skip to main content

Aktivitas Farmakologis Terpenoid Teh (Camelia sinensis) : Sebuah Kajian Naratif

*Andika Putra Pamera  -  Prodi S1 Farmasi, Universitas Telogorejo, Jl Puri Anjasmoro, Semarang, Indonesia, Indonesia
Received: 29 Dec 2025; Revised: 6 Feb 2026; Accepted: 6 Mar 2026; Available online: 30 Jul 2026; Published: 29 Jul 2026.

Citation Format:
Abstract
Teh (Camellia sinensis) merupakan salah satu jenis tumbuhan yang hidup di daerah subtropis dan telah dikonsumsi secara turun temurun karena sebagai suplemen makanan. Teh memiliki berbagai senyawa biomarker seperti flavonoid, polifenol, tannin dan terpenoid.  Terpenoid dalam teh yang dikaitkan dengan aktivitas antibakteri seperti antijamur, antiinflamasi dan antidiabetes. Penelitian ini dilakukan untuk mengintegrasikan senyawa terpenoid dalam teh terhadap potensi aktivitas farmakologis yang dapat dihasilkan. Kajian ini merupakan narrative review yang menggunakan instrumen PRISMA yang melibatkan 6134 publikasi yang berasal dari database scopus dan Web of Science (WoS) dengan rentang publikasi 5 tahun terakhir (2020-2025). Tinjauan ini memperoleh 7 literatur dan diketahui bahwa terpenoid dalam ekstrak teh terdiri dari 50-120 komponen terpenoid dengan  aktivitas farmakologis yang baik sebagai antibakteri, antikolesterol, antidiabetes, antikanker dan antioksidan. Mekanisme yang terbentuk pada aktivitas farmakologi terpenoid bekerja sinergis dengan senyawa fenolik maupun flavonoid. Terpenoid merupakan salah satu senyawa mayor dalam tumbuhan teh (Camellia sinensis) dan memiliki potensi aktivitas farmakologi pada berbagai jenis penyakit. Aspek ini perlu diteliti untuk memberikan pemahaman lanjutan secara komprehensif pada aspek efektivitas dan keamanan sehingga membuka potensi pemanfaatan terpenoid dalam teh yang lebih rasional dan aman bagi kesehatan manusia.

 

   
Keywords: Terpenoid; Teh; Farmakologi; Antioksidan; Antimikroba.

Article Metrics:

