DOI: https://doi.org/10.14710/hnhs.9.1.2026.%25p

Durasi Pengobatan Berpengaruh terhadap Jumlah Tiap Jenis Leukosit Penderita Tuberkulosis Paru

1Universitas Timor, Indonesia

2Politeknik Kesehatan Kementerian Kesehatan Kupang, Kupang, Indonesia

3Universitas Mandala Waluya, Kendari, Indonesia

4 Universitas Citra Bangsa, Kupang, Indonesia

View all affiliations
Received: 14 Jun 2026; Revised: 18 Jun 2026; Accepted: 1 Jul 2026; Available online: 9 Jul 2026; Published: 30 Jun 2026.
Open Access Copyright 2026 Holistic Nursing and Health Science

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract
Pulmonary tuberculosis (TB) remains one of the major public health challenges in Indonesia. The immune response to TB infection may be influenced by the treatment duration, which can be observed through changes in the composition of leukocyte types in patients undergoing therapy. However, limited studies identify the duration of TB treatment with leukocyte type count among pulmonary TB patients. This study aimed to analyze the influence of the treatment duration on leukocyte type count in pulmonary TB patients. This study implied an analytical observational design and involved 60 pulmonary TB patients selected from several health facilities. Data were collected through laboratory examinations to assess leukocyte profiles and medical record reviews to determine the treatment phase based on the duration of therapy. The data were analyzed univariately to describe the respondents’ characteristics by age and sex, and bivariate analysis used simple linear regression to assess the relationship between treatment phase and changes in leukocyte proportions. Findings showed significant effects of the treatment duration on the proportions of eosinophils (p = 0.032), lymphocytes (p = 0.005), and neutrophils (p = 0.018). Patients in a longer treatment phase exhibited an increase in lymphocyte counts, while eosinophils and neutrophils tended to decrease. These results indicate that the immune response to TB adjusts over time and that leukocyte profiles may serve as indicators of treatment effectiveness. This study provides valuable insights for healthcare professionals in understanding the immune dynamics of TB patients and optimizing therapeutic strategies to enhance treatment outcomes.

 

Abstrak

Tuberkulosis paru masih menjadi tantangan besar kesehatan masyarakat di Indonesia. Respon imun terhadap infeksi tuberkulosis paru dapat mengalami perubahan sesuai dengan lama pengobatan, yang tercermin melalui perbedaan proporsi jenis leukosit pada pasien yang menjalani terapi. Penelitian yang mengindentifikasi pengaruh lama terapi tuberkulosis terhadap jumlah tiap jenis leukosit penderita tuberkulosis paru masih terbatas. Penelitian ini bertujuan untuk mengetahui pengaruh lama pengobatan terhadap tiap jenis leukosit (eosinofil, limfosit, monosit, dan neutrofil) pada pasien tuberkulosis paru. Desain penelitian ini adalah observasional analitik dengan jumlah sampel 60 pasien dari berbagai fasilitas layanan kesehatan. Data dikumpulkan melalui pemeriksaan darah dan penelaahan rekam medis untuk menentukan lama pengobatan. Analisis univariat digunakan untuk menggambarkan karakteristik responden, sedangkan uji regresi linear digunakan untuk mengevaluasi hubungan antara lama pengobatan dan komposisi jenis leukosit. Hasil menunjukkan adanya pengaruh yang signifikan antara lama pengobatan dengan jumlah eosinofil (p = 0,032), limfosit (p = 0,005), dan neutrofil (p = 0,018). Semakin lama pengobatan dijalani, terjadi peningkatan limfosit serta penurunan eosinofil dan neutrofil. Temuan ini menunjukkan adanya adaptasi imun selama terapi tuberkulosis paru dan dapat menjadi dasar dalam memantau efektivitas pengobatan.

 

 

Note: This article has supplementary file(s).

Fulltext |  common.other
Untitled
Subject
Type Other
  Download (11KB)    Indexing metadata
Email colleagues
Keywords: Leukosit; lama pengobatan; tuberkulosis paru;

Article Metrics:

Article Info
Section: Original Research Articles
Language : ID
  1. Abay, F., Yalew, A., & Shibabaw, A. (2018). The prevalence of hematological abnormalities among pulmonary tuberculosis patients in Ethiopia. BMC Hematology, 18(1), 1. https://doi.org/10.1186/s12878-018-0101-7
  2. Aminuddin, M. F., & Soda, A. (2025). Gambaran Jumlah dan Jenis Leukosit pada pasien Rumah Sakit Umum Daerah Abdul Wahab Sjahranie Samarinda Overview of the Number and Type of Leukocytes in patients of Abdul Wahab Sjahranie Samarinda Regional General Hospital. 5(1), 47–52
  3. Aulina Hanifah, D., & Siyam, N. (2021). Faktor yang Berhubungan dengan Status Kesembuhan Pasien TB Paru pada Usia Produktif (15-49 Tahun) Studi Kasus di Puskesmas Bandarharjo Kota Semarang. Ijphn, 1(3), 523–532. http://journal.unnes.ac.id/sju/index.php/IJPHN
  4. Dorhoi, A., & Kaufmann, S. H. E. (2016). Pathology and immune reactivity: Understanding multidimensionality in pulmonary tuberculosis. Seminars in Immunopathology, 38(2), 153–166. https://doi.org/10.1007/s00281-015-0531-y
  5. Ergiana, S. D., Wardani, D. P. K., Sudarsono, T. A., & Mulyanto, A. (2022). Hubungan Kadar C-Reactive Protein dengan Jumlah Leukosit Penderita Tuberkulosis Paru pada Lama Pengobatan 0 dan 2 Bulan di BKPM Purwokerto. Jurnal Surya Medika, 8(2), 62–77. https://doi.org/10.33084/jsm.v8i2.3482
  6. Etna, M. P., Giacomini, E., Severa, M., & Coccia, E. M. (2014). Pro- and anti-inflammatory cytokines in tuberculosis: A two-edged sword in TB pathogenesis. Seminars in Immunology, 26(6), 543–551. https://doi.org/10.1016/j.smim.2014.09.011
  7. Haliza, N. E., Wardani, D. P. K., Sudarsono, T. A., & Mulyanto, A. (2022). Hubungan Kadar C Reactive Protein dengan Jumlah Neutrofil Penderita Tuberkulosis Paru pada Lama Pengobatan 0 dan 6 Bulan di BKPM Purwokerto. Jurnal Surya Medika, 8(2), 37–44. https://doi.org/10.33084/jsm.v8i2.3480
  8. Hartono, R., TANDJUNGBULU, Y. F., Virgiawan, A. R., Rafika, R., & Manasa, P. S. (2024). Hasil Pemeriksaan Genexpert Terhadap Jumlah Dan Jenis Sel Leukosit Pada Pasien Suspek Tuberkulosis. Jurnal Media Analis Kesehatan, 15(1), 96–111. https://doi.org/10.32382/jmak.v15i1.731
  9. Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC Hematology, 16(1), 1–11. https://doi.org/10.1186/s12878-015-0037-1
  10. Ke lele, Y., Wahyuni, C. U., Bebengu, Y. B., & Sondakh, C. S. (2024). Evaluasi Sistem Surveilans Tuberkulosis Berdasarkan Pendekatan Sistem Di Kabupaten Kupang, Provinsi Nusa Tenggara Timur. Jambura Journal of Health Sciences and Research, 6(2), 121–135. https://doi.org/10.35971/jjhsr.v6i2.22308
  11. Khaironi, S., Rahmita, M., & Siswani, R. (2017). Gambaran Jumlah Leukosit Dan Jenis Leukosit pada Pasien Tuberkulosis Paru Sebelum Pengobatan Dengan Setelah Pengobatan Satu Bulan Intensif di Puskesmas Pekanbaru. Analis Kesehatan Klinikal Sains, 2(5), 1–11
  12. Kiran, B., Cagatay, T., Clark, P. M., Kosar, F., Cagatay, P., Kalyoncu, A. F., & Yildiz, A. (2010). Can immune parameters be used as markers to monitor response to antituberculosis treatment? Tuberculosis, 90(6), 378–382. https://doi.org/10.1016/j.tube.2010.08.001
  13. Lestari, N. P. W. A., Dedy, M. A. E., Artawan, I. M., & Buntoro, I. F. (2022). Perbedaan Usia Dan Jenis Kelamin Terhadap Ketuntasan Pengobatan Tb Paru Di Puskesmas Di Kota Kupang. Cendana Medical Journal, 10(1), 24–31. https://doi.org/10.35508/cmj.v10i1.6802
  14. Malehere, E., Regaletha, T. A. L., & Dodo, D. O. (2023). Implementation of The Pulmonary Tuberculosis Control Program at Sikumana Public Health Center. Journal of Public Health for Tropical and Coastal Region, 6(2), 55–65. https://doi.org/10.14710/jphtcr.v6i2.19004
  15. Marissa, N., & Nur, A. (2014). GAMBARAN INFEKSI MYCOBACTERIUM TUBERCULOSIS PADA ANGGOTA RUMAH TANGGA PASIEN TB PARU (Studi Kasus di Wilayah Kerja Puskesmas Darul Imarah Kabupaten Aceh Besar). Media Penelitian Dan Pengembangan Kesehatan, 24(2), 89–94. https://doi.org/10.22435/mpk.v24i2.3566.89-94
  16. Novita, E., & Ismah, Z. (2014). STUDI KARAKTERISTIK PASIEN TUBERKULOSIS DI PUSKESMAS SEBERANG ULU 1 PALEMBANG. Unnes Journal of Public Health, 3(1), 1–10. https://doi.org/10.15294/ujph.v6i4.15219
  17. Sunarmi, S., & Kurniawaty, K. (2022). Hubungan Karakteristik Pasien Tb Paru Dengan Kejadian Tuberkulosis. Jurnal ’Aisyiyah Medika, 7(2), 182–187. https://doi.org/10.36729/jam.v7i2.865
  18. Susilawati, N. M., Foekh, N. P., & Bria, M. (2023). Pemberdayaan Kader Sebaya Dalam Pencegahan TB Di Desa Bone Kecamatan Nekamese Kabupaten Kupang. Jurnal Kabar Masyarakat, 1(4), 45–52. https://doi.org/10.54066/jkb.v1i4.980
  19. Susilawaty, A., Basri, S., Haerana, B. T., Ane, R. La, Mappau, Z., & Ikhtiar, M. (2024). The Risk Factors Contributing to The Occurrence of Pulmonary Tuberculosis in The Small Island of South Sulawesi, Indonesia. Public Health of Indonesia, 10(4), 104–116. https://doi.org/10.36685/PHI.V10I4.876

Last update:

No citation recorded.

Last update:

No citation recorded.