DOI: https://doi.org/10.14710/jekk.v9i2.18535

Unveiling the Disease Patterns and Infection Categories in MDRO-Infected Patients: Insights from a Comprehensive Study at Dr. Kariadi Hospital, Semarang

*Saidi Ntambi orcid  -  Kampala International University, Uganda
Dwi Sutiningsih  -  Universitas Diponegoro, Indonesia
Budi Laksono  -  Universitas Diponegoro, Indonesia
Ayub Hussein Maiga  -  St. Peter's University, Kampala, Uganda
Mujahidah Mujahidah  -  Dr. Kariadi Hospital Semarang, Indonesia
Received: 16 May 2024; Published: 31 Aug 2024.

Citation Format:
Abstract

Background: Multi-drug resistant organisms (MDRO) pose a significant challenge to healthcare systems worldwide, leading to increased morbidity, mortality, and healthcare costs. Understanding the disease patterns and infection categories associated with MDRO infections is crucial for effective management and prevention strategies. This study aims to unveil the prevalent diseases and infection categories among MDRO-infected patients at Dr. Kariadi Hospital, Semarang in Indonesia.

Methods: A comprehensive retrospective analysis was conducted on medical records of patients diagnosed with MDRO infections. Clinical characteristics were collected and analyzed. The diseases were classified into broader categories based on their organ system or common medical classification.

Result: The study included 100 MDRO-infected patients and they presented with 81 various medical conditions/diseases. The most common diseases associated with MDRO infections were Covid-19, and Bronchopneumonia. Among the infection categories, gastrointestinal disorders, and Neoplastic Diseases were the predominant categories. The study revealed a high prevalence of MDRO infections in patients with these conditions while as the category of Autoimmune and Rheumatic Diseases accounted for the smallest proportion of cases with only one case.

Conclusion : This comprehensive study provides valuable insights into the disease patterns and infection categories in MDRO-infected patients at Dr. Kariadi Hospital, Semarang. The findings highlight the need for targeted surveillance, infection control measures, and antimicrobial stewardship programs to effectively manage MDRO infections. Understanding the most prevalent diseases and infection categories associated with MDROs can aid in early detection, appropriate treatment, and the development of preventive strategies.

Note: This article has supplementary file(s).

Fulltext View|Download |  Research Instrument
Categorisation of the Diseases
Subject
Type Research Instrument
  Download (20KB)    Indexing metadata
 Research Instrument
Ethical Clearance
Subject
Type Research Instrument
  Download (238KB)    Indexing metadata
Keywords: Multi-drug resistant organisms; disease patterns; infection categories; retrospective analysis

Article Metrics:

