DOI: https://doi.org/10.14710/genres.v5i1.24814

Pola Penggunaan Antidiabetes Pada Penderita Diabetes Melitus Yang Terinfeksi Covid-19 Di Rumah Sakit Umum Daerah Dr. M.Yunus Bengkulu

*Nadia Pudiarifanti  -  Pharmacy Study Program Diploma Three Program, Poltekkes Kemenkes Bengkulu, Jln. Indragiri, Bengkulu, Indonesia
Avrila Iqoranny Susilo  -  Pharmacy Study Program Diploma Three Program, Poltekkes Kemenkes Bengkulu, Jln. Indragiri, Bengkulu, Indonesia
Dira Irnameria  -  Pharmacy Study Program Diploma Three Program, Poltekkes Kemenkes Bengkulu, Jln. Indragiri, Bengkulu, Indonesia
Received: 22 Oct 2024; Revised: 7 Nov 2024; Accepted: 17 Dec 2024; Available online: 16 Jan 2025; Published: 15 Jan 2025.
Open Access Copyright 2025 Generics: Journal of Research in Pharmacy

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract

Latar belakang: Virus Severe Acute Respiratory Syndrome (SARS-Cov 2) atau Covid-19 telah menyebar dengan sangat cepat melalui udara yang menyebabkan lebih dari 4,2 juta kasus kematian di dunia. Virus ini memberikan dampak negatif pada beberapa penderita penyakit kronik. Salah satu yang terkena dampaknya adalah penderita diabetes mellitus. Tujuan : penelitian ini adalah untuk mengetahui pola penggunaan antidiabetes dan outcome penderita diabetes yang terinfeksi Covid-19 di Rumah Sakit Umum Daerah M.Yunus Bengkulu. Metode: penelitian ini adalah penelitian ini deskriptif dengan pengambilan data secara total sampling. Data diambil melalui rekam medis pada RSUD M.Yunus Bengkulu rawat inap pada tahun 2021 sebanyak 62 pasien. Hasil : berdasarkan hasil penelitian di dapatkan pola pengobatan antidiabetes pada pasien Covid-19 yaitu 4,48% tidak diberikan antidiabetes, 14,51% diberikan antidiabetes oral, 54,83% diberikan Insulin, dan 25,80% diberikan kombinasi insulin dan antidiabetes oral. Outcome terapi didapatkan 64,5% pasien sembuh dan 35,5% pasien dinyatakan meninggal.  Kesimpulan : Pola terapi antidiabetes paling banyak adalah kombinasi Insulin (Insulin Long acting dan rapid acting) dengan outcome pasien dinyatakan sembuh. Saran : Penelitian lanjut terkait efek samping pasien diabetes yang di diagnosa Covid-19 dan interaksi obat yang digunakan pada pasien.

Fulltext View|Download
Keywords: Insulin, Outcome Therapy, Diabetes Type 2

Article Metrics:

