DOI: https://doi.org/10.14710/jekk.v8i2.11803

Recent Findings in Malaria Emergence of Piperaquine-Resistant Plasmodium falciparum Genes in Malaria Endemic Areas of Indonesia: a Literature Review

*Ayu Nurdiantika Sari  -  Universitas Indonesia, Indonesia
Tri Yunis Miko Wahyono  -  Universitas Indonesia, Indonesia
Ayleen Alicia Kosasih  -  Universitas Indonesia, Indonesia
Yoshida Aussiana Samosir  -  Universitas Indonesia, Indonesia
Rania Rifdah Taufiq  -  Universitas Indonesia, Indonesia
Inge Sutanto  -  Universitas Indonesia, Indonesia

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Abstract

Background: In recent years, artemisinin and piperaquine (PPQ) resistance in the Greater Mekong Sub-region alarmed Southeast Asian countries, especially those relying on artemisinin- based combinations as antimalarial drugs. This study aims to review the current status of malaria research and examine the frequencies of piperaquine resistance in Plasmodium falciparum isolates originating from malaria-endemic areas in Indonesia.

Methods: We undertook a review to identify empirical data on antimalarial piperaquine-inclusive artemisinin combination therapies (ACT) in Indonesia using studies conducted since 2015. Journal articles were searched using the keywords combination of malaria, piperaquine, Pfcrt, Pfmdr, Pfpm2, and Indonesia. The search was conducted in four databases. Trends in empirical data were summarised in a table and compared with emerging malaria prevalence and conditions in Indonesia.

Results: Our study found that dihydroartemisinin-piperaquine (DHA-PPQ) is still effective in most area. Survey of PPQ resistance in regions using DHA-PPQ as the first-line treatment heavily depends on phenotypic tests of the given drug resistance. Molecular surveys exploring polymorphisms of Pfcrt, Pfmdr1, and Pfpm2 were not found.

Conclusion: This study supports the use of dihydroartemisinin-piperaquine as the first-line antimalarial drug in malaria endemic areas of Indonesia. Further research examining efficacy is required to monitor piperaquine resistance in Indonesia.

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Keywords: piperaquine; Pfmdr; Pfcrt; PfPm2; polymorphism

