Path Analysis : Public Health Impacts Overview in High Natural Background Radiation Area in Botteng, West Sulawesi of Indonesia

Elanda Fikri; Evan Puspitasari; Amar Sharaf Eldin Khair

doi:10.14710/jphtcr.v5i1.13752

DOI: https://doi.org/10.14710/jphtcr.v5i1.13752

Path Analysis : Public Health Impacts Overview in High Natural Background Radiation Area in Botteng, West Sulawesi of Indonesia

Elanda Fikri¹

, Evan Puspitasari², Amar Sharaf Eldin Khair³

¹Department of Environmental Health, Politeknik Kesehatan Bandung, Cimahi, Indonesia

²Pusat Teknologi Keselamatan Radiasi Dan Metrologi, Jakarta Selatan, Indonesia

³Omdurman Islamic University, Geography Department, Omdurman City, Sudan, Sudan

Received: 28 Feb 2022; Published: 30 Apr 2022.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

BibTex Citation Data :

@article{JPHTCR13752,
    author = {Elanda Fikri and Evan Puspitasari and Amar Sharaf Eldin Khair},
    title = {Path Analysis : Public Health Impacts Overview in High Natural Background Radiation Area in Botteng, West Sulawesi of Indonesia},
    journal = {Journal of Public Health for Tropical and Coastal Region},
  volume = {5},
    number = {1},
    year = {2022},
    keywords = {chromosome aberrations frequency; high natural background radiation; radioecology; public health; radioadaptive response},
    abstract = {  Introduction:  The effect of ionizing radiation exposure in a human being is chromosome aberrations. Botteng has the highest annual radiation exposure rate in Indonesia, which is 6,15 ± 0,81 mSv/year. The people in Botteng were exposed to the low dose radiation, continuously. The purpose of this research is to describe the pathway radiation exposured to inhabitants and the cytogenetic response in the high natural background radiation area.   Methods :  This is a statistical research by cross-sectional. The population is 61 residents, who were chosen randomly from 9 different exposure rate areas.   Path analysis model is used to determine the linearity relationship between internal and external radiation dose to the frequency of chromosomal aberrations in lymphocyte cells.   Results : The results concluded that the external radiation dose rate is 5.49 mSv / year, the internal radiation dose rate is 10.34 mSv / year, the effective dose rate of lymphocyte cells is 1.92 mSv / year, and the mean of chromosome aberrations frequency is 0.00082 of approximately 14,695 metaphase cells observed. The result of the analysis showed that there was no significant correlation between the external dose and the chromosome aberrations frequency. There is a linear relationship between the internal dose and the chromosome aberrations frequency (f count = 6,634 and p-value 0,013 <0,05). The internal and external radiation dose simultaneously affects the effective dose (R2 = 0.901, p-value = 0,000> 0.05), The Internal and external radiation doses affect the chromosome aberrations frequency of peripheral blood lymphocytes only through effective doses (R2 = 0.093, p-value = 0.017> 0.05)  Conclusion : this study provide an effective recommendation for further research as an effort to improve public health in areas with high natural background radiation.},
   issn = {2597-4378},   pages = {20--31}  doi = {10.14710/jphtcr.v5i1.13752},
    url = {https://ejournal2.undip.ac.id/index.php/jphtr/article/view/13752}
}

Citation Format:

Abstract

Introduction: The effect of ionizing radiation exposure in a human being is chromosome aberrations. Botteng has the highest annual radiation exposure rate in Indonesia, which is 6,15 ± 0,81 mSv/year. The people in Botteng were exposed to the low dose radiation, continuously. The purpose of this research is to describe the pathway radiation exposured to inhabitants and the cytogenetic response in the high natural background radiation area.

Methods : This is a statistical research by cross-sectional. The population is 61 residents, who were chosen randomly from 9 different exposure rate areas. Path analysis model is used to determine the linearity relationship between internal and external radiation dose to the frequency of chromosomal aberrations in lymphocyte cells.

Results: The results concluded that the external radiation dose rate is 5.49 mSv / year, the internal radiation dose rate is 10.34 mSv / year, the effective dose rate of lymphocyte cells is 1.92 mSv / year, and the mean of chromosome aberrations frequency is 0.00082 of approximately 14,695 metaphase cells observed. The result of the analysis showed that there was no significant correlation between the external dose and the chromosome aberrations frequency. There is a linear relationship between the internal dose and the chromosome aberrations frequency (f count = 6,634 and p-value 0,013 <0,05). The internal and external radiation dose simultaneously affects the effective dose (R2 = 0.901, p-value = 0,000> 0.05), The Internal and external radiation doses affect the chromosome aberrations frequency of peripheral blood lymphocytes only through effective doses (R2 = 0.093, p-value = 0.017> 0.05)

Conclusion: this study provide an effective recommendation for further research as an effort to improve public health in areas with high natural background radiation.