Article Info
Section: Articles
Language : ID
Recent articles
Pengembangan Metode Analisis secara Kromatografi pada Penetapan Kadar Simvastatin dalam Sediaan Obat Pola Penggunaan Antidiabetes Pada Penderita Diabetes Melitus Yang Terinfeksi Covid-19 Di Rumah Sakit Umum Daerah Dr. M.Yunus Bengkulu Pengetahuan dan Perilaku Apoteker Terhadap Penggunaan Antibiotik di Kabupaten Nganjuk Jawa Timur More recent articles
  1. American Diabetes Association. (2022). Standards Of Medical Care In Diabetes — 2022. The Journal Of Clinical And Applied Research And Education, 45(January)
  2. Andriana, A., Pandelaki, K., & Rotty, L. W. A. (2022). Relationship between Hyperglycemia and Outcome of COVID-19 Patients. E-Clinic, 10(28), 214–220
  3. Bornstein, S. R., Rubino, F., Khunti, K., Mingrone, G., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. I., Skyler, J. S., DeVries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Vidal, J., Geloneze, B., Chan, J. C., Ji, L., & Ludwig, B. (2020). Practical recommendations for the management of diabetes in patients with COVID-19. The Lancet Diabetes and Endocrinology, 8(6), 546–550. https://doi.org/10.1016/S2213-8587(20)30152-2
  4. Ciarambino, T., Crispino, P., Leto, G., Mastrolorenzo, E., Para, O., & Giordano, M. (2022). Influence of Gender in Diabetes Mellitus and Its Complication. International Journal of Molecular Sciences, 23(16), 1–13. https://doi.org/10.3390/ijms23168850
  5. Ciardullo, S., Perra, F. Z. S., Cannistraci, E. M. R., & Lattuada, M. L. P. G. G. (2021). Impact of Diabetes on COVID‑19 Related in Hospital Mortality: a Retrospective Study From Northern Italy. Journal of Endocrinological Investigation, 44(4), 843–850. https://doi.org/10.1007/s40618-020-01382-7
  6. IDI, PERDATIN, et al. (2022). Pedoman Tatalaksana Covid-19, Edisi 4 (et al Erlina Burhan (ed.); 4th ed.). PDPI
  7. Karlinsky, A., & Kobak, D. (2021). Tracking Excess Mortality Across Countries During The Covid-19 Pandemic With The World Mortality Dataset. ELife, 10, 1–21. https://doi.org/10.7554/eLife.69336
  8. Kekenusa, J. S., Ratag, B. T., & Wuwungan, G. (2018). Analisis Hubungan Antara Umur dan Riwayat Keluarga Menderita Dm dengan Kejadian Penyakit Dalam Blu Rsup Prof. Dr. R.D Kondou Manado. J Kesmas Univ Sam Ratulangi Manado, 2(1), 1–6
  9. Kow, C. S., Ramachandram, D. S., & Hasan, S. S. (2022). Insulin therapy in patients with COVID-19. Acta Diabetologica, 59(2), 285–286. https://doi.org/10.1007/s00592-021-01810-x
  10. Lalau, J., Al-salameh, A., Hadjadj, S., Goronflot, T., Wiernsperger, N., Pichelin, M., Allix, I., Amadou, C., Dutour, A., Bourron, O., Duriez, T., Gouet, D., Joubert, M., Julier, I., Larger, E., Marchand, L., Quiniou, P., Marre, M., Meyer, L., … Cariou, B. (2021). Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19. Diabetes & Metabolism, 47, 1262–3636. https://doi.org/10.1016/j.diabet.2020.101216
  11. Leutner, M., Kaleta, M., Bellach, L., Kautzky, A., Thurner, S., Klimek, P., & Kautzky-Willer, A. (2021). Insulin as monotherapy and in combination with other glucose-lowering drugs is related to increased risk of diagnosis of pneumonia: A longitudinal assessment over two years. Journal of Personalized Medicine, 11(10), 1–9. https://doi.org/10.3390/jpm11100984
  12. Lim, S., Bae, J. H., Kwon, H. S., & Nauck, M. A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology, 17(1), 11–30. https://doi.org/10.1038/s41574-020-00435-4
  13. Mezil, S. A., & Ahmed, B. (2021). Complication of Diabetes Mellitus. Annals of R.S.C.B, 25(3), 1546–1556
  14. Mueller, A. L., Mcnamara, M. S., & Sinclair, D. A. (2020). Why does COVID-19 disproportionately affect older people ? 12(10), 9959–9981
  15. Nyland, J. E., Raja-khan, N. T., Bettermann, K., Haouzi, P. A., Leslie, D. L., Kraschnewski, J. L., Parent, L. J., & Grigson, P. S. (2021). Diabetes , Drug Treatment , and Mortality in COVID-19 : A Multinational Retrospective Cohort Study. Diabetes Journal, 70(April), 2903–2916
  16. Priya, G., Bajaj, S., Grewal, E., Maisnam, I., Chandrasekharan, S., & Selvan, C. (2020). TOUCH MEDICAL MEDIA Challenges in Women with Diabetes During the COVID-19 Pandemic. Review COVID-19 Journal Publication Date, 16(2), 100–108
  17. Webber, S. (2013). International Diabetes Federation. In Diabetes Research and Clinical Practice (Vol. 102, Issue 2). https://doi.org/10.1016/j.diabres.2013.10.013
  18. World Health Organization. (2021). WHO Coronavirus (COVID-19) Dashboard. In World Health Organization. World Health Organization
  19. Yu, B., Li, C., Sun, Y., Yu, B., Li, C., Sun, Y., & Wang, D. W. (2021). Clinical and Translational Report Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes ll ll Clinical and Translational Report Insulin Treatment Is Associated with Increased Mortality in Patients with COVI. Cell Metabolism, 33, 65–77. https://doi.org/10.1016/j.cmet.2020.11.014
  20. Zangiabadian, M., Nejadghaderi, S. A., & Zahmatkesh, M. M. (2021). The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics : A Systematic Review. Frontiers in Endocrinology, 12, 1–9. https://doi.org/10.3389/fendo.2021.645194
  21. Zhu, M., Liu, X., Liu, W., Lu, Y., Cheng, J., & Chen, Y. (2021). Β Cell Aging and Age-Related Diabetes. Aging, 13(5), 7691–7706. https://doi.org/10.18632/aging.202593

Last update:

No citation recorded.

Last update:

No citation recorded.