DOI: https://doi.org/10.14710/dimj.v2i1.9546

Correlation between Prolactin Serum with Neutrophil Lymphocyte Ratio (NLR) in Systemic Inflammatory Response Syndrome

*Dwi Retnoningrum orcid  -  Department of Clinical Pathology, Diponegoro University, Indonesia
Meita Hendrianingtyas  -  Department of Clinical Pathology, Diponegoro University, Indonesia
Hermawan Istiadi orcid  -  Department of Anatomical Pathology, Diponegoro University, Indonesia
Ardhea Jaludamascena  -  Department of Clinical Pathology, Dr. Kariadi Hospital, Indonesia
Open Access Copyright (c) 2021 Diponegoro International Medical Journal
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Background: Systemic inflammatory response syndrome (SIRS) is a state of systemic inflammatory activation by various causes. SIRS have a high mortality rate. Prolactin is known to regulate cellular function of immune system.  Neutrophil-lymphocyte ratio (NLR) is simple, cost effective and easy parameter that currently used as inflammation marker.

Objective: The aims of this study is to determine the correlation between prolactin serum with NLR in SIRS patients.

Methods: A cross sectional study was conducted on 50 clinically SIRS patients. Prolactin serum was measured by enzyme linked immunosorbent assay (ELISA) and NLR was calculated manually from absolute neutrophil and lymphocyte count measured by automatic hematology analyzer. Non-parametric Spearman test was used to analyze the correlation between prolactin with NLR.

Results: Median value of serum prolactin level was 11.32 ng/mL (2.76-194.81), whereas the mean value NLR was 16.36 ± 11.58. The correlation between prolactin levels with NLR was r = 0.345, p = 0.014.

Conclusion: There is a weak positive significant correlation between prolactin with neutrophil lymphocyte ratio in SIRS

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Keywords: Neutrophil lymphocyte ratio, Prolactin, SIRS
Funding: This research is supported by the Ministry of Research Technology and Higher Education of Indonesia.

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Section: Original Research Article
Language : EN
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  5. Kanczkowski W, Alexaki V-I, Tran N, Großklaus S, Zacharowski K, Martinez A, et al. Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation. Proc Natl Acad Sci U S A. 2013;110(36):14801-6. https://doi.org/10.1073/pnas.1313945110
  6. Vardas K, Apostolou K, Briassouli E, Goukos D, Psarra K, Botoula E, et al. Early Response Roles for Prolaktin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90 in Severe Sepsis and SIRS. Biomed Res Int. 2014;2014. https://doi.org/10.1155/2014/803561
  7. Oberbeck R, Schmitz D, Wilsenack K, Schu M, Biskup C, Schedlowski M, et al. Prolaktin Modulates Survival and Cellular Immune Functions in Septic Mice 1. J Surg Res. 2003;256:248-56. https://doi.org/10.1016/S0022-4804(03)00214-2
  8. López-meza JE, Lara-zárate L, Ochoa-zarzosa A. Effects of Prolaktin on Innate Immunity of Infectious Diseases. Open Neuroendocrinol J. 2010;3:175-9
  9. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15:4-9. https://doi.org/10.1186/s12902-015-0002-9
  10. Holub M, Beran O, Kaspříková N, Chalupa P. Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections. Cent Eur J Med. 2012;7(2):258-61. https://doi.org/10.2478/s11536-012-0002-3
  11. de Jager CPC, van Wijk PTL, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care. 2010;14(5). https://doi.org/10.1186/cc9309
  12. Kofoed K, Eugen-Olsen J, Petersen J, Larsen K, Andersen O. Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory faktor. Eur J Clin Microbiol Infect Dis. 2008;27(June):375-83. https://doi.org/10.1007/s10096-007-0447-5
  13. Comstedt P, Storgaard M, Lassen AT. The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study. Scand J Trauma Resusc Emerg Med. 2009;17:67. https://doi.org/10.1186/1757-7241-17-67
  14. Lai NA, Kruger P. The predictive ability of a weighted systemic inflammatory response syndrome score for microbiologically confirmed infection in hospitalised patients with suspected sepsis. Crit Care Resusc. 2011;14(3):146-50
  15. Tuyan T, Gazi M, Celik C, Hilmi S. Relationship Between Prolaktin Levels and Neutrophil / Lymphocyte Ratio in Patients With Unexplained Infertility. Med J Aegean Clin. 2015;53(3):140-5
  16. Freeman ME, Kanyicska LA, Lerant A, Nagy G. Prolaktin : Structure , Function , and Regulation of Secretion. 2000;80(4):1523-631. https://doi.org/10.1152/physrev.2000.80.4.1523
  17. Buckley A. Prolaktin , a lymphocyte growth and survival faktor. Lupus. 2001;10:684-90. https://doi.org/10.1191/096120301717164912
  18. Díaz L, Díaz-muñoz M, González L, Lira-albarrán S, Larrea F, Méndez I. Prolaktin in the Immune System. In: Prolaktin. Croatia: Intech; 2013. p. 53-82
  19. Bellis A, Bizzarro A, Pivonello R, Lombardi G, Bellastella A. Prolaktin and Autoimmunity. Pituitary. 2005;8:25-30. https://doi.org/10.1007/s11102-005-5082-5
  20. Sodhi A, Tripathi A. Prolaktin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: Involvement of p-38 MAP kinase, STAT3 and NF-κB. Cytokine. 2008;41(2):162-73. https://doi.org/10.1016/j.cyto.2007.11.007
  21. Matera L, Mori M. Cooperation of pituitary hormone prolaktin with interleukin-2 and interleukin-12 on production of interferon-gamma by natural killer and T cells. [Internet]. Vol. 917, Annals of the New York Academy of Sciences. 2000. p. 505-13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11268378.https://doi.org/10.1111/j.1749-6632.2000.tb05415.x
  22. López-meza JE, Lara-zárate L, Ochoa-zarzosa A. Effects of Prolaktin on Innate Immunity of Infectious Diseases. 2010;175-9
  23. Brand JM, Frohn C, Cziupka K, Brockmann C, Kirchner H, Luhm J. Prolaktin triggers pro-inflammatory immune responses in peripheral immune cells. Eur Cytokine Netw. 2004;15(2):99-104

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