Article Info
  1. Ajmal, S. et al. (2022) ‘Evaluation of Anti-cancer and Anti-proliferative Activity of Medicinal Plant Extracts (Saffron, Green Tea, Clove, Fenugreek) on Toll Like Receptors Pathway’, Natural Product Sciences, 28(3), pp. 121–129
  2. Andrew, I. et al. (2022) ‘Bioactive Components and Antioxidant Properties of Aqueous Leaf Extract of Fresh and Processed Camellia sinensis in Alloxan-induced Albino Rats’, Asian Journal of Biotechnology and Bioresource Technology, pp. 62–74. DOI: https://doi.org/10.9734/ajb2t/2022/v8i330130
  3. B, S., R, P. and Jayaraman, S. (2024) ‘In Vitro Analysis of Camellia sinensis Leaf Extract Against Diabetes Mellitus’, Cureus, 16(6). DOI: https://doi.org/10.7759/cureus.62794
  4. Bag, S. et al. (2022) ‘Tea and its phytochemicals: Hidden health benefits & modulation of signaling cascade by phytochemicals’, Food Chemistry, 371, p. 131098
  5. https://doi.org/10.1016/j.foodchem.2021.131098
  6. Bashiru, I., Aminu I., Umar, C.A.O. and S.A.A. (2020) ‘Phytochemical Screening , Proximate Analysis and Antioxidant Vitamins of Green Tea’, Caliphate Journal of Science & Technology, 1(March 2019), pp. 1–5
  7. Cañellas-Santos, M. et al. (2023) ‘Anti-Inflammatory and Anti-Quorum Sensing Effect of Camellia sinensis Callus Lysate for Treatment of Acne’, Current Issues in Molecular Biology, 45(5), pp. 3997–4016. DOI: https://doi.org/10.3390/cimb45050255
  8. Chen, C. et al. (2022) ‘Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis)’, Metabolites, 12(3). DOI: https://doi.org/10.3390/metabo12030204
  9. Chen, P. et al. (2022) ‘Quantitatively Unravelling the Impact of High Altitude on Oolong Tea Flavor from Camellia sinensis Grown on the Plateaus of Tibet’, Horticulturae, 8(6). DOI: https://doi.org/10.3390/horticulturae8060539
  10. Chen, S. et al. (2023) ‘Identification of QTL controlling volatile terpene contents in tea plant (Camellia sinensis) using a high-aroma “Huangdan” x “Jinxuan” F1 population’, Frontiers in Plant Science, 14(March), pp. 1–14. DOI: https://doi.org/10.3389/fpls.2023.1130582
  11. Dai, X. et al. (2020) ‘Discovery and characterization of tannase genes in plants: roles in hydrolysis of tannins’, New Phytologist, 226(4), pp. 1104–1116. DOI: https://doi.org/10.1111/nph.16425
  12. El-Aswad, A.F., Aisu, J. and Khalifa, M.H. (2023) ‘Biological activity of tannins extracts from processed Camellia sinensis (black and green tea), Vicia faba and Urtica dioica and Allium cepa essential oil on three economic insects’, Journal of Plant Diseases and Protection, 130(3), pp. 495–508. DOI: https://doi.org/10.1007/s41348-022-00680-x
  13. Fahmi, A. et al. (2024) ‘PHYTOCHEMICAL, ANTIMICROBIAL, ANTIOXIDANT, AND CATECHIN ANALYSIS OF GREEN TEA (Camellia sinensis var assamica) FROM NORTH SUMATERA, INDONESIA’, Rasayan Journal of Chemistry, 17(2), pp. 417–424. DOI: https://doi.org/10.31788/RJC.2024.1728738
  14. Feng, Z. et al. (2020) ‘Characterization of the orchid-like aroma contributors in selected premium tea leaves’, Food Research International, 129, p. 108841. DOI: https://doi.org/10.1016/j.foodres.2019.108841
  15. Gholamali, S. et al. (2022) ‘Evaluation of polycyclic aromatic hydrocarbons (PAHs) in bottled water samples (non-carbonated, mineral, carbonated and carbonated flavored water) in Tehran with MSPE-GC/MS method: a health risk assessment’, Applied Biological Chemistry, 65(3), pp. 1–12. DOI: https://doi.org/10.1186/s13765-022-00696-9
  16. Göksu Sürücü, C. et al. (2024) ‘Brewing method-dependent changes of volatile aroma constituents of green tea (Camellia sinensis L.)’, Food Science and Nutrition, (4), pp. 7186–7201. DOI: https://doi.org/10.1002/fsn3.4307
