Effect of Nigella Sativa on IL-10 in MB Leprosy that Received MDT-WHO Therapy

*Febrina Primasanti -  dr. Kariadi Semarang Hospital, Indonesia
Lewie Suryaatmadja -  Faculty of Medicine Diponegoro University, Indonesia
R. Sri Djoko -  Faculty of Medicine Diponegoro University, Indonesia
Received: 8 Mar 2016; Published: 30 Jul 2016.
Open Access
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Section: Original Research Articles
Language: EN
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Abstract

Background: Leprosy, a chronic infectious disease presents a broad clinical spectrum that is correlated with the immunological response of the patient, mainly related to Th1/Th2 cells. IL-10 is a major cytokine produced by Th2 cells inhibits imunostimulatory cytokine produced by Th1 cells. Suppressive effects of IL-10 in monocytes and cytokine synthesis by Th1 cells presumably because IL-10 has a general suppressive effect on immune function. Nigella sativa has a potent potentiating effect on cellular immunity through suppression of Th2 cells and IL-10, resulting in potentiation of Th1 cells.
Method
: The study design is a randomized pretest and posttest controlled design involving 40 subjects of MB leprosy patients. Serum levels of IL-10 were measured by ELISA.
Result: The mean decrease in serum levels of IL-10 (IL-10 delta) in the treatment group (average fell 3.12 pg/ml) is greater than the control group (average rose 0.21 pg/ml), where the difference is statistically significant (p = 0.029). Nigella sativa giving significant correlation with a decrease in IL-10 compared to the control group (p=0.044, OR: 10.23).
Conclusion: supplementation of Nigella sativa 3 x 1000 mg for 2 months in patients with MB leprosy can reduce levels of IL-10, thus increasing the cellular immune response in patients with MB leprosy.

Keywords
MB Leprosy; Nigella sativa; IL-10

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