DOI: https://doi.org/10.14710/jbtr.v7i1.10051

Prevalence and Risk Factors of ESBL-producing Enterobacteriaceae in The Community

Faculty of Medicine, Universitas Jenderal Soedirman, Indonesia

Received: 1 Jan 2021; Revised: 8 Mar 2021; Accepted: 19 Mar 2021; Available online: 30 Apr 2021; Published: 30 Apr 2021.
Open Access Copyright (c) 2021 Journal of Biomedicine and Translational Research

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Abstract

Background: World Health Organization (WHO) data collection of Escherichia coli resistant to cephalosporin generation III already confirmed in 86 countries. Incredibly high carrier prevalence rates were also widely developed in Thailand, Egypt, and China. The Faculty of Medicine's research team at Jenderal Soedirman University, Purwokerto,  discovered at the beginning of 2018 that Extended Spectrum β-Lactamase (ESBL) E. coli carriers throughout the 2015 class students were 26.8 percent.

Objective: This research investigated the Prevalence and associated factors of ESBL-producing Enterobacteriaceae (EPE) asymptomatic carriers in the community.

Methods: The participant fill a questionnaire, and samples were taken from rectal swabs using Amies transport medium (Labware Charuzu), and then models were analyze using HiCrome ™ ESBL Agar Base (Himedia, India). Analysis of its Prevalence and Resistance Predictors uses IBM SPSS Statistics Version 22.0 for Windows (Armonk, NY: IBM Corp).

Results: The Prevalence of EPE asymptomatic carriers in the community in Purwokerto was 66.7%. In the bivariate analysis, subjects who took antacids in the last eight weeks, history of hospitalization in the previous 12 months, the habit of consuming milk, yogurt, cheese, meat, seafood, and raw vegetables did not show any significant difference. Frequent chicken and freshwater fish consumption tended to be a risk factor for ESBL-producing Enterobacteriaceae with PR 1.462, 95% CI (1.115-1.918); PR 1.666, 95% CI  (0.936-2.966); however, in the multivariate logistic regression analysis, this was not significant.

Conclusion: The Prevalence of EPE asymptomatic carriers in the community in Purwokerto is 66.7%. All variables did not become any significant of ESBL-producing Enterobacteriaceae. However, ESBL remains an emerging antimicrobial resistance.

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PREVALENCE AND RISK FACTORS ASYMPTOMATIC CARRIER EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE (EPE)
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PREVALENCE AND RISK FACTORS ASYMPTOMATIC CARRIER EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE (EPE)
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Keywords: Carrier; Resistance; Risk Factors; Enterobacteriaceae; ESBL
Funding: LPPM, Jenderal Soedirman University

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Section: Original Research Articles
Language : EN
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  8. Sun Q, Tärnberg M, Zhao L, Stalsby Lundborg C, Song Y, Grape M, et al. Varying high levels of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in rural villages in Shandong, China: Implications for global health. PLoS One. 2014;9(11):1–9
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  10. Solé M, Pitart C, Oliveira I, Fàbrega A, Muñoz L, Campo I, et al. Extended-spectrum β-lactamase-producing Escherichia coli fecal carriage in Spanish travelers returning from tropical and subtropical countries. Clin Microbiol Infect. 2014;20(10): O636-9
  11. Pana ZD, Zaoutis T. Treatment of extended-spectrum β-lactamase-producing enterobacteriaceae (ESBLS) infections: What have we learned until now? [version 1; referees: 2 approved]. F1000Research. 2018;7((F1000 Faculty Rev):1347):1–9
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  14. Juneja D, Singh O, Nasa P, Javeri Y, Dang R. Bloodstream esbl infection in critical care unit: Incidence, risk factors, and its impact on outcome. Crit Care Med. 2010;23(2):192–5
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  17. Søraas A, Sundsfjord A, Sandven I, Brunborg C, Jenum PA. Risk Factors for Community-Acquired Urinary Tract Infections Caused by ESBL-Producing Enterobacteriaceae -A Case-Control Study in a Low Prevalence Country. PLoS One. 2013;51(11–12):802–9
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  20. Severin JA, Lestari ES, Kloezen W, Lemmens-den Toom N, Mertaniasih NM, Kuntaman K, et al. Faecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among humans in Java, Indonesia, in 2001-2002. Trop Med Int Heal. 2012;6:150–3
  21. Otter JA, Natale A, Batra R, Tosas Auguet O, Dyakova E, Goldenberg SD, et al. Individual- and community-level risk factors for ESBL Enterobacteriaceae colonization identified by universal admission screening in London. Clin Microbiol Infect. 2019;25(10):1259–65
  22. Shitrit P, Reisfeld S, Paitan Y, Gottesman BS, Katzir M, Paul M, et al. Extended-spectrum beta-lactamase-producing Enterobacteriaceae carriage upon hospital admission: Prevalence and risk factors. J Hosp Infect. 2013;85(3):230–2

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