  17. Hasan, M.R. et al. (2024) ‘Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn’, Heliyon, 10(1), p. e23514. DOI: https://doi.org/10.1016/j.heliyon.2023.e23514
  18. Hosen, M.E. et al. (2024) ‘Evaluation of biological activities of Camellia sinensis and in silico approach against Rgg2 protein of Streptococcus dysgalactiae’, Arabian Journal of Medicinal and Aromatic Plants, 10(1), pp. 20–51. DOI: https://doi.org/10.48347/IMIST.PRSM/ajmap-v10i1.50223
  19. Hsu, Y.-W., Chen, W.-K. and Tsai, C.-F. (2022) ‘Senescence-Mediated Redox Imbalance in Liver and Kidney: Antioxidant Rejuvenating Potential of Green Tea Extract’, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(1). DOI: https://doi.org/10.3390/ijerph19010260
  20. Huang, W. et al. (2022) ‘Sensomics analysis of the effect of the withering method on the aroma components of Keemun black tea’, Food Chemistry, 395, p. 133549. DOI: https://doi.org/10.1016/j.foodchem.2022.133549
  21. Huang, Y. et al. (2021) ‘Research progress in biosynthesis and regulation of plant terpenoids’, Biotechnology and Biotechnological Equipment, 35(1), pp. 1800–1809. DOI: https://doi.org/10.1080/13102818.2021.2020162
  22. Hun, C.J. et al. (2022) ‘Confirmation of plant-derived exosomes as bioactive substances for skin application through comparative analysis of keratinocyte transcriptome’, Applied Biological Chemistry, 65(1), pp. 1–9. DOI: https://doi.org/10.1186/s13765-022-00676-z
  23. Jeong, H.W. et al. (2021) ‘Antihypertriglyceridemia activities of naturally fermented green tea, Heukcha, extract through modulation of lipid metabolism in rats fed a high-fructose diet’, Food Science and Biotechnology, 30(12), pp. 1581–1591. DOI: https://doi.org/10.1007/s10068-021-00979-9
  24. Jiang, H. et al. (2019) ‘Dynamic change in amino acids, catechins, alkaloids, and gallic acid in six types of tea processed from the same batch of fresh tea (Camellia sinensis L.) leaves’, Journal of Food Composition and Analysis, 77, pp. 28–38. DOI: https://doi.org/10.1016/j.jfca.2019.01.005
  25. Jiang, H. et al. (2020) ‘Chemical composition of a supercritical fluid (Sfe-CO2) extract from baeckea frutescens L. leaves and its bioactivity against two pathogenic fungi isolated from the tea plant (Camellia sinensis (L.) O. Kuntze)’, Plants, 9(9), pp. 1–15. DOI: https://doi.org/10.3390/plants9091119
  26. Jin, J. et al. (2020) ‘Scenarios of genes-to-terpenoids network led to the identification of a novel α/β-farnesene/β-ocimene synthase in Camellia sinensis’, International Journal of Molecular Sciences, 21(2), pp. 1–14. DOI: https://doi.org/10.3390/ijms21020655
  27. Kim, T. et al. (2020) ‘Therapeutic potential of volatile terpenes and terpenoids from forests for inflammatory diseases’, International Journal of Molecular Sciences, 21(6). DOI: https://doi.org/10.3390/ijms21062187
  28. Liu, Y. et al. (2022) ‘Gui Shao Tea Extracts Inhibit Gastric Cancer Growth in Vitro and in Vivo and Prolong Survival in Nude Mice’, Frontiers in Bioscience - Landmark, 27(8). DOI: https://doi.org/10.31083/j.fbl2708250
  29. Majumder, S., Ghosh, A. and Bhattacharya, M. (2020) ‘Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome’, Bulletin of the National Research Centre, 44(1). DOI: https://doi.org/10.1186/s42269-020-00397-7
  30. Mirmojarabian, S. et al. (2022) ‘ Phytochemical properties and antiviral effect of green tea ( Camellia sinensis ) extract on adenovirus in vitro ’, Journal of Shahrekord University of Medical Sciences, 24(3), pp. 104–110. DOI: https://doi.org/10.34172/jsums.2022.17
