DOI: https://doi.org/10.14710/genres.v2i1.11252

Kajian Sistematik: Potensi Bunga Telang (Clitoria ternatea) sebagai Antidiabetes

*Yuliana Feni Indriyati  -  Program Studi Farmasi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
Dina Nurlita Dewi  -  Program Studi Farmasi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
Received: 20 Mar 2022; Revised: 16 Apr 2022; Accepted: 4 May 2022; Available online: 16 May 2022; Published: 18 May 2022.
Open Access Copyright 2022 Generics: Journal of Research in Pharmacy

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Abstract

Diabetes mellitus merupakan gangguan metabolisme yang ditandai dengan hilangnya kemampuan homeostasis glukosa karena gangguan sekresi dan kerja insulin. Berbagai database telah melaporkan bahwa bunga telang (Clitoria ternatea) memiliki aktivitas anti-hiperglikemik yang adekuat. Kajian sistematik ini bertujuan untuk mengetahui potensi bunga telang sebagai antidiabetes. Pencarian literatur dilakukan pada 29 Maret 2021 dengan menggunakan database elektronik Pubmed dan Scopus. Literatur yang didapatkan tersebut diseleksi berdasarkan kriteria inklusi dan eksklusi untuk dilakukan ekstraksi data. Ada lima literatur yang memenuhi kriteria inklusi. Berdasarkan hasil analisis secara in vitro, ekstrak air, ekstrak etanol, dan protein ekstrak bunga telang (C. ternatea) terbukti secara efektif menghambat enzim α-amilase, pembentukan AGEs, glikosilasi hemoglobin, dan meningkatkan glukosa uptake. Sementara itu, berdasarkan uji secara in vivo, bunga telang (C. ternatea) terbukti dapat menurunkan kadar glukosa darah dan meningkatkan ekspresi gen PPARɣ, Glut2, Tcf7l2, dan Capn10 serta menurunkan ekspresi gen MCP1. Bunga telang (C. ternatea) memiliki aktivitas sebagai antidiabetes baik secara in vitro maupun in vivo.

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Keywords: Bunga Telang; in Vivo; in Vitro

