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Hubungan Tingkat Pengetahuan dan Tingkat Kepatuhan Minum Obat dengan Tingkat Kekambuhan Lupus Eritematosus Sistemik

*Dinda Sinta Rahayu  -  Universitas Diponegoro, Indonesia
Ari Udiyono  -  Universitas Diponegoro, Indonesia
Lintang Dian Saraswati  -  Universitas Diponegoro, Indonesia

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Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with varied manifestations and characterized by recurring flares. Lack of disease knowledge and non-compliance with drug therapy are an important cause of not achieving treatment targets and worsening lupus symptoms.

Methods: This research is a descriptive study with a cross-sectional approach. The research method is quantitative. The sample in this study were 136 patients who came to examine themselves at Central-General Hospital in Semarang City. The sampling technique used in this study was total sampling. This study used a questionnaire to determine the variables studied.

Result: The results of this study indicate a significant correlation between the level of knowledge (r=-0,332; p < 0,05) and level of drug adherence (r=-0,644; p < 0,05) to the level of systemic lupus erythematosus flares

Conclusion : Based on the results, there is a correlation between knowledge and drug adherence to the level of systemic lupus erythematosus flares. The recommendation given is an integrated approach between patients and health care providers to improve patients understanding of systemic lupus erythematosus flares. Beside of that, specific attention should be paid to integrate the service provision system into the collaborative approach of the patients and his/her family in order to promote the level of drug adherence. 

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Keywords: Systemic Lupus Erythematosus; Flares; Knowledge; Adherence

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  1. Hikmah Z, Prihaningtyas RA. 2018. Bersahabat dengan lupus. Jakarta: PT Elex Media Komputindo.
  2. Kamphuis S, Silverman ED. 2010. Prevalence and burden of pediatric-onset systemic lupus erythematosus. Nat Rev Rheumatol [Internet]. 6(9):538–46. Available from:
  3. Abbas AK, Aster JC, Kumay V. 2014. Buku ajar patologi robbins. 9th ed. Nasar IM, Cornain S, editors. Singapura: Elsevier saunders;
  4. Silva CA, Avcin T, Brunner HI. 2012. Taxonomy for systemic lupus erythematosus with onset before adulthood. Arthritis Care Res (Hoboken). 64(12):1787–93
  5. Farkhati MY, Hapsara S, Satria CD. 2012. Antibodi anti DS-DNA sebagai faktor prognosis mortalitas pada lupus eritematosus sistemik. Sari Pediatr. 14(2):90–6
  6. Kementrian Kesehatan Republik Indonesia. 2017. Situasi lupus di Indonesia. Jakarta
  7. Pons-Estel GJ, Alarcon GS, Scofield L, Reinlib L, Cooper GS. 2010. Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum [Internet]. 39(4):257. Available from:
  8. Danchenko N, Satia JA, Anthony M. 2006. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Sage.15(5):308–18
  9. Wallace DJ. 2007. The lupus book. 1st ed. Wiratama C, editor. Bandung: B-First;
  10. Lipsky P. 2001. Systemic lupus erythematosus: An autoimmune disease of B cell hyperactivity. Nature Immunology [Internet]. Sep;764–6. Available from:
  11. Zharkova O, Celhar T, Cravens PD, Satterthwaite AB, Fairhust AM, Davis LS. 2017. Pathways leading to an immunological disease: systemic lupus erythematosus. Br Soc Rheumatol [Internet]. 56(1):55–66. Available from:
  12. Adamichou C, Bertsias G. 2017. Flares in systemic lupus erythematosus: diagnosis, risk factors and preventive strategies. Mediterr J Rheumatol [Internet]. 28(1):4–12. Available from:
  13. Conti F, Ceccarelli F, Perricone C, Miranda F, Truglia S, Massaro L, et al. 2012. Flare, persistently active disease, and serogically active clinically quiescent disease in systemic lupus eryhthematosus: a 2-year follow-up study. PLoS One [Internet]. 7(9):1–6. Available from:
  14. Julian LJ, Yelin E, Yazdany J, Panopalis P, Trupin L, Criswell LA, et al. 2009. Depression, medication adherence, and service utilization in systemic lupus erythematosus. Arthritis Rheum.; 1(2):240–6
  15. Sari NPWP. 2015;. Faktor pencetus gejala dan perilaku pencegahan sistemic lupus erythematosus. J Ners. 11(2):213–9
  16. Bin Haikel KA, Al Tulaihi B. 2018. Awareness of systemic lupus erythematosus among primary health care patients in Riyadh, Saudi Arabia. Maced J Med Sci [Internet]. 6(12):2386–92. Available from:
  17. Notoatmodjo S. 2012. Promosi kesehatan dan perilaku kesehatan. Jakarta: Rineka Cipta;
  18. Ukwaja KN, Alobu I, Nweke CO, Onyenwe EC. 2013. Healthcare-seeking behavior, treatment delays and its determinants among pulmonary tuberculosis patients in rural Nigeria: a cross-sectional study. BMC Health Serv Res. 13(25):1–9
  19. Zhang L, Luan W, Geng S, Ye S, Wang X, Qian L, et al. 2019. Lack of patient education is risk factor of disease flare in patients with systemic lupus erythematosus in China. BMC Health Serv Res. 19(1):1–8
  20. Niven N. 2000. Psikologi kesehatan edisi kedua. Pengantar untuk perawat dan profesional kesehatan lain. 2nd ed. Jakarta: EGC Penerbit Buku Kedokteran;
  21. Smet B. 1994. Psikologi Kesehatan. Jakarta: PT. Gramedia
  22. Koneru S, Kocharla L, Higgins GC, Ware A, Passo MH, Farhey YD, et al. 2008. Adherence to medications in systemic lupus erythematosus. J Clin Rheumatol.;14(4):195–201

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