  31. De Moraes, M.D.R. et al. (2021) ‘Protective effect of green tea catechins on eroded human dentin: an in vitro/in situ study’, Brazilian Oral Research, 35, pp. e108–e108. DOI: https://doi.org/10.1590/1807-3107bor-2021.vol35.0108
  32. Nie, C. et al. (2019) ‘Comparison of different aroma-active compounds of Sichuan Dark brick tea (Camellia sinensis) and Sichuan Fuzhuan brick tea using gas chromatography–mass spectrometry (GC–MS) and aroma descriptive profile tests’, European Food Research and Technology, 245(9), pp. 1963–1979. DOI: https://doi.org/10.1007/s00217-019-03304-1
  33. Ninkuu, V. et al. (2021) ‘Biochemistry of terpenes and recent advances in plant protection’, International Journal of Molecular Sciences, 22(11). DOI: https://doi.org/10.3390/ijms22115710
  34. Niu, S. et al. (2019) ‘Genetic diversity, linkage disequilibrium, and population structure analysis of the tea plant (Camellia sinensis) from an origin center, Guizhou plateau, using genome-wide SNPs developed by genotyping-by-sequencing’, BMC Plant Biology, 19(1), p. 328. DOI: https://doi.org/10.1186/s12870-019-1917-5
  35. Omran, A.M., Al Sa’ady, A.T. and Saleh, R.H. (2023) ‘Phytochemical Screening, Antibacterial Activity, and Chromatographic Study of Camellia sinensis’, Medical Journal of Babylon, 20(4), pp. 790–796. DOI: https://doi.org/10.4103/MJBL.MJBL_455_23
  36. Parveen, A. et al. (2023) ‘The Chemistry, Sensory Properties and Health Benefits of Aroma Compounds of Black Tea Produced by Camellia sinensis and Camellia assamica’, Horticulturae, 9(12). DOI: https://doi.org/10.3390/horticulturae9121253
  37. Pereira, A.G. et al. (2022) ‘Camellia japonica: A phytochemical perspective and current applications facing its industrial exploitation’, Food Chemistry: X, 13(February), p. 100258. DOI: https://doi.org/10.1016/j.fochx.2022.100258
  38. Del Prado-Audelo, M.L. et al. (2021) ‘Therapeutic Applications of Terpenes on Inflammatory Diseases’, Frontiers in Pharmacology, 12(August), pp. 1–7. DOI: https://doi.org/10.3389/fphar.2021.704197
  39. Prayoga, M.K. et al. (2022) ‘Quality diversity of 35 tea clones (Camellia sinensis var. sinensis) processed for green tea’, Biodiversitas, 23(2), pp. 810–816. DOI: https://doi.org/10.13057/biodiv/d230227
  40. Qin, C. et al. (2024) ‘Chemical profile and in-vitro bioactivities of three types of yellow teas processed from different tenderness of young shoots of Huoshanjinjizhong (Camellia sinensis var. sinensis)’, Food Chemistry: X, 24(May), p. 101809. DOI: https://doi.org/10.1016/j.fochx.2024.101809
  41. Rafique, S. et al. (2023) ‘Investigation of the antimicrobial, antioxidant, hemolytic, and thrombolytic activities of Camellia sinensis, Thymus vulgaris, and Zanthoxylum armatum ethanolic and methanolic extracts’, Food Science and Nutrition, 11(10), pp. 6303–6311. DOI: https://doi.org/10.1002/fsn3.3569
  42. Rahayu, R.P. et al. (2018) ‘The immunomodulatory effect of green tea (Camellia sinensis) leaves extract on immunocompromised Wistar rats infected by Candida albicans’, Veterinary World, 11(6), pp. 765–770. DOI: https://doi.org/10.14202/vetworld.2018.765-770
  43. Ren, H. et al. (2022) ‘Integrative Transcriptome and Proteome Analysis Reveals the Absorption and Metabolism of Selenium in Tea Plants [Camellia sinensis (L.) O. Kuntze]’, Frontiers in Plant Science, 13(February), pp. 1–14. DOI: https://doi.org/10.3389/fpls.2022.848349
  44. Rizka, G.A., Makmum, A. and Safei, I. (2025) ‘Pengaruh Pemberian Seduhan Daun Teh Hijau (Camellia sinensis) terhadap Kadar Kolesterol Total dan High Density Lipoprotein (HDL) pada Mencit (Mus Musculus) yang Menderita Diabetes Melitus Tipe 2’, The Indonesian Journal of General Medicine, 13(3), pp. 1–11. DOI: https://doi.org/10.70070/6rwmvs60