Fulltext View|Download

Keywords: chromosome aberrations frequency; high natural background radiation; radioecology; public health; radioadaptive response

Funding: The research was supported by General Project of Center for Technology of Radiation Safety, Nuclear Energy Agency of Indonesia

Article Metrics:

Article Info

Section: Articles

Language : EN

In Vol 5, No 1 (2022): Journal of Public Health for Tropical and Coastal Region

Recent articles

Readiness of Water Sanitation and Hygiene Facilities (WASH) as an Effort to Prevent COVID-19 Transmission in Elementary Schools at Ngaliyan District, Semarang City Path Analysis : Public Health Impacts Overview in High Natural Background Radiation Area in Botteng, West Sulawesi of Indonesia Youth Empowerment in the Integration Program of Stunting Prevalence Reduction in East Java during Covid-19 Pandemic: A Document Review More recent articles

United Nations Scientific Committee on the Effects of Atomic Radiation. Scientific Report: summary of low-dose radiation effects on health. United Nations Publication. 2011. 4–14 p. Available at http://www.unscear.org/docs/publications/2010/UNSCEAR_2010_Report.pdf
Ramadhani D, Syaifudin M, Nurhayati S, Tetriana D, Rahardjo T, Mailana W, et al. Assessment of DNA damage in lymphocytes of Mamuju (a high background radiation area) inhabitants using alkaline single cell gel electrophoresis. Int J Low Radiat. 2017;10(4):314
Setiawan A, Pudjadi E, Laju P, Radiasi D, Di G, Pulau W, et al. Pemetaan Laju Dosis Radiasi Gamma Di Wilayah Pulau Bangka. 2013;205–11
Hasan Basri IK, Yusuf D, Rahardjo T, Nurhayati S, Tetriana D, Ramadhani D, et al. Study of γ-H2AX as DNA double strand break biomarker in resident living in high natural radiation area of Mamuju, West Sulawesi. J Environ Radioact. 2017;171:212–6
Udiyani PM, Setiawan MB, Subekti M, Kuntjoro S, Pane JS, Hastuti EP, et al. Assessment of dose consequences based on postulated BDBA (beyond design basic accident) A-30MWt RSG-GAS after 30-year operation. Prog Nucl Energy. 2021;140:103927. doi: 10.1016/j.pnucene.2021.103927
George K, Willingham V, Wu H, Gridley D, Nelson G, Cucinotta FA. Chromosome aberrations in human lymphocytes induced by 250 MeV protons: effects of dose, dose rate and shielding. Adv Sp Res. 2002 Jan 1;30(4):891–9
Harty Krieg R, Hickey EE, Weber JR, Masnik MT. Nuclear Power Plants, Decommissioning of. Encycl Energy. 2004;409–20. doi: 10.1016/B0-12-176480-X/00415-0
Amiro BD. Environmental Radioactivity. Encycl Phys Sci Technol. 2003;583–99. doi: 10.1016/B0-12-227410-5/00228-3
Siegel MD, Bryan CR. Environmental Geochemistry of Radioactive Contamination. Treatise on Geochemistry. 2003 Dec 4;9–9:205–62
Holly A. Swartz, Jessica C. Levenson and EFU. 乳鼠心肌提取 HHS Public Access. Physiol Behav. 2012;43(2):145–53
Kravtsov V, Livanova A, Belyakov O, Fedortseva R. The frequency of lymphocytes containing dumbbell-shaped nuclei depends on ionizing radiation dose and correlates with appearance of chromosomal aberrations. Genome Integr. 2018;9(1):1–7
Mothersill C, Seymour C. Low dose radiation mechanisms: The certainty of uncertainty. Mutat Res Toxicol Environ Mutagen. 2022 Apr 1;876–877:503451
Alatas Z. Paradigma Bard Efek Radiasi Dosis Rendah. Bul Al. 2011;13(2):242258
Ramachandran EN, Karuppasamy C V., Kumar VA, Soren DC, Kumar PRV, Koya PKM, et al. Radio-adaptive response in peripheral blood lymphocytes of individuals residing in high-level natural radiation areas of Kerala in the southwest coast of India. Mutagenesis. 2017;32(2):267–73
Marín A, Martín M, Liñán O, Alvarenga F, López M, Fernández L, et al. Bystander effects and radiotherapy. Reports Pract Oncol Radiother. 2015;20(1):12–21
Lehnert BE, Goodwin EH. Extracellular factor(s) following exposure to α particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 1997;57(11):2164–71
Pillon S. Actinide-Bearing Fuels and Transmutation Targets. Compr Nucl Mater. 2012;3:109–41
Burakov BE. Lava-Like Materials Formed and Solidified During Chernobyl Accident. Compr Nucl Mater Second Ed. 2020 Jul 22;525–39
Liu J, Zhou J, Wu M, Hu CF, Yang J, Li D, et al. Low-dose total body irradiation can enhance systemic immune related response induced by hypofractionated radiation. Front Immunol. 2019;10(FEB):1–16
Hekim N, Cetin Z, Nikitaki Z, Cort A, Saygili EI. Radiation triggering immune response and inflammation. Cancer Lett. 2015 Nov 28;368(2):156–63
Georgakilas AG, Pavlopoulou A, Louka M, Nikitaki Z, Vorgias CE, Bagos PG, et al. Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches. Cancer Lett. 2015 Nov 28;368(2):164–72
Schöllnberger H, Stewart RD, Mitchel REJ, Hofmann W. An Examination of Radiation Hormesis Mechanisms Using a Multistage Carcinogenesis Model. Nonlinearity Biol Toxicol Med. 2004;2(4):154014204909002
Scott BR, Belinsky SA, Leng S, Lin Y, Wilder JA, Damiani LA. Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: An evolutionary gift for mounting adaptive protection against lung cancer. Dose-Response. 2009;7(2):104–31
Liu SZ. Biological effects of low level exposures to ionizing radiation: Theory and practice. Hum Exp Toxicol. 2010;29(4):275–81
Cui J, Yang G, Pan Z, Zhao Y, Liang X, Li W, et al. Hormetic response to low-dose radiation: Focus on the immune system and its clinical implications. Int J Mol Sci. 2017;18(2)
Lumniczky K, Impens N, Armengol G, Candéias S, Georgakilas AG, Hornhardt S, et al. Low dose ionizing radiation effects on the immune system. Environ Int. 2021;149(June 2020)
Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E. Environmental and Health Impacts of Air Pollution: A Review. Front Public Heal. 2020;8(February):1–13
Borzoueisileh S, Monfared AS, Abediankenari S, Mostafazadeh A, Khosravifarsani M. The effects of residence duration in high background radiation areas on immune surveillance. J Nat Sci Biol Med. 2013 Jan;4(1):218—222. doi: 10.4103/0976-9668.107295
Venkat S, Apte SK, Chaubey RC, Chauhan PS. Radioadaptive response in human lymphocytes in vitro. J Environ Pathol Toxicol Oncol Off organ Int Soc Environ Toxicol Cancer. 2001;20(3):165–75
Bannister LA, Serran ML, Mantha RR. Low-Dose Gamma Radiation Does Not Induce an Adaptive Response for Micronucleus Induction in Mouse Splenocytes. Radiat Res. 2015 Nov;184(5):533–44
Komova O, Krasavin E, Nasonova E, Mel’nikova L, Shmakova N, Cunha M, et al. Relationship between radioadaptive response and individual radiosensitivity to low doses of gamma radiation: an extended study of chromosome damage in blood lymphocytes of three donors. Int J Radiat Biol. 2018 Jan;94(1):54–61

