DOI: https://doi.org/10.14710/actodont.26204

The Effect of Bay Leaf Extract Gel on Increasing Fibroblasts in Traumatic Ulcers Healing Process

1Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Indonesia

2Department of Pathology Anatomy, Faculty of Medicine, Universitas Diponegoro, Indonesia

Received: 14 Mar 2025; Revised: 22 May 2025; Accepted: 22 May 2025; Available online: 27 May 2025; Published: 1 Jun 2025.
Open Access Copyright 2025 Kurnia Nisa Putri Firawan, Ira Anggar Kusuma, Hermawan Istiadi, Oedijani Santoso
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Abstract
The wound healing process of traumatic injuries in the oral cavity involves four stage: hemostasis, inflammation, proliferation, and remodeling. Fibroblast cells are essential for the wound healing process, appearing on the 3rd day and reaching their peak on the 7th day after injury. This study reveals that bay leaf extract can accelerate wound healing process by mitigating inflammation and enhancing fibroblast cell activity. This research utilized a post-test only control group design. Fifteen male Wistar rats divided in 3 groups equally:  control group and 2 groups were given 5% and 10% of the bay leaf extract gel was applied twice a day until the 5th  day. The results indicated that the group treated with 10% bay leaf extract gel had significantly higher value compared to the control group and the group treated with 5% bay leaf extract gel. In this study, we can learn that bay leaf extract gel can increase of fibroblast cells in the ulcer healing process.
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Section: Original Research
Language : EN
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