DOI: https://doi.org/10.14710/jbtr.v3i2.1810

Food Intake and Visceral Fat Deposition are Risk Factors of Incidence and Severity of Non-Alcoholic Fatty Liver Disease

Faculty of Medicine Diponegoro University, Indonesia

Received: 29 Nov 2017; Published: 31 Dec 2017.
Open Access Copyright (c) 2017 Journal of Biomedicine and Translational Research under http://creativecommons.org/licenses/by-sa/4.0/.

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Abstract

Background: Non alcoholic fatty liver disease (NAFLD) is abnormalities of metabolism resulting in fat deposition in the hepatocyte occurred in people who do not consume alcohol. Carbohydrate and fat intake, also visceral fat deposition has been studied as a risk factor of NAFLD, however the results remain elusive.

Objective: To identity the nutritional and clinical risk factors of the incidence and severity of NAFLD.

Methods: This study was done from June to December 2014 in the Dr. Kariadi Hospital Semarang. A case-control group was established comprising 33 patients with NAFLD based on the ultrasonography (USG) criteria (case group) and 34 healthy subject (control group). Carbohydrate and fat intake was assessed by using the food frequency questionnaire (FFQ), visceral fat deposition was measured by body impedance analysis (BIA), and clinical markers were obtained from laboratory data.

Results: Carbohydrate intake, fat intake, and visceral fat deposition were risk factors of the incidence and severity of NAFLD (OR=7.8, CI95% 2.43-25.45; OR=5.9, CI95% 2.0-17.57; OR=50.7, CI95% 6.16-418.09) and (OR=0.9, CI95% 1.06-90.58; OR=14.6, CI95% 1.37-156.88; OR=6.6, CI95% 1.17-37.78). Multivariate regression showed that the most important risk factor of NAFLD for the incidence and severity were hypertriglyceridemia (OR=8.7, CI95% 2.20-34.44) and fat intake (OR=48.4, CI95% 2.78-844.1), respectively.

Conclusion: High carbohydrate intake, fat intake, and high visceral fat deposition are risk factors of the incidence and severity of NAFLD. Hypertriglyceridemia and fat intake are the most important risk factor of NAFLD incidence and severity, respectively.
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Keywords: Non alcoholic fatty liver disease; carbohydrate intake; fat intake; visceral fat,;risk factor

