BibTex Citation Data :
@article{jekk32541, author = {Murni lestari and muhammad Fachri and Nurmalia Lusida}, title = {Urban Pm2.5 Exposure And Placental Dysfunction And Its Impact On Fetal Development}, journal = {Jurnal Epidemiologi Kesehatan Komunitas}, volume = {11}, number = {3}, year = {2026}, keywords = {}, abstract = { Background: Exposure to particulate matter (PM2.5) measuring ≤2.5 micrometers in Indonesia continues to increase. Particularly in urban areas, severe air pollution is a significant issue in maternal and perinatal health due to its potential for adverse effects during pregnancy. Exposure to PM2.5 is known to be associated with impaired placental function through inflammatory mechanisms, increased oxidative stress, and vascular dysfunction, which can reduce uteroplacental perfusion and inhibit optimal fetal growth and development Objective This systematic review aims to analyze and examine the relationship between PM2.5 exposure and placental dysfunction and the impact of fetal development based on a systematic review based on the latest literature review. Methods PRISMA 2020-based systemic literature review of PubMed and Scopus, ScienceDirect, with thematic synthesis. Result: Of the 2,845 articles, 21 met the inclusion criteria. The most consistent research evidence indicates that exposure to PM2.5 in the first to mid-trimester of pregnancy is associated with placental inflammation, increased oxidative stress, and impaired uteroplacental perfusion. These conditions can inhibit fetal growth and development, increasing the risk of low birth weight (LBW), intrauterine growth restriction (IUGR), and preterm birth. Conclusion : Exposure to PM2.5 during pregnancy is associated with placental dysfunction through inflammatory and oxidative stress mechanisms which ultimately have a negative impact on fetal growth and developmen. Keywords: PM2.5, Pregnancy, Placental dysfunction, Fetal development. }, issn = {2615-4854}, doi = {10.14710/jekk.v11i3.32541}, url = {https://ejournal2.undip.ac.id/index.php/jekk/article/view/32541} }
Refworks Citation Data :
Background: Exposure to particulate matter (PM2.5) measuring ≤2.5 micrometers in Indonesia continues to increase. Particularly in urban areas, severe air pollution is a significant issue in maternal and perinatal health due to its potential for adverse effects during pregnancy. Exposure to PM2.5 is known to be associated with impaired placental function through inflammatory mechanisms, increased oxidative stress, and vascular dysfunction, which can reduce uteroplacental perfusion and inhibit optimal fetal growth and development Objective This systematic review aims to analyze and examine the relationship between PM2.5 exposure and placental dysfunction and the impact of fetal development based on a systematic review based on the latest literature review.
Methods PRISMA 2020-based systemic literature review of PubMed and Scopus, ScienceDirect, with thematic synthesis.
Result: Of the 2,845 articles, 21 met the inclusion criteria. The most consistent research evidence indicates that exposure to PM2.5 in the first to mid-trimester of pregnancy is associated with placental inflammation, increased oxidative stress, and impaired uteroplacental perfusion. These conditions can inhibit fetal growth and development, increasing the risk of low birth weight (LBW), intrauterine growth restriction (IUGR), and preterm birth.
Conclusion : Exposure to PM2.5 during pregnancy is associated with placental dysfunction through inflammatory and oxidative stress mechanisms which ultimately have a negative impact on fetal growth and developmen.
Keywords: PM2.5, Pregnancy, Placental dysfunction, Fetal development.
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