DOI: https://doi.org/10.14710/jekk.v6i2.12190

Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner

*I Nengah Raka Swastika  -  Universitas Udayana, Indonesia
Ni Ketut Ristiani  -  Universitas Udayana, Indonesia
Adrian Wiryanata Gorintha  -  Universitas Udayana, Indonesia
Agung Wiwiek Indrayani  -  Universitas Udayana, Indonesia
Received: 29 Aug 2021; Published: 31 Aug 2021.

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Abstract

Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.

Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.

Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.

Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.

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Keywords: Coronary heart disease; Isoflavone aglycone genistein; Lowering LDL; SMEDDS; Soybean seed

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  4. Wang X, Liu S, Yin X, Bellaloui N, McClure M, Mengistu A. 2019. Soybean seed isoflavones respond differentially to phosphorus applications in low and high phosphorus soils. Nutrient Cycling in Agroecosystems. 113(3):217-230
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  6. de Piano A, Masquio D, Dâmaso A. 2019. The Effects of Soy Products and Isoflavones in Metabolic Syndrome and Nonalcoholic Fatty Liver Disease. Bioactive Food as Dietary Interventions for Diabetes. 121-136
  7. Zhang H, Wang Q, Sun C, Zhu Y, Yang Q, Wei Q et al. 2019. Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate. Pharmaceutics. 11(3):107
  8. Wang H, Liu Z, Shao J, Jiang M, Lu X, Lin L, et al. 2020. Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants. Genes & Diseases. 15-32
  9. Linton MRF, Yancey PG, Davies SS, et al. The Role of Lipids and Lipoproteins in Atherosclerosis. [Updated 2019 Jan 3]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK343489/
  10. Sianturi E, Kurniawaty E. 2019. Pengaruh Pektin terhadap Penurunan Risiko Penyakit Jantung Koroner The Effect of Pectin on Reducing the Risk of Coronary Heart Disease. Majority. 8(1):162–167
  11. Cao Y, Xing H, Yang Q, Bao Z, Su B, Yang Y, et al. 2012. Separation of soybean isoflavone aglycone homologues by ionic liquid-based extraction. Journal of Agricultural Food Chemistry. 60(13):3432–40
  13. Dokania S, Joshi AK. 2015. Self-microemulsifying drug delivery system (SMEDDS)-challenges and road ahead. Drug Delivery. 22(6):675–90
  14. Akula S, Gurram AK, Devireddy SR. 2014. Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile. International Scholarly Resarch Notices. 2014:1–11
  15. Wiwiek IA, Martodihardjo S, . S, . J, Ngurah Budiana IGM, . M. 2017. Preparation and In-Vitro characterization of Self-Nano emulsifying system of C- Phenylcalix-[4]-Resorcinaryl Octacinnamate and C-Methylcalix-[4]-Resorcinaryl Octabenzoate as ultraviolet absorbers. Bali Medical Journal. 2017;6(3):569-577
  16. Mandić J, Pirnat V, Luštrik M, German Ilić I, Vrečer F, Gašperlin M, et al. 2020. Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets. Internarional Journal of Pharmaceutics. 583:8
  17. Kumar M, Singh D, Bedi N. 2019. Mefenamic acid-loaded solid SMEDDS: An innovative aspect for dose reduction and improved pharmacodynamic profile. Therapeutic Delivery. 10(1):21–36
  18. Sun C, Gui Y, Hu R, Chen J, Wang B, Guo Y, et al. 2018. Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole. AAPS PharmSciTech. 19(5):2301-2310
  19. Kim DS, Cho JH, Park JH, Kim JS, Song ES, Kwon J, et al. 2019. Self-microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate. International Journal of Nanomedicine. 14:4949-4960
  20. Yoon, G., & Park, S. 2014. Antioxidant action of soy isoflavones on oxidative stress and antioxidant enzyme activities in exercised rats. Nutrition Research and Practice. 8(6):618-624
  21. Suarsana IN, Widyastuti S, Priosoeryanto BP. 2012. Ketersediaan hayati isoflavon dalam plasma dan pengaruhnya terhadap nilai biokimia darah pada tikus hiperglikemia. Jurnal Veteriner. 13(1):86-91
  22. Fawwaz M, Natalisnawati A, dan Baits M. Kadar isoflavon aglikon pada ekstrak susu kedelai dan tempe. Jurnal Teknologi dan Manajemen Agroindustri. 6(3): 152-158
  23. Setyawan, F. 2017. Kajian Tentang efek pemberian nutrisi kedelai (glicine max) terhadap penurunan kadar kolesterol totalpada menopause. Jurnal Pendidik Fakultas Kedokteran Universitas Muhammadiyah Malang. 1(4) : 33-50
  24. Ambrosio R, Ombra MN, Gridelli C, Picariello G, Di Stasio M, Volpe MG. 2016. Isoflavone Extracts Enhance the Effect of Epidermal Growth Factor Receptor Inhibitors in NSCLC Cell Lines. Anticancer Research. 36(11):5827-34
  25. Yulifianti, R., Muzaiyanah, S., & Utomo, J.S. 2018. Kedelai sebagai bahan pangan kaya isoflavon. Buletin Palawijaya. 16(2):84-93

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