Article Info
Section: Articles
Language : EN
Recent articles
Effectivity of Earthworm (Lumbricus rubellus) Extract as Antidiarrhea Caused by Enteropathogenic Escherichia Coli The Influence of Parental Role on Adolescent Sexual Behaviour and HIV/AIDS in KwaZulu-Natal, South Africa. Antibiotic Practices and The Rate of Surgical Site Infection Following Cesarean Section More recent articles
  1. Magiorakos, A.P., Srinivasan, A., and Carey, R.B., et al. 2012 Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect., 18(3) : 268-281
  2. World Health Organization. 2014. Antimicrobial Resistance: Global Report on Surveillance. [Online] Available at: https://www.who.int/antimicrobial-resistance/publications/surveillancereport/en/ [Accessed 28 May 2023]
  3. Laxminarayan, R., Duse, A., and Wattal, C., et al. 2013. Antibiotic resistance-the need for global solutions. The Lancet Infectious Diseases, 13(12) :1057-1098
  4. Centers for Disease Control and Prevention. 2019. Antibiotic resistance threats in the United States, 2019. [Online] Available at: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf [Accessed 28 May 2023]
  5. Tacconelli, E., Carrara, E., and Savoldi, A., et al. 2018. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet Infect. Dis., 18(3) : 318-327
  6. Clinical and Laboratory Standards Institute (CLSI). 2019. Performance standards for antimicrobial susceptibility testing; twenty-ninth edition. CLSI Supplement M100. Wayne, PA, USA: CLSI
  7. European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2021. Breakpoint tables for interpretation of MICs and Zone Diameters, Version 11.0. [Online] Available at: https://www.eucast.org/clinical_breakpoints/ [Accessed 28 May 2023]
  8. Singh, S., and Munoz-Price, L. S. 2014. Risk factors for resistant pathogens in healthcare-associated pneumonia. Seminars in Respiratory and Critical Care Medicine, 35(6), 649-656. doi: 10.1055/s-0034-1395808
  9. Rawson, T. M., Moore, L. S. P., and Zhu, N., et al. 2020. Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis., 71(9) : 2459-2468. doi: 10.1093/cid/ciaa530
  10. Gudiol, C., and Carratalà, J. 2017. Antibiotic resistance in cancer patients. Expert Review of Anti-infective Therapy, 15(9) : 885-895. doi: 10.1080/14787210.2017.1369445
  11. Maki, D. G., Kluger, D. M., and Crnich, C. J. 2006. The risk of bloodstream infection in adults with different intravascular devices: A systematic review of 200 published prospective studies. Mayo Clinic Proceedings, 81(9) : 1159-1171. doi: 10.4065/81.9.1159
  12. Satlin, M. J., Chen, L., Patel, G., Gomez-Simmonds, A., and Weston, G., et al. (2017). Multicenter clinical and molecular epidemiological analysis of bacteremia due to carbapenem-resistant enterobacteriaceae (CRE) in the CRE epicenter of the United States. Antimicrobial Agents and Chemotherapy, 61(4), e02349-16. doi: 10.1128/AAC.02349-16
  13. Fakih, M. G., Holmes, A. H., Reeves, P., & Fitzpatrick, M. A. 2019. Ventilator-associated pneumonia—State of the art. Infection Control and Hospital Epidemiology, 40(1), 8-21. doi: 10.1017/ice.2018.307
  14. Saint, S., Greene, M. T., Kowalski, C. P., Watson, S. R., Hofer, T. P., and Krein, S. L. 2014. Preventing catheter-associated urinary tract infection in the United States: A national comparative study. J. American Med. Assoc. Intern. Med. 174(7) : 1218-1225. doi: 10.1001/jamainternmed.2014.213PMID:24818608
  15. Tschudin-Sutter, S., Kuijper, E. J., Durovic, A., Vos, M. C., and Widmer, A. F. 2018. Multidrug-resistant organisms in hospitals: What is on patients' hands and in their rooms? Clin. Infect. Dis., 67(12) : 1820-1826. doi: 10.1093/cid/ciy413PMID:29860389
  16. Honda, H., and Dubberke, E. R. 2016. The changing epidemiology of Clostridium difficile infection. Current Infect. Dis. Reports, 18(9) : 28. doi: 10.1007/s11908-016-0524-7PMID:27484894
  17. Tumbarello, M., Spanu, T., and Di Bidino, R., et al. 2010. Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy. Antimicrob Agents Chemother. 54(10):4085-4091
  18. Janssen, F.J., van Zon, A., and Hertogs, A.W., et al. 2001. Risk factors for the development of dialysis-requiring acute renal failure after CABG surgery. Eur J Cardiothorac Surg. 20(5):930-936
  19. Tsokos, G.C. 2011. Systemic lupus erythematosus. N Engl J Med. 365(22):2110-2121
  20. Smolen, J.S., Aletaha, D., and McInnes, I.B. 2016. Rheumatoid arthritis. Lancet. 388(10055):2023-2038
  21. Kalil, A.C., Metersky, M.L., and Klompas, M., et al. 2016. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 63(5):e61-e111
  22. Patel, P.K., Gupta, A., Vaughn, V.M., et al. 2019. Clinical effectiveness of monotherapy versus combination therapy for patients hospitalized with acute bacterial skin and skin structure infections. Clin Infect Dis. 69(8):1355-1361
  23. Almasaudi, A.S., Acosta-Ramirez, E., Wise, M., et al. 2018 Characterization of virulence factors, antimicrobial resistance patterns, and sequence types of methicillin-resistant Staphylococcus epidermidis blood culture isolates collected from a Saudi Arabian hospital. Front Microbiol. 9:254
  24. Tumbarello, M., Trecarichi, E.M., Bassetti, M., et al. 2011. Identifying patients harboring extended-spectrum-β-lactamase-producing Enterobacteriaceae on hospital admission: derivation and validation of a scoring system. Antimicrob Agents Chemother. 55(7):3485-3490
  25. Keddis, M.T., Knoll, B.M. 2018. Systemic Lupus Erythematosus and Sjögren Syndrome: What Nephrologists Need to Know. Am J Kidney Dis. 71(6):922-930
  26. Tamma, P.D., Cosgrove, S.E. 2011. Antimicrobial stewardship. Infect Dis Clin North Am. 25(1):245-260

Last update:

No citation recorded.

Last update:

No citation recorded.