DOI: https://doi.org/10.14710/baf.10.1.2025.%25p

Mikroanatomi Ginjal Tikus Putih (Rattus norvegicus L.) Galur Sprague-Dawley Hiperlipidemia setelah Pemberian Ekstrak Etanol Biji Mahoni (Swietenia mahagoni L. Jacq)

Department of Biology, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH., Tembalang, Semarang 50275, Indonesia

Open Access Copyright 2025 Buletin Anatomi dan Fisiologi

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Abstract

The aim of this study was to discover the effect of mahogany seeds (Swietenia mahogani L. Jacq) ethanol extract administration towards the kidney microanatomy of hyperlipidemic white rats (Rattus norvegicus L.) Sprague-Dawley strain. The method of this research was giving the mahogany seeds ethanol extract orally using sonde needle for four weeks. The observed parameters in this research were kidney weight, glomerular diameter, bowman’s capsule thickness, proximal cortical tubule diameter, proximal cortical tubule epithelial cell thickness, distal cortical tubule diameter, and distal cortical tubule epithelial cell thickness. The data was analyzed using ANOVA and Kruskal-Wallis test. The result of this research showed that the administration of mahogany seeds ethanol extract with a concentration of 14mg/200gBB could reduced the glomerular diameter, bowman’s capsule thickness, and distal cortical tubule diameter, concentration of 28mg/200gBB could reduced proximal cortical tubule epithelial cell thickness and distal cortical tubule epithelial cell thickness, and concentration of 56mg/200gBB could reduced kidney weight and proximal cortical tubule diameter. It can be concluded, that mahogany seeds ethanol extract at doses of 14 mg and 28 mg can be said to have the same potential as simvastatin at a dose of 8 mg in suppressing the effects of hypercholesterolemia and maintaining the microanatomy of the kidneys of hyperlipidemic white rats.

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Keywords: biji mahoni (Swietenia mahagoni L. Jacq); hiperlipidemia; mikroanatomi; tikus putih.

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