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Language : EN
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  1. Marcos E. Non alcoholic fatty liver disease. Pediatric Annals. 2006; 35(4): p.291-99
  2. Medina J. Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis. Diabetes Care. 2004; 27 : p.2057-66
  3. Bowman J. Systematic Review: the diagnosis and staging of non alcoholic fatty liver disease. Aliment Pharmacol Ther. 2011;33: p.525-40
  4. World Gastroenterology Organisation. Nonalcoholic Fatty Liver Disease and Non Alcoholic Steatohepatitis. World Gastroenterology Organisation Global Guidelines. 2012: p.1-29
  5. Mc Cullough. The Epidemiology and Risk Factor of NASH. In Fatty liver Disease NASH and Related Disorder, Geoffrey C Farrel, eds. Oxford: Blackwell Publishing Ltd.2005: p.23-37
  6. Day CP. NASH: Where are we now and where are we going? Gut. 2002; 50: p.585-88
  7. Sagi S, Goldsmith R, Webb M. Long Term Nutritional Intake and The Risk for Nonalcoholic Fatty Liver Disease : A Population Based study. Journal of Hepatology. 2007;47: p.711-17
  8. Perseghin G. Lipids in The Wrong Place: Visceral Fat and Nonalcoholic Steatohepatitis. Diabetes Care. 2011; 34(2)
  9. Almatsier S. Prinsip Dasar Ilmu Gizi. Jakarta: PT. Gramedia Pustaka Utama. 2001. p. 28-47
  10. Dedeh K, Marfuah P, Saeful I. Sehat dan Bugar Berkat Gizi Seimbang. Jakarta: Kompas Gramedia. 2010.p.101-24
  11. Smith A, wardlaw G. Contemporary Nutrition. United States of America: Mc Graw Hill Companies. 2009.p.120-234
  12. Zivkovic A, Sanyal A. Comparative riview of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. American Journal of Clinical Nutrition. 2007; 3: p.285-96
  13. Muchtadi D, Astawan M, Palupi N. Metabolisme Zat Gizi : Sumber, Fungsi, dan kebutuhan bagi Tubuh Manusia. Jakarta: Pustaka Sinar Harapan; 2000
  14. Gibson R. Principles of Nutritional Assessment. New York: university of Michigan Press. 2005 : p.127-227
  15. Siagian A. Epidemiologi Gizi. Jakarta: Penetbit Erlangga. 2010 : p.11-33
  16. Nyoman D, Bakri B, Fajar I. Penilaian Status Gizi. Jakarta: EGC. 2001: p.21-39
  17. Masuzaki H. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001; 294: p.2166-70
  18. Mathieu P, Poireier P, Pibarot P, Lemieux I. Obesitas Visceral: Hubungan Antara Inflamasi, Hipertensi, dan Penyakit Cardiovaskuler. American Heart Association. 2009; 53(577)
  19. Kyle A, Ursula G, I Bosaeus, al RLe. "Bioelectrical impedance analysis—part I: review of principles and methods". J of Clinical Nutrition. 2004; 23(5): p.1226-43
  20. Bohm A, Heitmann B. The use of bioelectrical impedance analysis for body composition in epidemiological studies. European Journal of Clinical Nutrition. 2013: p.67-79
  21. Westphal B, Later A, Hitze W, Sato B, Kossel T. Accuracy of Bioelectrical Impedance Consumer Devices for Measurement of Body Composition in Comparison to Whole Body Magnetic Resonance Imaging and Dual X-Ray Absorptiometry. Obesity Facts. 2008; 1(6):6
  22. Chasalani N. The Diagnosis and Management of NAFLD : Practice Guideline by the American Association for the Study of Liver Disease, American College of Gastroenterology, and the American Gastroenterological Association Official Journal of the American Association for the Study of Liver Disease. 2005: p. 209-28
  23. Sasdesi L, Purnomo HD. Data Kunjungan Pemeriksaan Ultrasonografi Abdomen Instalasi Radiologi RSUP Dr Kariadi Semarang . 2010
  24. Hasan I, Machmud R. Prevalence and risk factors for nonalcoholic fatty liver in Indonesia. J Gastroenterol Hepatol. 2002; 17(154) : p.67-81
  25. Zimmet P, Matsuzawa Y. The Metabolic Syndrome: A Global Health Problem and A New Definition. J Atheroscl Thromb 2005; 12: p.295-300
  26. Amarapunkar D. Prevalence of non-alcoholic fatty liver disease: population based study. Annals of Hepatology. 2007; 63: p.161-63
  27. Purnomo HD. Peranan Sindrom Metabolik dan Beberapa Biomarker pada Kejadian dan Keparahan Penyakit Perlemakan Hati Bukan Karena Alkohol. Semarang: Universitas Diponegoro. 2013. p.1-156