  45. Rubab, S., Rizwani, Ghazala H., et al. (2022) ‘Establishment of Pharmacognostic Standards of Different Morphological Parts of Camellia sinensis L. Grown in Pakistan’, Pakistan Journal of Botany, 54(4), pp. 1557–1565. DOI: https://doi.org/10.30848/PJB2022-4(29)
  46. Rubab, S., Rizwani, Ghazala H, et al. (2022) ‘Phytochemical and Pharmacological Potential of Camellia sinensis L.’, Pakistan Journal of Zoology, 55(2), pp. 1–10. DOI: https://doi.org/10.17582/journal.pjz/20210815170852
  47. Sheikh, I. et al. (2021) ‘Cancer chemoprevention by flavonoids, dietary polyphenols and terpenoids’, Biointerface Research in Applied Chemistry, 11(1), pp. 8502–8537. DOI: https://doi.org/10.33263/BRIAC111.85028537
  48. Shi, L. et al. (2021) ‘Effect of a combined microwave-assisted drying and air drying on improving active nutraceutical compounds, flavor quality, and antioxidant properties of Camellia sinensis L. (cv. Longjing 43) flowers’, Food Quality and Safety, 5, pp. 1–7. DOI: https://doi.org/10.1093/fqsafe/fyaa040
  49. Sil, S.K. and Mukherjee, N. (2021) ‘Bioactive Compounds of Tea ( Camellia sinensis ) Flowers’, International Journal of Research in Applied, Natural and Social Sciences, 9(3), pp. 11–22
  50. Singh, M.K. et al. (2022) ‘A review on Immunostimulatory and antioxidant potential of herbs, Curcuma longa L., Camellia sinensis L. Zingiber officinale and Allium sativum Linn. in fish health: a sustainable approach for a healthy aquaculture’, Ecology, Environment and Conservation, pp. 1431–1445. DOI: https://doi.org/10.53550/EEC.2022.v28i03.047
  51. Sobhanian, S.A. et al. (2024) ‘Glucose and Lipid-Lowering Activities of Some Bioactive Extracted Components from Herbs (Camellia sinensis, Matricaria Chamomilla and Carum Carvi) in Streptozotocin-diabetic Rats: Intelligent Method for Herbal Medicines Production with Selected Active Ing’. DOI: https://doi.org/10.21203/rs.3.rs-5321019/v1
  52. Suksathan, R. et al. (2021) ‘Phytochemical and nutritional compositions and antioxidants properties of wild edible flowers as sources of new tea formulations’, NFS Journal, 24(March), pp. 15–25. DOI: https://doi.org/10.1016/j.nfs.2021.06.001
  53. Tang, Jiandong et al. (2024) ‘Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking’, Foods, 13(21). DOI: https://doi.org/10.3390/foods13213435
  54. Teixeira, A.M. and Sousa, C. (2021) ‘A review on the biological activity of camellia species’, Molecules, 26(8), pp. 1–25. DOI: https://doi.org/10.3390/molecules26082178
  55. Thelma, E.I. et al. (2020) ‘Haematology, serum biochemistry and histopathological findings associated with sub-chronic administration of methanol leaf extract of Pterocarpus santalinoides DC in albino rats’, African Journal of Pharmacy and Pharmacology, 14(5), pp. 136–146. DOI: https://doi.org/10.5897/ajpp2020.5143
  56. Uba, J.O. et al. (2022) ‘Bioactive and nutrient composition of Camellia sinensis (Tea plant) leaves’, Journal of Medicinal Plants Studies, 10(6), pp. 06–14. DOI: https://doi.org/10.22271/plants.2022.v10.i6a.1481
  57. Urme, S.R.A. et al. (2024) ‘Antimicrobial Activity of Tea and Agarwood Leaf Extracts Against Multidrug-Resistant Microbes’, BioMed research international, 2024, p. 5595575. DOI: https://doi.org/10.1155/bmri/5595575
  58. Wang, S.-T. et al. (2020) ‘Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer’, World Journal of Gastroenterology, 26(6), pp. 562–597. DOI: https://doi.org/10.3748/wjg.v26.i6.562
  59. Wei, J. et al. (2023) ‘Biosynthesis and the Transcriptional Regulation of Terpenoids in Tea Plants (Camellia sinensis)’, International Journal of Molecular Sciences, 24(8). DOI: https://doi.org/10.3390/ijms24086937
