DOI: https://doi.org/10.14710/jbtr.v10i2.21211

Revealing the Potency of Camelia sinensis and Serenoa repens as Purinoreceptor Inhibitor for Benign Prostatic Hyperplasia Treatment through in Silico Study

1General Practitioner of Public Health Center of Kunir, Indonesia

2Department of Urology, Faculty of Medicine, Universitas Brawijaya, Indonesia

Received: 6 Dec 2023; Accepted: 13 Aug 2024; Available online: 30 Aug 2024; Published: 30 Aug 2024.
Open Access Copyright (c) 2024 Journal of Biomedicine and Translational Research
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Background: Benign prostatic hyperplasia (BPH) is the most common prostate disease in elderly men that leads to a significant deterioration in patients' quality of life (QoL). Pharmacological therapy of 5-alpha reductase inhibitor and alpha adrenoreceptors blocker often causes several side effects that decrease the QoL, so it is necessary to develop a new treatment for BPH. Purinoreceptor is a novel receptor that can inhibit electrically evoked nerve-mediated contractions in the prostate. Tea leaves (Camellia sinensis) and Saw palmetto (Serenoa repens) are herbs that have potential as alternative therapies for BPH

Objective: to reveal the mechanism of Camellia sinensis and Serenoa repens through purinoreceptor and the other receptors

Methods: Structures of active compounds were extracted from PubChem and protein from PBD. The active compounds Camellia sinensis and Serenoa repens to the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors was evaluated in silico using a docking server with Finasteride dan Tamsolusin as a control. Molecular docking method using dockingserver application.

Results: Epigallocatechin gallate only compound that has potency in blocking purinoceptors and 5-alpha-reductase. Capric acid, Caprylic acid, Lauric acid, Linoleic acid, and Myristic acid have the potential to bind to alpha adrenoreceptor ligands.

Conclusion: Camellia sinensis have potential and effects as alternative therapies in benign prostatic hyperplasia on the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors. But, Serenoa repens have potential only through alpha adrenoreceptors.

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Keywords: Camellia sinensis, Serenoa repens, Benign prostatic hyperplasia, In silico, Purinoreceptor

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Section: Original Research Articles
Language : EN
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  8. Katz A, Efros M, Kaminetsky J, Herrlinger K, Chirouzes D, Ceddia M. A green and black tea extract benefits urological health in men with lower urinary tract symptoms. Ther Adv Urol. 2014 Jun;6(3):89-96. doi: 10.1177/1756287214526924.PMID:24883106;PMCID:PMC4003843
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  10. Koch W, Zagórska J, Marzec Z, Kukula-Koch W. Applications of Tea (Camellia sinensis) and its Active Constituents in Cosmetics. Molecules. 2019 Nov 24;24(23):4277. doi: 10.3390/molecules24234277.PMID:31771249;PMCID:PMC6930595
  11. Chua T, Eise NT, Simpson JS, Ventura S. Pharmacological characterization and chemical fractionation of a liposterolic extract of saw palmetto (Serenoa repens): effects on rat prostate contractility. J Ethnopharmacol. 2014 Mar 14;152(2):283-91. doi: 10.1016/j.jep.2013.12.030.Epub2014Jan21.PMID:24463033
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  19. North, R Alan, and Michael F Jarvis. “P2X receptors as drug targets.” Molecular pharmacology vol. 83,4 (2013): 759-69. doi: 10.1124/mol.112.083758
  20. Alsufyani, H. A., & Docherty, J. R. (2021). Roles for α1-adrenoceptors during contractions by electrical field stimulation in mouse vas deferens. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 25(6), 525–532. https://doi.org/10.4196/kjpp.2021.25.6.525
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  24. Dunn, C. J., Matheson, A., and Faulds, D. M, 2002. Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs & aging, 19(2)
  25. Du, X., Li, Y., Xia, Y. L., Ai, S. M., Liang, J., Sang, P., Ji, X. L., dan Liu, S. Q, 2016. Insights into Protein-Ligand Interactions: Mechanisms, Models, and Methods. International journal of molecular sciences, 17(2), 144

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