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  1. Tuteja R. 2007., Malaria - An overview. FEBS J. 274(18):4670–9
  2. World Health Organization. 2016. World malaria report 2016
  3. Elyazar IRF, Gething PW, Patil AP, Rogayah H, Kusriastuti R, Wismarini DM, et al. 2011. Plasmodium falciparum malaria endemicity in indonesia in 2010. PLoS One.6(6)
  4. Poespoprodjo JR, Kenangalem E, Wafom J, Chandrawati F, Puspitasari AM, Ley B, et al. 2018. Therapeutic response to dihydroartemisinin-piperaquine for P. falciparum and P. Vivax nine years after its introduction in southern Papua, Indonesia. Am J Trop Med Hyg. 98(3):677–82
  5. Talundzic E, Chenet SM, Goldman IF, Patel DS, Nelson JA, Plucinski MM, et al. 2015. Genetic analysis and species specific amplification of the artemisinin resistance-associated kelch propeller domain in P. falciparum and P. vivax. PLoS One. 10(8):1–11
  6. Popovici J, Kao S, Eal L, Bin S, Kim S, Ménard D. 2015. Reduced polymorphism in the kelch propeller domain in plasmodium vivax isolates from Cambodia. Antimicrob Agents Chemother. 59(1):730–3
  7. Amato R, Lim P, Miotto O, Amaratunga C, Dek D, Pearson RD, et al. 2017. Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study. Lancet Infect Dis. 17(2):164–73
  8. Pelleau S, Moss EL, Dhingra SK, Volney B, Casteras J, Gabryszewski SJ, et al. 2015. Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. Proc Natl Acad Sci U S A. 112(37):11672–7
  9. Satish K Dhingra, Jennifer L Small-Saunders, Didier Ménard DAF. 2019. Plasmodium falciparum resistance to piperaquine driven by PfCRT Satish. Physiol Behav. 176(1):139–48
  10. Sutanto I, Kosasih A, Elyazar IRF, Simanjuntak DR, Larasati TA, Dahlan MS, et al. 2018. Negligible impact of mass screening and treatment on mesoendemic malaria transmission at west timor in eastern Indonesia: A cluster-randomized trial. Clin Infect Dis. 67(9):1364–72
  11. Green MHL, O’Neill JP, Cole J. 1995. Suggestions concerning the relationship between mutant frequency and mutation rate at the hprt locus in human peripheral T-lymphocytes. Mutat Res Mutagen Relat Subj. 334(3):323–39
  12. Duru V, Khim N, Leang R, Kim S, Domergue A, Kloeung N, et al. 2015. Plasmodium falciparum dihydroartemisinin- piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays : retrospective and prospective investigations. BMC Med [Internet]. 1–11
  13. Arrow KJ, Panosian C GH. 2004. Saving Lives, Buying Time. Saving Lives, Buying Time
  14. Prevention C for DC and Malaria. 2021;1–2. Available from: https://www.cdc.gov/malaria/about/biology/index.html
  15. Amir A, Cheong FW, De Silva JR, Lau YL. 2018. Diagnostic tools in childhood malaria. Parasites and Vectors. 11(1):1–12
  16. Sulistyaningsih E, Loeki EA, Loscher T B-RN. 2008. Plasmodium knowlesi: The fifth human malaria parasite. Clin Infect Dis [Internet]. 46(2):172–3
  17. World Health Organization, Indonesia M of H. 2011. National malaria control programme review: Republic of Indonesia. Handb Falciparum Malaria. 200–200
  18. Dale P, Sipe N, Anto S, Hutajulu B, Ndoen E, Papayungan M, et al. 2005. Malaria in Indonesia: A summary of recent research into its environmental relationships. Southeast Asian J Trop Med Public Health. 36(1):1–13
  19. Kementrian Kesehatan Republik Indonesia. Info Datin. 2016. p. 1–8
  20. Kemenkes RI. 2013. Profile Kesehatan Indonesia. Ministry of Health Indonesia. 107–108 p
  21. Aregawi M, Malm KL, Wahjib M, Kofi O, Allotey NK, Yaw PN, et al. 2017. Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana. Malar J. 16(1)
  22. Hung LQ, De Vries PJ, Giao PT, Nam N V., Binh TQ, Chong MT, et al. 2002. Control of malaria: A successful experience from Viet Nam. Bull World Health Organ. 80(8):660–6
  23. Heng S, Durnez L, Mao S, Siv S, Tho S, Mean V, et al. 2017. Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria. Malar J. 16(1):1–12
  24. Moonen B, Cohen JM, Snow RW, Slutsker L, Drakeley C, Smith DL, et al. 2010. Operational strategies to achieve and maintain malaria elimination. Lancet. 376(9752):1592–603
  25. Cotter C, Sturrock HJW, Hsiang MS, Liu J, Phillips AA, Hwang J, et al. 2013. The changing epidemiology of malaria elimination: New strategies for new challenges. Lancet [Internet]. 382(9895):900–11
  26. Waltmann A, Darcy AW, Harris I, Koepfli C, Lodo J, Vahi V, et al. 2015. High Rates of Asymptomatic, Sub-microscopic Plasmodium vivax Infection and Disappearing Plasmodium falciparum Malaria in an Area of Low Transmission in Solomon Islands. PLoS Negl Trop Dis. 9(5):1–18
  27. White NJ. 2008. Qinghaosu (artemisinin): The price of success. Science (80). 320(5874):330–4
  28. Fairhurst RM, Nayyar GML, Breman JG, Hallett R, Vennerstrom JL, Duong S, et al. 2012. Artemisinin-resistant malaria: Research challenges, opportunities, and public health implications. Am J Trop Med Hyg. 87(2):231–41