  60. Widowati, W. et al. (2021) ‘Potential of Black Tea (Camellia sinensis (L.) O. Kuntze) Extract as Anti-oxidant and Skin Anti-aging’, in Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science. SCITEPRESS - Science and Technology Publications, pp. 65–73. DOI: https://doi.org/10.5220/0010744400003113
  61. Wu, S. et al. (2023) ‘Histone deacetylase CsHDA6 mediates the regulated formation of the anti-insect metabolite α-farnesene in tea (Camellia sinensis)’, Plant Science, 326, pp. 1–19. DOI: https://doi.org/10.1016/j.plantsci.2022.111501
  62. Xu, K. et al. (2022) ‘Non-Targeted Metabolomics Analysis Revealed the Characteristic Non-Volatile and Volatile Metabolites in the Rougui Wuyi Rock Tea (Camellia sinensis) from Different Culturing Regions’, Foods, 11(12). DOI: https://doi.org/10.3390/foods11121694
  63. Yan, L. et al. (2022) ‘Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology’, Frontiers in Molecular Biosciences, 9(March), pp. 1–17. DOI: https://doi.org/10.3389/fmolb.2022.862932
  64. Yang, C.S. and Zhang, J. (2019) ‘Studies on the Prevention of Cancer and Cardiometabolic Diseases by Tea: Issues on Mechanisms, Effective Doses, and Toxicities’, Journal of Agricultural and Food Chemistry, 67(19), pp. 5446–5456. DOI: https://doi.org/10.1021/acs.jafc.8b05242
  65. Yang, P. et al. (2022) ‘Characterization of Key Aroma-Active Compounds in Rough and Moderate Fire Rougui Wuyi Rock Tea ( Camellia sinensis ) by Sensory-Directed Flavor Analysis and Elucidation of the Influences of Roasting on Aroma’, Journal of Agricultural and Food Chemistry, 70(1), pp. 267–278. DOI: https://doi.org/10.1021/acs.jafc.1c06066
  66. Yazdanpanah, Z. et al. (2023) ‘The effect of green tea (Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial’, Frontiers in Nutrition, 10(December), pp. 1–10. DOI: https://doi.org/10.3389/fnut.2023.1253275
  67. Ye, J. et al. (2023) ‘Effect of processing on aroma intensity and odor characteristic of Shuixian (Camellia sinensis) tea’, Food Chemistry: X, 17(November 2022), pp. 100616. DOI: https://doi.org/10.1016/j.fochx.2023.100616
  68. Yun, J. et al. (2021) ‘Use of headspace GC/MS combined with chemometric analysis to identify the geographic origins of black tea’, Food Chemistry, 360, p. 130033. DOI: https://doi.org/10.1016/j.foodchem.2021.130033
  69. Zeng, H. et al. (2023) ‘Metabolomics Analysis Reveals the Accumulation Patterns of Flavonoids and Volatile Compounds in Camellia oleifera Petals with Different Color’, Molecules, 28(21). DOI: https://doi.org/10.3390/molecules28217248
  70. Zhou, H.-C. et al. (2020) ‘Analysis of Terpene Synthase Family Genes in Camellia sinensis with an Emphasis on Abiotic Stress Conditions’, Scientific Reports, 10(1), p. 933. DOI: https://doi.org/10.1038/s41598-020-57805-1
  71. Zhou, X. et al. (2020) ‘Metabolism of gallic acid and its distributions in tea (Camellia sinensis) plants at the tissue and subcellular levels’, International Journal of Molecular Sciences, 21(16), pp. 1–13. DOI: https://doi.org/10.3390/ijms21165684
  72. Zhou, X. et al. (2024) ‘The Changes in Metabolites, Quality Components, and Antioxidant Activity of Tea (Camellia sinensis) Infected with Exobasidium vexans by Applying UPLC-MS/MS-Based Widely Targeted Metabolome and Biochemical Analysis’, Phytopathology, 114(1), pp. 164–176. DOI: https://doi.org/10.1094/PHYTO-03-23-0105-R
  73. Zong, J.F. et al. (2025) ‘Two New Triterpenoid Saponins with Antifungal Activity from Camellia sinensis Flowers’, International Journal of Molecular Sciences, 26(3). DOI: https://doi.org/10.3390/ijms26031147

Last update:

No citation recorded.

Last update:

No citation recorded.