DOI: https://doi.org/10.14710/baf.8.1.2023.%25p

Immunomostimulant Effectiveness of Ethanolic Extract of Japanese Taro (Colocasia esculenta var. Antiquorum) as an Immune System Enhancer by In-Vivo Test

*Putri ayu Ika Setiyowati orcid  -  Program Studi Biologi, Fakultas Sains Teknologi dan Pendidikan, Universitas Muhammadiyah Lamongan, Indonesia
Dwi Zulianti  -  Program Studi Biologi, Fakultas Sains Teknologi dan Pendidikan, Universitas Muhammadiyah Lamongan, Indonesia
Putri Gita Ayu Savitri  -  Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Lamongan, Indonesia
Chasanah Uswatun  -  Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Lamongan, Indonesia
Filliana Andalucya  -  Program Studi Biologi, Fakultas Sains Teknologi dan Pendidikan, Universitas Muhammadiyah Lamongan, Indonesia
Open Access Copyright 2022 Buletin Anatomi dan Fisiologi

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Abstract

The one of  potential food to increasing immune system is Japanese taro tuber (Colocasia esculenta var. antiquorum). In this study, determine the effect of C. esculenta var. antiquorum with variation dose to increase immune cells like leukocytes, monocytes, and lymphocytes. Extraction method using maceration technique. There were 2 control groups, namely positive control (without injection of bacteria or extract), negative control that injection by Staphylococcus aureus bacteria 0.5 Mc Farland as much as 0.2 mL, the treatment group was divided into 3 groups P1, P2, and P3, treated with sub-cutaneous injection of C. esculenta extract at doses of 50,100, and 200 mg/kg bw for 2 weeks and then left for 1 week, on the 21st day Staphylococcus aureus (S. aureus) was injected. Immune cell parameters were measured on the 7th, 14th, and 21st days. Data analysis was performed using ANOVA. The results showed that the extract of C. esculenta var. antiquorum can increase the number of leukocytes, the percentage of monocytes and the percentage of lymphocytes significantly compared to the control group both before and after being infected by S. aureus bacteria. . The optimal dose as an immunostimulant obtained from this study is 200 mg/kg bw.

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Keywords: Colocasia esculenta var. Antiquorum, immunostimulant, total leukocytes, monocytes, and lymphocytes.

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