  28. Weston S, Murphy R. Racial and ethnic distribution of nonalcoholic fatty liver in person with newly diagnosed liver disease. Nutrition in clinical care. 2005; 41: p.372-79
  29. Williams C. Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle Aged population Utilizing Ultrasound and Liver Biopsy : A prospective Study. Gastroenterology. 2011; 140(1) : p.124-31
  30. Marchesini G, Forlani G. Non alcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003; 37(4) : p.917-23
  31. Eric Y, Fransisco D, Myron T. Nonalcoholic Fatty Liver Disease: Pathogenesis, Identification, Progression, and Management. Nutrition in clinical care. 2007;1: p.376-84
  32. Bellentani S, Masutti F. Prevalence of and risk factor for hepatic steatosis Ann Intern Med. 2000;132: p.112-17
  33. Hasan I, Setyohadi B, Alwi I, Simadibrata M, Setiati S. Perlemakan Hati Non Alkoholik. Buku Ajar Ilmu Penyakit Dalam Jakarta: Pusat Penerbit Ilmu Penyakit Dalam FK UI; 2006. p. 464-72
  34. Sakugawa H. Clinical Usefullness of Biochemical Markers of Liver fibrosis in Patient with Nonalcoholic Fatty Liver Disease. World Journal Gastroenterology. 2005;11: p.255-9
  35. Loke K. Consenquences of childhood and adolescent obesity. Journal of Clinical Nutrition 2002;11. p.702-09
  36. Adams L, Lindor K. Nonalcoholic fatty liver disease. CMAJ. 2005;7: p.899-905
  37. Sporea I, Basa E, Corianu M, Popescu A. The value of transabdominal ultrasound for assessment of the severity of liver steatosis as compared to liver biopsy. Cent Eur J Med. 2009; 4(4) : p.490-95
  38. Bisset R. Liver, biliary system, pancreas and spleen. In: Differential Diagnosis In Abdominal Ultrasound. 2 ed. London. 2001. P.203-78
  39. Angulo P. Nonalcoholic fatty liver disease. N England J Med. 2002; 346 : p.1221-31
  40. Sherlock S. Disease of the liver and biliary system. Willey-Blackwell. 2011.p.71-81
  41. Despres J, Lemieux I. Abdominal Obesity and Metabolic Syndrome. Eur J Endocrinol Invest. 2006 (444): p.881-87
  42. Thamer C, Machann J, Stefan N, Haap M, Schifer S. High Visceral Fat Mass and High Liver Fat are Associated with Resistance to Lifestyle Intervention. J Obesity. 2007; 15(2): p.531-38
  43. Nakajima T, Nakashima T, Yamaoka J, Shibuya A, Itoh Y, Yoshikawa T. Age is a Negative, and Visceral fat Accumulation is a Positive, Contributor to Hepatic Steatosis, Regardless of the Fibrosis Progression in Non-alcoholic Fatty Liver Disease. Journal of Gastroenterology and Hepatology Research. 2012;1(11): p.315-19
  44. Jensen D. Is Visceral Fat Involved in the Pathogenesis of the Metabolic Syndrome? J Obesity. 2006;14(1): p.20-24
  45. Naniwadekar A. Nutritional Recomendation for Patien with NAFLD: An Evidence Based Riview. Nutritional Issues in Gastroenterology. 2010; 82 : p.8-16
  46. Sastroasmoro S, Ismael S. Dasar-dasar Penelitian Klinis: Edisi 4. Jakarta: CV.Sagung Seto. 2011 : p.27-108
  47. Cortez P, Baros H, Lopes C, et al. How Different is the Dietary Pattern in Non-Alkoholic steatohepatitis Patients? An International Journal Devoted to Clinical Nutrition and Metabolism. 2006: p.816-23
  48. Hannah E, Bianca A, Seham A, George T, Maha G. A cross sectional study assessing dietary intake and physical activity in Canadian patient with nonalcoholic fatty liver disease vs healthy controls. Journal of The Academy of Nutrition and Dietetics. 2014;114(8): p.1181-94
  49. Lei S, Zhong L, Cai G, Li S, Cheng H, Ming L. The prevalence of nonalcoholic fatty liver disease and its association with lifestyle/dietary habits among university faculty and staff in Chengdu. Biomed Environ Sci. 2012;25(4): p.383-91
  50. Erin M, Mary R. The role of diet and nutrient composition in nonalcoholic fatty liver disease. Journal of The Academy of Nutrition and Dietetics. 2012;112(3): p.401-9
  51. Koppe S. Obesity and the liver: nonalcoholic fatty liver disease. Translational Research. 2014;164(4): p.312-18
  52. Yoon D. Hypoadiponectinemia and insulin Resistance are associated with Nonalcoholic Fatty Liver Disease. Journal Korean Medicine. 2005. p.20-29

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