DOI: https://doi.org/10.14710/genres.v5i2.25718

Pengaruh Pemberian Ekstrak Etanol Daun Bakau Rhizophora mucronata terhadap Pertumbuhan Jamur Candida albicans

Grace Eka Wijayanti  -  Program Studi Kedokteran, Universitas Hang Tuah, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung No. 1, Jagir, Kec. Wonokromo, Kota Surabaya, Jawa Timur 60111, Indonesia
*Dian Ardiana  -  Program Studi Pendidikan Profesi Dokter, Fakultas Kedokteran, Universitas Hang Tuah, Surabaya, Indonesia
Christina Rusli  -  Program Studi Kedokteran, Universitas Hang Tuah, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung No. 1, Jagir, Kec. Wonokromo, Kota Surabaya, Jawa Timur 60111, Indonesia
Received: 12 Jan 2025; Revised: 12 Feb 2025; Accepted: 25 Feb 2025; Available online: 15 Jul 2025; Published: 15 Jul 2025.
Open Access Copyright 2025 Generics: Journal of Research in Pharmacy

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Abstract

Candida albicans merupakan jamur oportunistik yang banyak ditemukan di negara tropis seperti Indonesia dan dapat menyebabkan sariawan, lesi kulit, vulvavaginitis, kandidiuria, serta kandidiasis pada individu dengan gangguan sistem imun. Obat antijamur Candida albicans yang digunakan selama ini memiliki efek samping serta resistensi. Alternatif yang mungkin dapat digunakan adalah daun Rhizophora mucronata yang mengandung alkaloid, flavonoid, steroid, triterpenoid, tanin, dan saponin yang berperan sebagai antijamur. Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode difusi cakram.  Sampel penelitian ini terdiri dari 24 sampel yang terbagi dalam 6 kelompok, yakni kelompok kontrol positif dengan nistatin, kontrol negatif dengan akuades, kelompok ekstrak 25%, 50%, 75%, dan 100%. Candida albicans diinokulasi pada sabouraud dextrose agar. Kemudian agar tersebut diberi ekstrak etanol daun Rhizophora mucronata dan diukur daya hambatnya dengan jangka sorong. Hasil analisis data menunjukkan bahwa ekstrak 50%, 75%, dan 100% dengan konsentrasi 100% memiliki daya hambat paling tinggi, yakni sebesar 9,2225 mm. Pada konsentrasi ekstrak 25% tidak menunjukkan adanya daya hambat. Dengan demikian, ekstrak etanol daun Rhizophora mucronata dapat menghambat pertumbuhan Candida albicans mulai pada konsentrasi 50%. Ekstrak Rhizophora mucronata konsentrasi 100% membentuk zona hambat tertinggi pada pertumbuhan Candida albicans.

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Keywords: jamur oportunistik, antijamur, difusi cakram, kandidiasis

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