  29. Song J, Socheat D, Tan B, Seila S, Xu Y, Ou F, et al. 2011. Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area. Malar J [Internet]. 10(1):231
  30. Leang R, Barrette A, Bouth DM, Menard D, Abdur R, Duong S, et al. 2013. Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated plasmodium falciparum and plasmodium vivax in Cambodia, 2008 to 2010. Antimicrob Agents Chemother. 57(2):818–26
  31. Ocan M, Akena D, Nsobya S, Kamya MR, Senono R, Kinengyere AA, et al. 2019. K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: A systematic review of prevalence and risk factors. Malar J [Internet]. 18(1):1–17
  32. Mbanefo A, Kumar N. 2020 Evaluation of malaria diagnostic methods as a key for successful control and elimination programs. Trop Med Infect Dis. 5(2)
  33. Wilson ML. 2012. Malaria rapid diagnostic tests. Clin Infect Dis. 54(11):1637–41
  34. Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, et al. 2019. African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker. Malar J [Internet]. 18(1):1–11
  35. Gupta H, Galatas B, Chidimatembue A, Huijben S, Cisteró P, Matambisso G, et al. 2020. Effect of mass dihydroartemisinin–piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance. PLoS One. 15(10 October):1–14
  36. Bopp S, Magistrado P, Wong W, Schaffner SF, Mukherjee A, Lim P, et al. 2018. Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum. Nat Commun. 9(1)
  37. Eastman RT, Dharia N V., Winzeler EA, Fidock DA. 2011. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother. 55(8):3908–16
  38. Syafruddin D, Asih PBS, Siregar JE, Tjitra E. 2003. Molecular basis of antimalarial drug resistance in Indonesia. Adv Exp Med Biol. 531:103–15
  39. Huaman MC, Yoshinaga K, Suryanatha A, Suarsana N, Kanbara H. 2004. Short report: Polymorphisms in the chloroquine resistance transporter gene in Plasmodium falciparum isolates from Lombok, Indonesia. Am J Trop Med Hyg. 71(1):40–2
  40. Asih PBS, Dewi RM, Tuti S, Sadikin M, Sumarto W, Sinaga B, et al. 2009. Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite. Am J Trop Med Hyg. 80(6):914–8
  41. Lubis IND, Wijaya H, Lubis M, Lubis CP, Beshir KB. 2020. Plasmodium falciparum Isolates Carrying pfk13 Polymorphisms Harbor the SVMNT Allele of pfcrt in Northwestern Indonesia. 1–11
  42. Suwandi JF, Asmara W, Kusnanto H, Syafruddin D, Supargiyono S. 2019. Efficacy of artemisinin base combination therapy and genetic diversity of plasmodium falciparum from uncomplicated malaria falciparum patient in district of pesawaran, Province of Lampung, Indonesia. Iran J Parasitol. 14(1):143–50
  43. Sikora SA, Poespoprodjo JR, Kenangalem E, Lampah DA, Sugiarto P, Laksono IS, et al. 2019. Intravenous artesunate plus oral dihydroartemisinin-piperaquine or intravenous quinine plus oral quinine for optimum treatment of severe malaria: Lesson learnt from a field hospital in Timika, Papua, Indonesia. Malar J [Internet]. 18(1):1–12
  44. Lubis IND, Wijaya H, Lubis M, Lubis CP, Beshir KB, Staedke SG, et al. 2020. Recurrence of Plasmodium malariae and P. falciparum following treatment of uncomplicated malaria in North Sumatera with dihydroartemisinin-piperaquine or artemether-lumefantrine. In: Open Forum Infectious Diseases. Oxford University Press US. p. ofaa116
  45. Irawati N, Kurniawan B, Suwandi JF, Hasmiwati H, Tjong DH, Kenedi M. 2016. Determination of the falciparum malaria resistance to artemisinin-based combination therapies in Pesawaran, Lampung, Indonesia. Asian J Epidemiol. 10(1):19–25
  46. Ahmed R, Poespoprodjo JR, Syafruddin D, Khairallah C, Pace C, Lukito T, et al. 2019. Efficacy and safety of intermittent preventive treatment and intermittent screening and treatment versus single screening and treatment with dihydroartemisinin–piperaquine for the control of malaria in pregnancy in Indonesia: a cluster-randomised, open-la. Lancet Infect Dis. 19(9):973–87
  47. Meshnick S. 2012. Perspective: Artemisinin-resistant malaria and the wolf. Am J Trop Med Hyg. 87(5):783–4
  48. Simamora D, Fitri LE. 2007. Antimalarial Drug Resistance : Mechanism and the Role of Drug. Kedokt Brawijaya. 23(2):82–92
  49. Klein EY. 2013. Antimalarial drug resistance: a review of the biology and spread. Int J Antimicrob Agents. 41(4):311–7
  50. Murhandarwati EEH, Fuad A, Sulistyawati, Wijayanti MA, Bia MB, Widartono BS, et al. 2015. Change of strategy is required for malaria elimination: A case study in Purworejo District, Central Java Province, Indonesia. Malar J. 14(1):1–14
  51. WHO. 2019. Joint Malaria Programme Review reveals Indonesia is on track for malaria elimination. World Health Organization

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