DOI: https://doi.org/10.14710/genres.v1i2.10953

Phytosome as Cytotoxic Agent Delivering System : A Review

*Widyandani Sasikirana scopus publons  -  Pharmacy Study Program, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Eva Annisaa'  -  Pharmacy Study Program, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Nuraini Ekawati orcid  -  Prodi Farmasi, Fakultas Kedokteran Universitas Diponegoro, Indonesia
Received: 23 May 2021; Revised: 14 Jul 2021; Accepted: 16 Jul 2021; Available online: 14 Sep 2021; Published: 31 Oct 2021.
Open Access Copyright 2021 Generics: Journal of Research in Pharmacy

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Abstract

Along with the rapid development of herbal medicine formulas, an appropriate drug delivery system is needed to increase its bioavailability. One of them was used the phytosome. As a delivery system, it was known to be able to increase the bioavailability of phytomedicine by increasing the permeability of herbal compounds on cell membranes so the absorption of the compound will be increased. In its development, the phytosome formula was effective for delivering cytotoxic agent compounds, such as quercetin, diosgenin, icariin, tocopherol, and others. Besides, some of these formulas have also been commercialized and patented. The effectiveness and ease of manufacture have made phytosomes a promising drug delivery system in the development of cytotoxic drugs.

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Funding: Universitas Diponegoro under contract 233-75/UN7.6.1/PP/2020

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Language : EN
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