M, Silvestro L. Serum Reference Values for Leptin in Healthy Infants. PLoS One. 2014;9(11):1–6
  6. Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, et al. Ghrelin, Leptin, IGF-1, IGFBP-3, and Insulin Concentrations at Birth: Is There a Relationship with Fetal Growth and Neonatal Anthropometry? Clin Chem. 2008;54(3):550–8
  7. Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim S, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011;301:E567–84
  8. Swieten MMH Van, Pandit R, Adan RAH, Plasse G Van Der. The neuroanatomical function of leptin in the hypothalamus. J Chem Neuroanat [Internet]. 2014;1–14. Available from: http://dx.doi.org/10.1016/j.jchemneu.2014.05.004
  9. Much D, Br M, Sedlmeier E, Brunner S, Schmid D, Kristina H, et al. Effect of Reducing the n-6 / n-3 Fatty Acid Ratio on the Maternal and Fetal Leptin Axis in Relation to Infant Body Composition. Obesity. 2014;22:217–24
  10. Chaoimh C, Murray DM, Kenny LC, Irvine AD, Hourihane JOB, Kiely M. Cord blood leptin and gains in body weight and fat mass during infancy. Eur J Endocrinol. 2016;175:403–10
  11. Ong KK, Ahmed ML, Sherriff A, Woods KA, Angie W, Jean G, et al. Cord Blood Leptin is Associated with Size at Birth and Predicts Infancy Weight Gain in Humans. J Clin Endocrinol Metab. 1999;84(3):1145–8
  12. Caroline E, Mantzoros CS, Hughes MD, Rifas-shiman SL, Villamor E, Zera CA. Differential associations of leptin with adiposity across early childhood. Obes (Silber Spring). 2013;21(7):1430–7
  13. Nunes M, Homrich C, Bosa VL, Bernardi JR, Cristina I, Werlang R, et al. Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants ? BMC Pregnancy Childbirth. 2017;17(410):1–7
  14. Lönnerdal B, Havel PJ. Serum leptin concentrations in infants : effects of diet, sex, and adiposity. Am J Clin Nutr. 2000;72:484–9
  15. Schuster S, Hechler C, Gebauer C, Kiess W, Kratzsch J. Leptin in Maternal Serum and Breast Milk : Association With Infants ’ Body Weight Gain in a Longitudinal Study Over 6 Months of Lactation. Pediatr Res. 2011;70(6):633–7
  16. Yu X, Rong SS, Sun X, Ding G, Wan W, Zou L, et al. Associations of breast milk adiponectin , leptin , insulin and ghrelin with maternal characteristics and early infant growth : a longitudinal study. Br J Nutr. 2018;120:1380–7
  17. Doneray H, Orbak Z, Yildiz L. The relationship between breast milk leptin and neonatal weight gain. Acta Paediatr. 2009;98:643–7
  18. Mantzoros CS, Sweeney L, Williams CJ, Oken E, Kelesidis T, Rifas-Shiman SL, et al. Maternal diet and cord blood leptin and adiponectin concentrations at birth. Clin Nutr 2010;29:622-6
  19. Euclydes VLV, Castro NP, Lima LR, Brito C, Ribeiro L, Simoes FA, et al. Cord blood concentrations of leptin, zinc-α2-glycoprotein, and adiponectin, and adiposity gain during the first 3 mo of life. Nutrition 2018; 54:89-93
  20. Chan D, Goruk S, Becker AB, Subbarao P, Mandhane PJ, Turvey SE, et al. Adiponectin, leptin and insulin in breast milk : associations with maternal characteristics and infant body composition in the first year of life. Int J Obes [Internet]. 2018;42(1):36–43. Available from: http://dx.doi.org/10.1038/ijo.2017.189
  21. Karakosta P, Roumeliotaki T, Chalkiadaki G, Sarri K, Vassilaki M, Venihaki M. Cord blood leptin levels in relation to child growth trajectories. Metabolism 2016;65(6):874-82
  22. Mellati AA, Mazloomzadeh S, Anjomshoaa A, Alipour M, Karimi F, Mazloomi S, et al
  23. Multiple correlations between cord blood leptin concentration and indices of neonatal growth. Archives of Medical Research 2010;41:26-32
  24. Martinez-Cordero C, Amador-Licona N, Guizar-Mendoza JM, Hernandez-Mendez J, Ruelas-Orozco G. Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and Insulin-like growth cactor-I in small-for-gestational-age infants. Arch Med Res 2006;37:490-4
  25. Wang L, Mu S, Cheng I, Chen Y, Chen B, Jow G. Decreased leptin concentration in neonates is associated with enhanced postnatal growth during the first year. Kaohsiung J Med Sci [Internet]. 2012;28(10):521–5. Available from: http://dx.doi.org/10.1016/j.kjms.2012.04.013
  26. . Arsenault JE, Havel PJ, Lo D, Brown KH. Longitudinal measures of circulating leptin and ghrelin concentrations are associated with the growth of young Peruvian children but are not affected by zinc supplementation. Am J Clin Nutr. 2007;86(4):1111–9

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