Last update:

No citation recorded.

Last update:

No citation recorded.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Starting in 2021, the author(s) whose article is published in the JPHTCR journal attain the copyright for their article. By submitting the manuscript to JPHTCR, the author(s) agree with this policy. No special document approval is required.

The author(s) guarantee that their article is original, written by the mentioned author(s), has never been published before, does not contain statements that violate the law, does not violate the rights of others, is subject to copyright that is held exclusively by the author(s), and is free from the rights of third parties, and that the necessary written permission to quote from other sources has been obtained by the author(s).

The author(s) retain all rights to the published work, such as (but not limited to) the following rights:

Copyright and other proprietary rights related to articles, such as patents,
The right to use the substance of the article in its own future works, including lectures and books,
The right to reproduce articles for its own purposes,
The right to archive articles yourself (please read our deposit policy), and
The right to enter into separate additional contractual arrangements for the non-exclusive distribution of published versions of articles (for example, posting them to institutional repositories or publishing them in a book), with acknowledgment of its initial publication in this journal (Journal of Public Health for Tropical and Coastal Region).
If the article was prepared jointly by more than one author, each author submitting the manuscript warrants that they have been given permission by all co-authors to agree to copyright and license notices (agreements) on their behalf, and agree to notify the co-authors of the terms of this policy. JPHTCR will not be held responsible for anything that may arise because of the writer's internal dispute. JPHTCR will only communicate with correspondence authors.

Authors should also understand that once published, their articles (and any additional files, including data sets, and analysis/computation data) will become publicly available. The license of published articles (and additional data) will be governed by the Creative Commons Attribution license as currently featured on the Creative Commons Attribution-ShareAlike 4.0 International License. JPHTCR allows users to copy, distribute, display and perform work under license. Users need to attribute the author(s) and JPHTCR to distribute works in journals and other publication media. Unless otherwise stated, the author(s) is a public entity as soon as the article is published.