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Phytosome as Cytotoxic Agent Delivering System : A Review

*Widyandani Sasikirana scopus publons  -  Pharmacy Study Program, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Eva Annisaa'  -  Pharmacy Study Program, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Nuraini Ekawati orcid  -  Prodi Farmasi, Fakultas Kedokteran Universitas Diponegoro, Indonesia
Received: 23 May 2021; Revised: 14 Jul 2021; Accepted: 16 Jul 2021; Available online: 14 Sep 2021; Published: 31 Oct 2021.
Open Access Copyright 2021 Generics: Journal of Research in Pharmacy

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Abstract

Along with the rapid development of herbal medicine formulas, an appropriate drug delivery system is needed to increase its bioavailability. One of them was used the phytosome. As a delivery system, it was known to be able to increase the bioavailability of phytomedicine by increasing the permeability of herbal compounds on cell membranes so the absorption of the compound will be increased. In its development, the phytosome formula was effective for delivering cytotoxic agent compounds, such as quercetin, diosgenin, icariin, tocopherol, and others. Besides, some of these formulas have also been commercialized and patented. The effectiveness and ease of manufacture have made phytosomes a promising drug delivery system in the development of cytotoxic drugs.

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Funding: Universitas Diponegoro under contract 233-75/UN7.6.1/PP/2020

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  1. Lestari, Ayu., Anwar, Effionora., Harahap, Yahdiana. Design and Formulation Quercetin Formula In The Phytosome System as Novel Drug Delivery. International Journal of ChemTech Research, 2017, 10(06) : 148-151
  2. Karthivashan, Govindarajan., Masarudin, Mas Jaffri ., Kura, Aminu Umar ., Abas, Faridah Abas., Fakuraz, Sharida. Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique. International Journal of Nanomedicine.2016
  3. Rasaie, Solmaz ., Ghanbarzadeh, Saeed ., Mohammadi, Maryam., Hamishehkar, Hamed. Nano Phytosomes of Quercetin: A Promising Formulation for Fortification of Food Products with Antioxidants, , Pharmaceutical sciences, 2014, 20, 96-101
  4. Ajazuddin, S.Saraf., Review : Aplication of novel drugs delivery system for herbal formulations. Fitoterapia 81 (2020) 680-689
  5. Pawar, H.A., Bhangale, B.D. Phytosome as a Novel Biomedicine: A Microencapsulated Drug Delivery System. J Bioanal Biomed 2015, 7:1DOI: 10.4172/1948-593X.1000116
  6. Kumar, Arun; Kumar, Bimlesh; Singh, Sachin Kumar; Kaur, Barinder; Singh, Surabh. A Review On Phytosomes : Novel Approach For Herbal Phytochemicals. Asian Journal Of Pharmaceuticwl and Clinical Research. Vol 10, Issue 10, 2017, 41-47
  7. Kumar,Sudhir., Baldi, Ashish., Sharma, Dinesh Kumar. Phytosomes: A Modernistic Approach for Novel Herbal Drug Delivery Enhancing Bioavailability and Revealing Endless Frontier of Phytopharmaceuticals, 2020, J Develop Drugs, Vol. 9 Iss. 2 No: 195
  8. Bhavesh Shah., S. B. Puranik., Raghuchandan H S. Preparation and Evaluation of Curcumin Phytosomes ,International Journal of Pharmacy & Pharmaceutical Research. Ijppr.Human, 2020; Vol. 17 (4): 767-792.;
  9. Telange, Darshan R.; Patin, Arun T.; Pethe, Anil M.; Fegade, Harshal; Anand, Sridhar; and Dave, Vivek S. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. European Journal of Pharmaceutical Sciences, 2016, 108, 36-49
  10. Nabil A. Alhakamy; Usama A. Fahmy; Shaimaa M. Badr-Eldin; Osama A. A. Ahmed ; Hani Z. Asfour; Hibah M. Aldawsari; Mardi M. Algandaby; Basma G. Eid; Ashraf B. Abdel-Naim; Zuhier A. Awan; Nabil K. Alruwaili; Amir I. Mohamed. Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells. N. Pharmaceutics 2020, 12, 346; doi: 10.3390/pharmaceutics12040346
  11. Shahira F El-Menshawe; Adel A Ali; Mohamed A Rabeh; Nermeen M Khali.Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product, International Journal Of Nanomedicine, 2018, vol13: 307-318. https://doi.org/10.2147/IJN.S153429
  12. Singh R, Parpani S, Narke R, Chavan R. Phytosome: recent advance research for novel drug delivery system. Asian J Pharmaceut Res Health Care. 2014;2:15–29
  13. Rasaie, Solmaz., Ghanbarzadeh , Saeed., Mohammadi, Maryam., Hamishehkar, Hamed. Nano Phytosomes of Quercetin: A Promising Formulation for Fortification of Food Products with Antioxidants. Pharmaceutical sciences, 2014, 20, 96-101
  14. Singh R, Parpani S, Narke R, Chavan R. Phytosome: recent advance research for novel drug delivery system. Asian J Pharmaceut Res Health Care. 2014;2:15–29
  15. Shalini, Sharma., Kumar, Roy Ram., Birenda, Shrivastava. Antiproliferative effect of Phytosome complex of methanol extract Terminalia Arjuna bark on Human Breast Cancer Cell line (MCF-7). Int. J. Drug Dev. & Res., January-March 2015, 7 (1): 173-182. ISSN 0975-9344
  16. Liang Xu; Dekang Xu; , Ziying Li; Yu Gao; Haijun Chen. Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells 2019. J. Nanotechnol. 2019, 10, 1933-1942. doi: 10.3762/bjnano.10.189
  17. Patil, Swati., Ayare, Priyanka. Carica Papaya : formulatiom and Evaluation of new dosage form design. International Journal of Pharmaceutical Sciences and Research. 2017, ISSN : 0975-8232
  18. Yang Li; Hongjie Wu; Mengmeng Jia; Fei Cui; Jinyan Lin; Xiangrui Yang; Yange Wang; Lingfeng Dai; Zhenqing Hou.Therapeutic Effect of Folate-Targeted and PEGylated Phytosomes Loaded with a Mitomycin C−Soybean Phosphatidyhlcholine Complex. Mol. Pharmaceutics 2014, 11, 3017-3026. dx.doi.org/10.1021/mp5001873
  19. Sundaraganapathy; Leena P N. Development and Evaluation of Anti-Cancer Activity of Phytosome Formulated from the Root Extract of Clerodendron Paniculatum Linn. 2016. International Journal of Pharmacognosy and Phytochemical Research 2016; 8(11); 1778-1781. ISSN : 0975-4873
  20. Nazeer, Abdul Azeez; Veeraiyan, Sivapriya; Vijaykumar, Sudarshana Deepa. Anti-cancer Potency and Sustained Release Of Phytosomal Diallyl Disulfide Containing Methanolic Allium sativum Extract against Breast cancer. International Research Journal Of Pharmacy. 2017, 8 (8)
  21. Alhakamy, Nabil A; Fahmy, Usama A; Badr-Eldin, Shaimaa M; Ahmed, Osama A.A; Asfour, Hani Z; Aldawsari, Hibah M; Algandaby, Mardi M; Eid, Basma G; Abdel-Naim, Ashraf B; Awan, Zuhier A; Alwuraili, Nabil K; and Mohamed, Amir I. Optimized Icariim Phytosomes Exhibit Enhaced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells. Pharmaceutics 2020, 12, 346
  22. Alhakamy, Nabil A; Badr-Eldin, Shaimaa M; Fahmy, Usama A; Alruwaili, Nabil K; Awan, Zuhier A; Caruso, Giuseppe; Alfaleh, Mohamed A; Alaofi, Ahmed L; Arif, Faris O; Ahmed, Osama A.A; Alghaiith, Adel F. Thymoquinon-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells. Pharmaceutics, 2020, 12, 761
  23. D. Galloa, S. Giacomellia, C. Ferlinia, G. Raspaglioa, P. Apollonioa, S. Prisleia, A. Rivab, P. Morazzonib, E. Bombardellib, G. Scambia. Antitumour activity of the silybin phosphatidylcholine complex against human ovarian cancer. Eur. J. Cancer, 2003, 39, 2403–2410
  24. Narges Mahmoodi, Nasrin Motamed, Seyed Hassan Paylakhi. The Comparison of The Effects of Silybin and Silybin-Phosphatidylcholine on Viability and ESR Expression in Human Breast Cancer T47d cell line. Cell J., 2014; 16(3):299– 308
  25. Mehdi Sabzichi, Hamed Hamishehkar, Fatemeh Ramezani, Simin Sharifi, Maryam Tabasinezhad, Mohammadbagher Pirouzpanah1, Parisa Ghanbari, Nasser Samadi. Luteolinloaded phytosomes sensitize human breast carcinoma MDAMB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pacific J. Cancer Prev., 2014; 15(13):5311– 5316
  26. Hou, Z; Li, Y; Huang Y; Zhpu C; Lin J; Wang Y; et al. Phytosome Loaded with Mitomycin C-soybean Phosphatidylcholine Complex Developed for Drugs Delivery. Molecular Pharmaceutics, 2013, 10(1): 90-101
  27. Di Pierro, Fransesco. 2010. Compositions containing a phospholipid-curcumin complex and piperine as chemosensitizing agent. European Patent Application. EP. 2228062A1
  28. Singh, Anju; Ray, Avishikta; Mishra, Rakhi; Biswal, Pramod K; Yadav, Reenu; Ghatuary, Shailesh Kumar. Phyto-Phospholipid Complexes : Innovative Approach to Enhace the Bioavaibility and Therapeutic Efficacy of Herbal Extract. Pharmaceutical and Bioscience Journal, 2020 Vol. 8(4), 01-09
  29. Gs, Ravi; Charyulu R, Narayana; Dubey, Akhilesh; Hebbar, Srinivas; Mathias, Avril Candida. Phytosome: A Novel Molecular Nano Complex Between Phytomolecule and Phsopholipid as a Value added Herbl Drug Delivery System. Int. J.Pharm.Sci.Rev.Res, 51(1), July-August 2018; Article No. 14, Pages: 84-90
  30. Karimi, Nayer; Ghanbarzadeh, Babak; Hamishehkar, Hamed; Keivani, Fatemeh; Pezeshki, Akram; Gholian, Mohammad Mahdi. Phytosome and Liposome : The Beneficial Encapsulation System in Drug Delivery and Food Application. Applied Food Biotechnology, 2015, 2(3): 17-27

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