DOI: https://doi.org/10.14710/jbtr.v3i2.1744

Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism

Clinical Nutrition Jember State Polytechnic, Indonesia

Received: 11 Nov 2017; Published: 31 Dec 2017.
Open Access Copyright (c) 2017 Journal of Biomedicine and Translational Research

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Abstract

Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.  Level of phenylalanine and serotonin were found high in hyperactive children with autism. Level phenylalanine in the brain shows that it is not changed into tyrosine so dopamine can not be form. Serotonin derived from an amino acid tryptophan.

Objective: To understand the association between phenylalanine and tryptophan intake to hyperactivity of  children with autism.

Methods: A survey analytic research with cross sectional approach involving 20 subjects. Phenylalanine and tryptophan intake data was collected by Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ), and hyperactivity disorder of children with autism was measured based on DSM-IV guidelines.

Results: Eight (40%) children had low hyperactivity, 9 (45%) children had moderate hyperactivity, 2 (10%) children had severe hyperactivity, and 1 (5%) child had very severe hyperactivity. Mean phenylalanine intake was 4899.74mg (±1543.42) with maximum and minimum intake respectively 7735.42mg and 1843.88mg. Tryptophan intake was 1153.91mg (±384.99) with maximum and minimum intake respectively 1953.89mg and 367.69mg. There was significant association between phenylalanine intake (p=0,034; r=0,477) and tryptophan intake and hyperactivity (p=0,026; r=0,492).

Conclusion: There is an association between intakes of amino acid phenylalanine and amino acid tryptophan with hyperactivity of autistic children
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Keywords: autism; dopamine; hyperactive; phenylalanine; serotonin; tryptophan

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Section: Original Research Articles
Language : EN
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  3. Faraone, SV. (2011). Epidemiology of Attention Deficit Hyperactivity Disorder. In Tsuang, MT; Tohen, M; Jones, P. Textbook of Psychiatric Epidemiology (3rd ed.). John Wiley & Sons
  4. Singh, I. (2008). Beyond Polemics: Science and Ethics of ADHD. Nature Reviews Neuroscience. 9 (12): 957–964
  5. Kessick R. (2011). Autisme dan Pola Makan yang Penting untuk Anda Ketahui. Jakarta : PT Gramedia Pustaka Utama
  6. Puspaningrum, Christine. (2010). Pusat Terapi Anak Autis di Yogyakarta. Graduate Thesis. Atma Jaya University, Yogyakarta
  7. Wardhani, Fauziah Y, Prabaningrum V, Kirstiana L. (2009). Apa dan Bagaimana Autisme Terapi Medis Alternatif. Jakarta : Fakultas Ekonomi Universitas Indonesia
  8. Brock, S. E., & Knapp, P. K. (1996). Reading comprehension abilities of children with Attention-Deficit/Hyperactivity Disorder. Journal of Attention Disorders. 1: 173-185
  9. Kurniawan, Liong Boy. (2015). Patogenesis, Skrining, Diagnosis, dan Penatalaksanaan Phenylketonuria. Fakultas Kedokteran. Universitas Hasanuddin
  10. Montgomery AJ, McTavish SF, Cowen PJ, Grasby PM. (2014). Reduction of Brain Dopamine Concentration with Dietary Tyrosine Plus Phenylalanine Depletion: an (11C) Radopride PET Study. Am J Psychiatry. 160(10):1887-1889
  11. Musacchio JM. (2013). Enzymes Involved in The Biosynthesis and Degradation of Catecholamines. In Iverson L. Biochemistry of Biogenic Amines. Springer
  12. The National Collaborating Centre for Chronic Conditions, ed. (2006). Symptomatic Pharmacological Therapy in Parkinson's Disease. Parkinson's Disease. London: Royal College of Physicians
  13. Petersen SE, Posner MI. (2012). The Attention System of The Human Brain: 20 Years After. Annu Rev Neurosci. 35: 73-89
  14. Kaluzka-Czaplinska J, Juzwik-Pruska J, Chirumbulo S, Bjorklund G. (2017). Tryptophan Status in Autism Spectrum Disorder and The Influence of Supplementation on Its Level. Metab Brain Dis. 32(5): 1585–1593
  15. Hurt EA, Arnold LE, Lofthouse N. (2011). Dietary and Nutritional Treatments for Attention-Deficit/Hyperactivity Disorder: Current Research Ssupport and Recommendation for Practitioners. Current Psychiatry Report. 13(5): 323-32
  16. Markus CR. (2008). Dietary Amino Acids and Brain Serotonin Function Implication for Stress-Related Afective Changes. Neuromol Med. 10: 247-58

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