Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

Eriawan Agung Nugroho; Rickky Kurniawan

doi:10.14710/jbtr.v3i2.1971

DOI: https://doi.org/10.14710/jbtr.v3i2.1971

Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

Eriawan Agung Nugroho, Rickky Kurniawan

Faculty of Medicine Diponegoro University, Indonesia

Received: 15 Dec 2017; Published: 31 Dec 2017.

BibTex Citation Data :

@article{JBTR1971,
    author = {Eriawan Nugroho and Rickky Kurniawan},
    title = {Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study},
    journal = {Journal of Biomedicine and Translational Research},
  volume = {3},
    number = {2},
    year = {2017},
    keywords = {hyperglycemia; benign prostate enlargement},
    abstract = {  Introduction:  Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of  benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.     Me  thod:  We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The  presence  of  hyperglycemia  was  determined  based  on  the  American  Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.   Result  s:  Significant difference of prostate volume found between groups. Prostate volume was  significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained  Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive association   Conclusion:  Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor  for  prostate  enlargement  in  patients  with  benign  prostate  enlargement  in dr. Kariadi Hospital Semarang. },
   issn = {2503-2178},   pages = {46--49}  doi = {10.14710/jbtr.v3i2.1971},
    url = {https://ejournal2.undip.ac.id/index.php/jbtr/article/view/1971}
}

Citation Format:

Abstract

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.

Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The presence of hyperglycemia was determined based on the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.

Results: Significant difference of prostate volume found between groups. Prostate volume was significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive association

Conclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor for prostate enlargement in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.

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Keywords: hyperglycemia; benign prostate enlargement

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Section: Original Research Articles

Language : EN

In Vol 3, No 2 (2017): December 2017

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Suwandi Sugandi. Anatomi dan Fisiologi Kelenjar Prostat serta Kontrol Hormonal terhadap Fungsi Prostat. 2007. URL : http://www.urologi.or.id
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Walsh, Patrick C. Benign prostatic hyperplasia. In : Campbell’s Urology. 6th ed. W.B. Saunders ; 2015. p.1009-1025Kasper JS, Giovannucci E. A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiology Biomarkers & Prevention. 2006;15:2056–2062
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Parson., Aruna., F. Olumi., Aria. Diabetes, growth hormone-insuline-like growth factor pathways and association to benigna prostatic hyperplasia. Elsevier. 2011. Volume 82 : 261-271
Hammrsten., Wallner, Lauren P., et al. Hyperglycemia, Hyperinsulinemia, Insulin Resistance, and the Risk of BPH/LUTS Severity and Progression Over Time in Community Dwelling Black Men: The Flint Mens Health Study. Elsevier. 2013. Volume 82: 881-886
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