DOI: https://doi.org/10.14710/dimj.v6i1.25368

Risk Factors of Ectopic Pregnancy at Dr. Kariadi Hospital

*Kamila Zettira Zahwa  -  Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto No.13, Tembalang, Semarang, Jawa Tengah 50275, Indonesia
Yuli Trisetiyono orcid scopus  -  Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Diponegoro, Semarang Indonesia, Indonesia
M Besari Adi Pramono orcid scopus  -  Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Diponegoro, Semarang Indonesia, Indonesia
Julian Dewantiningrum orcid scopus  -  Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Diponegoro, Semarang Indonesia, Indonesia
Open Access Copyright (c) 2025 Diponegoro International Medical Journal
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Abstract

Background: Ectopic pregnancy lead to maternal death. There were several risk factors for ectopic pregnancy, including age, IUD, parity, history of ectopic pregnancy, history of pelvic and abdominal surgery, infertility, history of PID, history of abortion, and infertility treatment. This study aimed to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. Kariadi.

Objective: This study examines to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. Kariadi

Methods: This study was an analytical observational study with case control design consisted of 134 samples, divided into ectopic pregnancy (n=67) and threatened abortion as controls (n=67), collected from patient medical records from 2019 – 2024 using purposive sampling. Data analysis was carried out using bivariate analysis with Chi Square & Fisher Exact Test and multivariate analysis with Logistic Regression Test.

Results: There were correlation between history of ectopic pregnancy (p = 0,034), history of abortion (p = 0,002), and infertility (p = 0,009) with ectopic pregnancy. Other variables didn’t have significant relationship with ectopic pregnancy (p>0,05). Two risk factors were identified for ectopic pregnancy: history of abortion (p = 0,001; aOR = 3,516; 95% CI 1,632 – 7,577) and infertility (p = 0,005; aOR = 2,913; 95% CI 1,387 – 6,119).

Conclusion: There were correlation between history of ectopic pregnancy, history of abortion, and infertility with ectopic pregnancy, while other variables were not related to ectopic pregnancy. History of threatened abortion and infertility were risk factors for ectopic pregnancy.

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Risk Factors of Ectopic Pregnancy at Dr. Kariadi Hospital
Subject case control; ectopic pregnancy; history of abortion; infertility; risk factor
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Keywords: case control; ectopic pregnancy; history of abortion; infertility; risk factor

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Section: Original Research Article
Language : EN
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  6. Awadalla Abdelwahid S, Hajar Suliman Ibrahim A, Kabbashi Mohammed Adam H, Ibtehal Jaffer Youssef A, Mohamed Abdalla Elamin A, Abdallah Omer Elzein E, et al. Ectopic Pregnancy Risk Factors Presentation and Management Outcomes. Clinical Journal of Obstetrics and Gynecology. 2023;6:143–9
  7. Li C, Zhao WH, Meng CX, Ping H, Qin GJ, Cao SJ, et al. Contraceptive use and the risk of ectopic pregnancy: A multi-center case-control study. PLoS One. 2014;9:1–17
  8. Moini A, Hosseini R, Jahangiri N, Shiva M, Akhoond MR. Risk factors for ectopic pregnancy: A case-control study. Journal of Research in Medical Sciences. 2014;19:844–9
  9. Mahajan N, Raina R, Sharma P. Risk Factors for Ectopic Pregnancy: A Case-Control Study in Tertiary Care Hospitals of Jammu and Kashmir. Iberoamerican Journal of Medicine. 2021;3:293–9
  10. Pradana MFHR, Trisetiyono Y, Hariyana B, Pramono MBA. Factors Related to Ectopic Pregnancy in RSUD R.A Kartini Jepara. Diponegoro Medical Journal. 2021;10:241–5
  11. Triana A. Hubungan Umur dan Paritas Ibu Hamil dengan Kejadian Kehamilan Ektopik Terganggu di RSUD Arifin Achmad Pekanbaru. Journal of Health Sciences. 2018;11:183–7
  12. Lavinia Cozlea A, Előd Élthes E, Török, Emil Capîlna M. Clinical presentation, risk factors and management of ectopic pregnancy: A case-control study. Clin Exp Obstet Gynecol. 2019;46:914–9
  13. Yadav A, Prakash A, Sharma C, Pegu B, Saha M. Trends of ectopic pregnancies in Andaman and Nicobar Islands. Int J Reprod Contracept Obstet Gynecol. 2017;6:15–9
  14. Pemaron IBM, Bandem IKMP, Seputra DKA. The relationship between age and parity of pregnant women with the incidence of disrupted ectopic pregnancy at Wangaya hospital. International Journal of Advances in Medicine. 2022;10:16–8
  15. Yadav D, Bhati I, Bhati BS. