DOI: https://doi.org/10.14710/hnhs.5.1.2022.125-144

Dampak dan Terapi Non-Farmakologis Periodontitis pada Ibu Hamil; Kajian Literatur

*Lia Arian Apriani  -  Program Studi Kebidanan, Fakultas Kesehatan, Universitas Qamarul Huda Badaruddin Bagu, Indonesia
Lanny Sunarjo  -  Program Studi Magister Terapan Terapis Gigi dan Mulut, Poltekkes Kemenkes Semarang, Indonesia
Melyana Nurul Widyawati  -  Program Studi Magister Terapan Kebidanan, Poltekkes Kemenkes Semarang, Indonesia
Reza Indra Wiguna  -  Program Studi Ilmu Keperawatan, Fakultas Kesehatan, Universitas Qamarul Huda Badaruddin Bagu, Indonesia
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Abstract

Introduction: According to WHO, periodontitis is a disease that affects about 20-50% of the world’s population. Periodontitis in pregnancy is often associated with poor pregnancy outcomes. Nowadays, periodontitis therapy is still giving antibiotics and mouth rinses (chlorhexidine) to reduce the dental plaque. However, these therapies have side effects in the form of antibiotic resistance, allergies and mouth irritation. Therefore, a non-conventional therapeutic that is more effective and safe is needed. Brown seaweed (Sargassum sp) is a promising alternative to its natural potential compounds as periodontitis therapy. The purpose of this study was to analyze the effect of Sargassum sp and the impact of periodontitis on pregnancy.

Methods: This research is a systematic literature review by searching literature through various databases on; PubMed, Cochrane, ScienceDirect, and Google Scholar. The literature was examined in the span of 2015 to 2020. The criteria and keywords were; Sargassum and Periodontitis; Periodontitis and Pregnancy; Periodontal Disease and Pregnancy.

Results: The results of this review found 12 articles that showed that periodontitis is one of the risk factors in pregnancy such as; preeclampsia, LBW, and premature. Furthermore, 9 other articles discussed the antibacterial and anti-inflammatory activity contained in Sargassum sp, which can inhibit the development of P.gingivalis and its virulence factors.

Conclusion: The conclusion is metabolites of Sargassum sp “alginate” were able overcomed periodontitis in pregnancy. Thus, further research is expected to be able to intervene directly and analyze more broadly about the effect of Sargassum sp on periodontitis in pregnancy.
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Keywords: Periodontitis; Pregnancy; Sargassum sp

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  1. Alam, A. S. (2015). Uji Daya Hambat Ekstrak Alga Coklat Spesies Padina sp Terhadap Pertumbuhan Bakteri Porphyromonas gingivalis dan Staphylococcus aureus. Fakultas Kedokteran Gigi. Universitas Hasanuddin Makassar
  2. Apriani, L. A., & Ariyanti, I. (2019). Effectiveness of Brown Seaweed (Sargassum sp.) as Natural Antioxidant for Endothelial Cell Protection in Preeclampsia: a Literature Review. Proceedings of International Conference on Applied Science and Health, 4, 535–544
  3. Bachtiar, S. Y., Tjahjaningsih, W., & Sianita, N. (2012). Effect Of Algae Brown (Sargassum sp.) Extract Against Bacterial Growth Of Escherichia coli. Journal of Marine and Coastal Science, 1(1), 53–60. http://journal.unair.ac.id/download-fullpapers-53-60.pdf
  4. Basha, S., Swamy, H. S., & Mohamed, R. N. (2015). Maternal periodontitis as a possible risk factor for preterm birth and low birth weight - A prospective study. Oral Health and Preventive Dentistry, 13(6), 537–544. https://doi.org/10.3290/j.ohpd.a34053
  5. Caneiro-Queija, L., López-Carral, J., Martin-Lancharro, P., Limeres-Posse, J., Diz-Dios, P., & Blanco-Carrion, J. (2019). Non-surgical treatment of periodontal disease in a pregnant caucasianwomen population: Adverse pregnancy outcomes of a randomized clinical trial. International Journal of Environmental Research and Public Health, 16(19), 1–14. https://doi.org/10.3390/ijerph16193638
  6. Corbella, S., Taschieri, S., Del Fabbro, M., Francetti, L., Weinstein, R., & Ferrazzi, E. (2016). Adverse pregnancy outcomes and periodontitis: A systematic review and meta-analysis exploring potential association. Quintessence International, 47(3), 193–204. https://doi.org/10.3290/j.qi.a34980
  7. da Silva, H. E. C., Stefani, C. M., de Santos Melo, N., de Almeida de Lima, A., Rösing, C. K., Porporatti, A. L., & Canto, G. D. L. (2017). Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: A systematic review with meta-analysis. Systematic Reviews, 6(1), 1–12. https://doi.org/10.1186/s13643-017-0587-3
  8. Dewi, L. (2016). In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2. Medical Archives (Sarajevo, Bosnia and Herzegovina), 70(3), 172–176. https://doi.org/10.5455/medarh.2016.70.172-176
  9. Fitriyah, N., & Widyawati, M. N. (2017). Periodontitis In Pregnancy As Risk Factors Of Preeclampsia : A Literature Review. 2nd International Conference on Applied Science and Health, 273–277
  10. Ganesh, P. R. (2015). Association between periodontitis, prematurity, low birth weight, and CRP levels – A case–control study. International Journal of Dental Science and Research, 2(2–3), 55–63. https://doi.org/10.1016/j.ijdsr.2015.11.005
  11. Ghavami-Lahiji, M., Shafiei, F., Najafi, F., & Erfan, M. (2019). Drug-loaded polymeric films as a promising tool for the treatment of periodontitis. Journal of Drug Delivery Science and Technology, 52(April), 122–129. https://doi.org/10.1016/j.jddst.2019.04.034
  12. Gokmen Karasu, A. F., Kutuk, N., Aydin, S., Adanir, I., Ates, S., & Bademler, N. (2017). Dental health dispositions of pregnant women: A survey from a hospital clinic in Istanbul. Journal of Obstetrics and Gynaecology, 37(6), 752–756. https://doi.org/10.1080/01443615.2017.1306837
  13. Gupta, R., & Acharya, A. K. (2016). Oral Health Status and Treatment Needs among Pregnant Women of Raichur District, India: A Population Based Cross-Sectional Study. Scientifica. https://doi.org/10.1155/2016/9860387
  14. Irma, S., & Sulistijarso, N. (2015). The Effect of Paste of Sukun Leaves Extract (ArtocarpusAltilis) towards Fibroblast cell and Collagen Tissues on Periodontitis Pengaruh Pasta Ekstrak Daun Sukun (ArtocarpusAltilis) terhadap. Jurnal Riset Kesehatan, 4(3), 786–792
  15. Istiayulianingsih, A. (2015). Identifikasi Efek Antiinflamasi Ekstrak Alga Coklat Sargassum Sp Terhadap Mencit. Journal of Chemical Information and Modeling, 53(9), 1689–1699. https://doi.org/10.1017/CBO9781107415324.004
  16. Jeon, H., Yoon, W. J., Ham, Y. M., Yoon, S. A., & Kang, S. C. (2019). Anti-arthritis effect through the anti-inflammatory effect of sargassum muticum extract in collagen-induced arthritic (CIA) Mice. Molecules, 24(2). https://doi.org/10.3390/molecules24020276
  17. Jiang, H., Su, Y., Xiong, X., Harville, E., Wu, H., Jiang, Z., & Qian, X. (2016). Prevalence and risk factors of periodontal disease among pre-conception Chinese women. Reproductive Health, 13(1), 1–8. https://doi.org/10.1186/s12978-016-0256-3
  18. Karimi, M. R., Hamissi, J. H., Naeini, S. R., & Karimi, M. (2015). The Relationship Between Maternal Periodontal Status of and Preterm and Low Birth Weight Infants in Iran: A Case Control Study. Global Journal of Health Science, 8(5), 184–188. https://doi.org/10.5539/gjhs.v8n5p184
  19. Khalighinejad, N., Aminoshariae, A., Kulild, J. C., & Mickel, A. (2017). Apical Periodontitis, a Predictor Variable for Preeclampsia: A Case-control Study. Journal of Endodontics, 43(10), 1611–1614. https://doi.org/10.1016/j.joen.2017.05.021
  20. Kim, M. J., Jeong, S. M., Kang, B. K., Kim, K. B. W. R., & Ahn, D. H. (2019). Anti-inflammatory effects of grasshopper ketone from Sargassum fulvellum ethanol extract on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells. Journal of Microbiology and Biotechnology, 29(5), 820–826. https://doi.org/10.4014/jmb.1901.01027
  21. Konopka, T., & Zakrzewska, A. (2020). Periodontitis and risk for preeclampsia — a systematic review. Ginekologia Polska, 91(3), 158–164. https://doi.org/10.5603/gp.2020.0024
  22. Leal, A. S. M., De Oliveira, A. E. F., Brito, L. M. O., Lopes, F. F., Rodrigues, V. P., Lima, K. F., & De Araújo Martins, I. C. (2015). Association between chronic apical periodontitis and low-birth-weight preterm births. Journal of Endodontics, 41(3), 353–357. https://doi.org/10.1016/j.joen.2014.11.018
  23. Lestari, O. S., Ridwan, R. D., Kusumaningsih, T., & Sidarningsih, S. (2019). The activity of polyclonal IgY derived from Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in inhibiting colonization of Fusobacterium nucleatum and Streptococcus sanguinis. Dental Journal (Majalah Kedokteran Gigi), 81(32), 81–85. https://doi.org/10.20473/j.djmkg.v52.i2.p81
  24. Lohana, M. H., Suragimath, G., Patange, R. P., Varma, S., & Zope, S. A. (2017). A Prospective Cohort Study to Assess and Correlate the Maternal Periodontal Status with Their Pregnancy Outcome. Journal of Obstetrics and Gynecology of India, 67(1), 27–32. https://doi.org/10.1007/s13224-016-0920-0
  25. Martínez-Martínez, R. E., Moreno-Castillo, D. F., Loyola-Rodríguez, J. P., Sánchez-Medrano, A. G., Miguel-Hernández, J. H. S., Olvera-Delgado, J. H., & Domínguez-Pérez, R. A. (2016). Association between periodontitis, periodontopathogens and preterm birth: is it real? Archives of Gynecology and Obstetrics, 294(1), 47–54. https://doi.org/10.1007/s00404-015-3945-1
  26. Moore, J., & Blair, F. (2017). Periodontal health and pregnancy. British Journal of Midwifery, 25(5), 289–292. https://doi.org/10.12968/bjom.2017.25.5.289
  27. Nazir, M. A. (2017). Prevalence of periodontal disease, its association with systemic diseases and prevention. International Journal of Health Sciences. https://doi.org/10.1109/ISIP.2008.139
  28. Oka, S., Okabe, M., Tsubura, S., Mikami, M., & Imai, A. (2019). Properties of fucoidans beneficial to oral healthcare. Odontology, 108(1), 34–42. https://doi.org/10.1007/s10266-019-00437-3
  29. Paju, S., Oittinen, J., Haapala, H., Asikainen, S., Paavonen, J., & Pussinen, P. J. (2017). Porphyromonas gingivalis may interfere with conception in women . Journal of Oral Microbiology, 9(1), 1330644. https://doi.org/10.1080/20002297.2017.1330644
  30. Palanisamy, S., Vinosha, M., Rajasekar, P., Anjali, R., Sathiyaraj, G., Marudhupandi, T., Selvam, S., Prabhu, N. M., & You, S. G. (2019). Antibacterial efficacy of a fucoidan fraction (Fu-F2) extracted from Sargassum polycystum. International Journal of Biological Macromolecules, 125, 485–495. https://doi.org/10.1016/j.ijbiomac.2018.12.070
  31. Pangestuti, I. E., & Amalia, U. (2017). Staphylococcus aureus dan Eschericia coli Phytochemical Compound Screening of Sargassum sp . a nd It ’ s Activity as Antibacterial Against Staphylococcus aureus and Escherichia coli. 12(2), 98–102