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  2. Barro, C. and Ribeiro, A. (1983) ‘The study of Clitoria Ternatea L. hay as a forage alternative in tropical countries. Evolution of the chemical composition at four different growth stages’, Journal of the Science of Food and Agriculture, 34(8), pp. 780–782. doi: 10.1002/jsfa.2740340803
  3. Chayaratanasin, P. et al. (2015) ‘Inhibitory effect of Clitoria ternatea flower petal extract on fructose-induced protein glycation and oxidation-dependent damages to albumin in vitro’, BMC Complementary and Alternative Medicine, 15(1). doi: 10.1186/s12906-015-0546-2
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  5. Daisy, P., Santosh, K. and Rajathi, M. (2009) ‘Antihyperglycemic and antihyperlipidemic effects of Clitoria ternatea Linn. in alloxan-induced diabetic rats’, Afr J Microbiol Res, 3(5), pp. 287–291
  6. Feng, J., Yang, X. V. and Wang, R. F. (2011) ‘Bio-assay guided isolation and identification of alfa-glucosidase inhibitors from the leaves of Aquilaria sinensis’, Phytochemistry, 72, pp. 242–247
  7. Iamsaard, S. et al. (2014) ‘Antioxidant activity and protective effect of Clitoria ternatea flower extract on testicular damage induced by ketoconazole in rats’, Journal of Zhejiang University: Science B, 15(6), pp. 548–555. doi: 10.1631/jzus.B1300299
  8. Kamilla, L. et al. (2014) ‘Evaluation of antinociceptive effect of methanolic leaf and root extracts of Clitoria ternatea Linn. in rats.’, Indian journal of pharmacology, 46(5), pp. 515–520. doi: 10.4103/0253-7613.140583
  9. Kavitha, R. and Premalaksmi, V. (2012) ‘Studies on the synergetic effect of Trichosanthes dioica and Clitoria ternatea leaf extract on the streptozotocin- induced diabetic rats’, Int J Res Pharm Biomed Sci, 3(3), pp. 1056–1064
  10. Mahapatra, D. K. and Bharti, S. K. (2019) Medicinal Chemistry with Pharmaceutical Product Development. New Jersey: Apple Academic Press
  11. Maity, N. et al. (2012) ‘Standardized Clitoria ternatea leaf extract as hyaluronidase, elastase and matrix-metalloproteinase-1 inhibitor.’, Indian journal of pharmacology, 44(5), pp. 584–587. doi: 10.4103/0253-7613.100381
  12. Mathew, N. et al. (2009) ‘Larvicidal activity of Saraca indica, Nyctanthes arbor-tristis, and Clitoria ternatea extracts against three mosquito vector species.’, Parasitology research, 104(5), pp. 1017–1025. doi: 10.1007/s00436-008-1284-x
  13. McCowen, K. C. and Smith, R. J. (2013) Diabetes Mellitus: Classification and Chemical Pathology. Third. Edited by B. Caballero. USA: Academic Press
  14. Millati, A., Bahar, Y. and Kusumawinakhyu, T. (2019) ‘Pengaruh sediaan dekok daun zaitun (Olea europaea L.) terhadap kadar glukosa darah pada tikus putih Galur wistar (Rattus norvegicus) galur wistar jantan yang diinduksi aloksan’, Herb-Medicine Journal, 2(2), pp. 20–26. doi: 10.30595/hmj.v2i2.4796
  15. Minelko, M. et al. (2020) ‘Protein extracted from Clitoria ternatea modulates genes related to diabetes in vivo’, International Food Research Journal, 27(4), pp. 610–617
  16. Nithianantham, K. et al. (2011) ‘Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice’, Molecules, 16(12), pp. 10134–10145. doi: 10.3390/molecules161210134
  17. Oguis, G. K. et al. (2019) ‘Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine’, Frontiers in Plant Science, 10(May), pp. 1–23. doi: 10.3389/fpls.2019.00645
  18. Pratap, G. M. J. S. et al. (2012) ‘Evaluation of three medicinal plants for anti-microbial activity.’, Ayu, 33(3), pp. 423–428. doi: 10.4103/0974-8520.108859
  19. Rajamanickam, M., Kalaivanan, P. and Sivagnanam, I. (2015) ‘Evaluation of anti-oxidant and anti-diabetic activity of flower extract of Clitoria ternatea L’, Journal of Applied Pharmaceutical Science, 5(8), pp. 131–138. doi: 10.7324/JAPS.2015.50820
  20. Saito N; Abe, K. H. T. T. C. F. B. P. (1985) ‘Acylated delphinidin glucosides and flavonols from Clitoria ternatea’, Phytochemistry, 24(7), pp. 1583-1586
  21. Sharma, A. K. and Majumder, M. (1990) ‘Some observations on the effect of Clitoria Ternatea Linn on changes in serum sugar level and small intestinal mucosal carbohydrases activities in alloxan diabetes’, Calcutta Med J, 87(11–12), pp. 168–171
  22. Singh, N. K. et al. (2018) ‘Anti-allergy and anti-tussive activity of Clitoria ternatea L. in experimental animals.’, Journal of ethnopharmacology, 224, pp. 15–26. doi: 10.1016/j.jep.2018.05.026
  23. Sivaprabha, J. et al. (2008) ‘A study on the levels of nonenzymic antioxidants in the leaves and flowers of Clitoria ternatea.’, Ancient science of life, 27(4), pp. 28–32
  24. Srinivas, B. K. et al. (2019) ‘Angiosuppressive effects of bio-fabricated silver nanoparticles synthesis using Clitoria ternatea flower: an in vitro and in vivo approach.’, Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 24(7), pp. 1115–1126. doi: 10.1007/s00775-019-01721-x
  25. Suganya, G. et al. (2014) ‘In vitro antidiabetic, antioxidant and anti-inflammatory activity of Clitoria Ternatea L’, International Journal of Pharmacy and Pharmaceutical Sciences, 6(7), pp. 342–347
  26. Venkata Kalyan, B. et al. (2011) ‘Hypoglycaemic activity of seed extract of Clitoria ternatea Linn in streptozotocin-induced diabetic rats’, Pharmacognosy Journal, 3, pp. 45–47
  27. Verma, P. R., Itankar, P. R. and Arora, S. K. (2013) ‘Evaluation of antidiabetic antihyperlipidemic and pancreatic regeneration, potential of aerial parts of Clitoria ternatea’, Revista Brasileira de Farmacognosia, 23(5), pp. 819–829

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