Faktor Risiko Gagal Konversi Pengobatan Penderita Baru Tuberkulosis Paru Fase Intensif (Studi di Kota Bandar Lampung)

*Olys Olys  -  Dinas Kesehatan Kabupaten Mesuji, Indonesia
Bagoes Widjanarko  -  Universitas Diponegoro, Indonesia
Suharyo Hadisaputro  -  Universitas Diponegoro, Indonesia
Djoko Trihadi Lukmono  -  Universitas Diponegoro, Indonesia
Published: 8 Aug 2016.
Open Access

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Language: ID
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Abstract

Background : Tuberculosis along with HIV is a major cause of death worldwide. Globally in
2014, there were an estimated 9.6 million people get TB. Achievement conversion rate of TB
in the province of Lampung based Riskesdas 2010 and 2013 experienced a sharp decline of
90% in 2011 to only 38.1% in 2014 (National target> 85%). Internal and external factors are closely related to the incident, it is necessary to do in-depth study to determine the factors that influence the conversion failure of TB patients in the intensive phase of treatment.

Methods : This research was analytic observational cohort design. The study population was patients with pulmonary tuberculosis in the city of Bandar Lampung starting treatment. The total sample of 126, the dependent variable was the incidence of failed conversion, independent variables are internal factors (positive gradation, BMI, hemoglobin levels and symptoms of anxiety of patients) and external factors (smoking, alcohol consumption and the role of health workers). Samples were obtained by exhaustive sampling.

Results : AFB positive gradation (aRR=12,7; 95%CI: 3,580 to 45,539; p=0,000), the role of
health workers (aRR=9,8; 95%CI : 3,451 to 28,221; p=0,000) and consumption of alcoholic beverages (aRR=5,5; 95%CI : 1,927 to 15,566; p=0,001) proved to be a risk factor for conversion failure with probability event together amounted to 95.3%.

Conclusion : The risk factors that affect the incidence of TB is conversion failure patients with 2+ and 3+ BTA gradation, alcohol consumption and the role of health workers.

 

Keywords
lycaemic control status in pregnancy with diabetes; risk factors

Article Metrics:

  1. World Health Organization. 2015. Global Tuberculosis Report 2015. 20th Edition WHO.pp.1-3.
  2. Tumaini J. Nagu, Donna Spiegelman, Ellen Hertzmark, et al. 2014. Anemia at The Initiation of Tuberculosis Therapy Is Associated with Delayed Sputum Conversion among Pulmonary Tuberculosis Patients in Dares Salaam, Tanzania..J. PLoS ONE 9(3): e91229.
  3. Bernida I, Suryatenggara W, Mangunegoro H. 1994. Pengaruh Cara Pemberian Obat Anti Tuberculosis Terhadap Fungsi Hati dan Konversi Sputum pada Pasien Tuberkulosis Paru.pp.17-24.
  4. Rajana R, dkk. 2008. Faktor-Faktor Risiko Gagal Konversi Dahak Penderita TB Setelah Pengobatan dengan Strategi DOTs Tahap Intensif di Kab Halmahera Tengah Tahun 2008. Yogyakarta: Ilmu Kesehatan Masyarakat UGM.
  5. Dinas Kesehatan Kota Bandar Lampung. 2015. Data Laporan Rutin Triwulan I 2015 Program P2 TB Paru. Bandar Lampung: Dinkes Lampung.
  6. Morton, Richard. 2008. Panduan Studi Epidemiologi dan Biostatistik. Jakarta: EGC.pp.53.
  7. Lemeshow, S. & David WH. 1997. Besar Sampel dalam Penelitian Kesehatan (terjemahan). Yogyakarta: Gadjah Mada University Press.pp.119.
  8. Nwokeukwu H. I., Awujo D. N., Emma U. 2013. Association of Sputum Conversion and Outcome With Initial Smear Grading Among New Smear Positive Tuberculosis Patients In A Tertiary Health Facility. South East Zone Nigeria. J Den Med Sciences; 4(6).pp.4-9.
  9. Caetano MP, Carvalho A, Valente I, et al. 2012. Predictors of Delayed Sputum Smear and Culture Conversion Among A Portuguese Population With Pulmonary Tuberculosis. J Rev Port Pneumol;18(2).pp.72-79.
  10. Parikh Raunak, Nataraj Gita, Kanade Swapna, et al. 2012. Time to Sputum Conversion in Smear Positive Pulmonary TB Patients on Category I DOTS and Factors Delaying it. JAPI;60.pp.22-26.