  32. Pérez, M. J., Falqué, E., & Domínguez, H. (2016). Antimicrobial action of compounds from marine seaweed. Marine Drugs, 14(3), 1–38. https://doi.org/10.3390/md14030052
  33. Puertas, A., Magan-Fernandez, A., Blanc, V., Revelles, L., O’Valle, F., Pozo, E., León, R., & Mesa, F. (2018). Association of periodontitis with preterm birth and low birth weight: a comprehensive review. Journal of Maternal-Fetal and Neonatal Medicine, 31(5), 597–602. https://doi.org/10.1080/14767058.2017.1293023
  34. Rhomadona, Wurdiana, S., & Hardianti, M. (2017). 2 nd International Conference on Applied Science and Health. 336468502(December 2016), 273–277
  35. Ridwan, R. D. (2019, November 28). Imunoglobulin Y Hambat Bakteri Penyebab Periodontitis - Unair News. http://news.unair.ac.id/2019/11/28/imunoglobulin-y-hambat-bakteri-penyebab-periodontitis/
  36. Riset Kesehatan Dasar (RISKESDAS). (2019). Laporan Nasional Riskesdas 2018. In Badan Penelitian dan Pengembangan Kesehatan Riset. https://doi.org/1 Desember 2013
  37. Roberts, J. L., Khan, S., Emanuel, C., Powell, L. C., Pritchard, M. F., Onsøyen, E., Myrvold, R., Thomas, D. W., & Hill, K. E. (2013). An in vitro study of alginate oligomer therapies on oral biofilms. Journal of Dentistry, 41(10), 892–899. https://doi.org/10.1016/j.jdent.2013.07.011
  38. Rohim, A., Yunianta, & Estiasih, T. (2019). Senyawa-Senyawa Bioaktif Pada Rumput Laut Cokelat Sargassum Sp. : Ulasan Ilmiah. Jurnal Teknologi Pertanian, 20(2), 115–126. https://doi.org/10.21776/ub.jtp.2019.020.02.5
  39. Saraswati, Giriwono, P. E., Iskandriati, D., Tan, C. P., & Andarwulan, N. (2019). Sargassum seaweed as a source of anti-inflammatory substances and the potential insight of the tropical species: A review. Marine Drugs, 17(10), 1–35. https://doi.org/10.3390/md17100590
  40. Sarithakumari, C. H., Renju, G. L., & Kurup, G. M. (2013). Anti-inflammatory and antioxidant potential of alginic acid isolated from the marine algae, Sargassum wightii on adjuvant-induced arthritic rats. Inflammopharmacology. https://doi.org/10.1007/s10787-012-0159-z
  41. Shannon, E., & Abu-Ghannam, N. (2016). Antibacterial derivatives of marine algae: An overview of pharmacological mechanisms and applications. Marine Drugs, 14(4). https://doi.org/10.3390/md14040081
  42. Soroye, M. (2015). Association between periodontal disease and pregnancy outcomes. December 2015
  43. Soroye, M. (2016). Odonto-Stomatologie Tropicale Association between periodontal disease. December 2015
  44. Soucy-Giguère, L., Tétu, A., Gauthier, S., Morand, M., Chandad, F., Giguère, Y., & Bujold, E. (2016). Periodontal Disease and Adverse Pregnancy Outcomes: A Prospective Study in a Low-Risk Population. Journal of Obstetrics and Gynaecology Canada, 38(4), 346–350. https://doi.org/10.1016/j.jogc.2016.02.012
  45. Szekalska, M., Puciłowska, A., Szymańska, E., Ciosek, P., & Winnicka, K. (2016). Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. International Journal of Polymer Science, 2016. https://doi.org/10.1155/2016/7697031
  46. Tedjosasongko, U., Anggraeni, F., Wen, M. L., Kuntari, S., & Puteri, M. M. (2019). Prevalence of caries and periodontal disease among Indonesian pregnant women. Pesquisa Brasileira Em Odontopediatria e Clinica Integrada, 19(1), 1–8. https://doi.org/10.4034/PBOCI.2019.191.90
  47. Wariz, R., Asfa, N. W. r, & Fauzi, A. (2016). The toxicity of brown algae (Sargassum sp) extract to mice (Mus muscullus). Journal of Dentomaxillofacial Science, 1(2), 257. https://doi.org/10.15562/jdmfs.v1i2.7
  48. Yarkac, F. U., Gokturk, O., & Demir, O. (2018). Effect of non-surgical periodontal therapy on the degree of gingival inflammation and stress markers related to pregnancy. 1–8
  49. Zamimi, N., Ab. Halim, N., Md-Muziman-Syah, M. M., Susanti, D., Che Musa, M. F., & Yusof, F. (2020). Antimicrobial effect of seaweeds against oral-borne pathogens: a review. International Journal of Allied Health Sciences, 4, 1049–1056
  50. Zhou, R., Shi, X. Y., Bi, D. C., Fang, W. S., Wei, G. Bin, & Xu, X. (2015). Alginate-derived oligosaccharide inhibits neuroinflammation and promotes microglial phagocytosis of β-amyloid. Marine Drugs. https://doi.org/10.3390/md13095828

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