Faktor Risiko Kejadian Nefropati Diabetika pada Wanita

*Sri Wahyuningsih -  Kantor Kesehatan Pelabuhan Kelas II Semarang, Indonesia
Heri Nugroho -  Universitas Diponegoro, Indonesia
Suhartono Suhartono -  Universitas Diponegoro, Indonesia
Suharyo Hadisaputro -  Universitas Diponegoro, Indonesia
Mateus Sakundarno Adi -  Universitas Diponegoro, Indonesia
Published: 3 Mar 2019.
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Abstract

Background: Diabetic nephropathy was the most frequent complication in diabetics. The prevalence in women at South East Asia country was higher than men, that different than in Europe, American and African. It's a controversial thing. There was no research about the risk factors for diabetic nephropathy in women in Indonesia.

Methods: The purpose of this study was to determine the risk factors for stage 3-5 diabetic nephropathy in women. This research used case-control study design. The cases were women with stage 3-5 diabetic nephropathy. Sampling by consecutive sampling technique by comparing the age of the case. Data were analyzed statistically by univariate, bivariate and multivariate using multiple logistic regression analysis.

Results: The results of the analysis showed that the risk factors for stage 3-5 diabetic nephropathy were hyperuricemia (OR:9.6; 95%CI:1.870-45.799), lack of physical activity (OR:9.5; 95%CI:1.693-53,287), blood sugar level ≥126 mg/dl (OR:14.7; 95% CI:1.487-145.846), history of oral contraceptive use (OR:7.3; 95%CI:1.254-42.716) and history of obesity (OR:8.9; 95%CI:1.195-65.766).

Conclusion: It is recommended for diabetics people to control uric acid levels, fasting blood glucose, body weight and does enough physical activity. For oral contraceptives users it is recommended to consult with a doctor during consumption.

Keywords
Diabetic Nephropathy, Risk Factor, Women

Article Metrics:

  1. PERNEFRI. 2016. 9th Report Of Indonesian Renal Registry.
  2. Lim AK. 2014. Diabetic Nephropathy –Complications and Treatment. International Journal of Nephrology and Renovascular Disease;7:2.
  3. Ismaili FA, Salmi IA, Maimani YA, Metry AM, Marhoobi HA, Hola A, et al. 2017. Epidemiological Transition of End-Stage Kidney Disease in Oman. Kidney International Reports;2.pp.27-35.
  4. Ahmad J. 2015. Management of Diabetic Nephropathy: Recent Pro-gress and Future Perspective. Diabetes & Metabolic Syndrome: Clinical Research & Reviews;9.pp.343-358.
  5. Salinero-Fort MÁ, Andrés-Rebollo FJS, Burgos-Lunar Cd, Abánades-Herranz JC, Carrillo-de-Santa-Pau E, Chico-Moraleja RM, et al. 2016. Cardiovascular and All-Cause Mortality in Patients with Type 2 Diabetes Mellitus in the MADIABETES Cohort Study: Association with chronic kidney disease. Journal of Diabetes and Its Complications. 2016;30(227-236).
  6. Ang YG, Heng BH, Saxena N, Liew STA, Chong P-N. 2016. Annual All-Cause Mortality Rate for Patient with Diabetic Kidney Disease in Singapore. Journal of Clinical & Translational Endocrinology;4.pp.1-6.
  7. Ariyanto. 2016. Beberapa faktor Risiko Penyakit Ginjal Kronik (PGK) stadium V pada Kelompok Usia di Bawah 50 Tahun. Universitas Diponegoro Thesis unpublished.
  8. Thomas S, Karalliedde J. 2014. Other Complication of Diabetes: Diabetic Nephropathy. Medicine;43(1).pp.20–25.
  9. Atkins RC, Zimmet P. 2010. Diabetic Kidney Disease: Act Now or Pay Later. JNEPHROL;23(01).pp.1-4.
  10. Al-Rubeaan K, Youssef AM, Subhani SN, Ahmad NA, Al-Sharqawi AH, Al-Mutlaq HM, et al. 2014. Diabetic Nephropathy and Its Risk Factors in a Society with a Type 2 Diabetes Epidemic: A Saudi National Diabetes Registry-Based Study. PLOS ONE;9(2):e88956.
  11. Goñi MJ, Mozas D, Forga L, Anda E, Ibañez B, Cambra K. 2016. Incidence and Risk Factors Involved in the Development of Nephropathy in Patients with Type 1 Diabetes Mellitus: Follow Up Since Onset. Can J Diabetes;40.pp.258-263.
  12. Abougalambou SSI, Abougalambou AS, Barghash SS. 2016. A Study Evaluating the Prevalence of Nephropathy among Type 2 Diabetes Patients Attending a Teaching Hospital in Malaysia. J Clin Nephrol Ren Care;2(1)
  13. Loh PT, Toh MPHS, Molina JA, Vathsala A. 2015. Ethnic Disparity in Prevalence of Diabetic Kidney Dise-ase in an Asian Primary Healthcare Cluster. Nephrology;20.pp.216-223.
  14. Soegondo S, Prodjosudjadi W, Setiawati A. 2009. Prevalence and Risk Factors for Microalbuminuria in A Cross-Sectional Study of Type-2 Diabetic Patients in Indonesia : A Subset Of DEMAND Study. Med J Indones;18.pp.124-130.
  15. Pyrama R, Kansaraa A, Banerjia MA, Loney-Hutchinson L. 2012. Chronic Kidney Disease and Diabetes. Maturitas;71.pp.94-103.
  16. John S. 2016. Complication in Diabetic Nephropathy. Diabetes & Metabolic Syndrome: Clinical Research & Reviews;10.pp.247-249.
  17. Zheng W, Chen L. 2011. Factor Analysis of Diabetic Nephropathy in Chinese Patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews;5.pp.130-136.
  18. Lim S, Chellumuthi C, Crook N, Rush E, Simmons D. 2008. Low Prevalence of retinopathy, but High Prevalence of Nephropathy Among Maori With Newly Diagnosed Diabetes—Te Wai o Rona: Diabetes Prevention Strategy. Diabetes Research and Clinical Practice;80.pp.271-274.
  19. Ravid M, Brosh D, Ravid-Safran D, Levy Z, Rachmani R. 1998. Main Risk Factors for Nephropathy in Type 2 Diabetes Mellitus Are Plasma Cholesterol Levels, Mean Blood Pressure, and Hyperglycemia. Arch Intern Med;158.pp.998-1004.
  20. Antus B, Hamar P, Kokeny G, Szollosi Z, Mucsi I, Nemes Z, et al. 2003. Estradiol is Nephroprotective in The Rat Remnant Kidney. Nephrology Dialysis Transplantation;18.pp.54-61.
  21. The PC, Kolibu FK, Rattu AJM. 2017. Hubungan Antara Penggunaan Pil Keluarga Berencana dengan Hiper-tensi pada Pasangan Usia Subur di Desa Sangaji Nyeku Kecamatan Tabaru Kabupaten Halmahera Barat. PHARMACONJurnal Ilmiah Farmasi – UNSRAT;6.
  22. Park H, Kim K. 2013. Associations Betwee Oral Contraceptive Use and Risks of Hypertension And Prehypertension in A Cross-Sectional Study of Korean Women. BMC Women's Health;13.
  23. Pusdatin-Kemenkes. 2014. Situasi dan Analisis Keluarga Berencana. INFO-DATIN.
  24. Parveen K, Siddiqui WA, Kausara MA, Kuddusa M, Shahida SMA, Arif JM. 2016. Diabetic Nephropathy- A Major Macrovascular Complication. International Journal of Pharma-ceutical Research & Allied Sciences;5.pp.132-158.
  25. Ahmed SB, Hovind P, Parving H-H, Rossing P, Price DA, Laffel LM, et al.2005.Oral Contraceptives, Angio-tensin-Dependent Renal Vaso-constriction, and Risk of Diabetic Nephropathy. DIABETES CARE;28.
  26. Lazarevic G, Antic S, Cvetkovic T, Vlahovic P, Tasic I, Stefanovic V. 2006. A Physical Activity Programme and Its Effects on Insulin Resistance and Oxidative Defense in Obese Male Patients With Type 2 Diabetes Mellitus. Diabetes Metab;32.pp.583-590.
  27. Hoque S., Muttalib MA., Islam MI., PA. K, Akter N, T. A. 2017. Prevalence of Nephropathy with Evaluation of HbA1c Level and other Associated Risk Factors in Type 2 Diabetic Patients in a Tertiary Level Hospital. KYAMC Journal;8(1).
  28. Adiga US, Malawadi B. 2016. Uric acid in Type 2 Diabetes mellitus with nephropathy. International Journal of Clinical Biochemistry and Research; 3(3).pp.340-242.
  29. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, M.Weinberg J, Aschengrau A, et al.2010.High-Normal Serum Uric Acid Increases Risk of Early Progressive Renal Function Loss in Type 1 Diabetes. Diabetes Care; 33.pp.1337-1343.
  30. Satirapoj B, Adler SG.2014. Compre-hensive Approach to Diabetic Nephropathy. Kidney Research and Clinical Practice;33.pp.121–131.
  31. Maric-Bilkan C. 2013. Obesity and Diabetic Kidney Disease. Med Chin North Am;97.pp.59-74.
  32. Chen H-M, Shen W-W, Ge Y-C, Zhang Y-D, Xie H-L, Liu Z-H. 2013. The Relationship Between Obesity and Diabetic Nephropathy in China. BMC Nephrology;14(69).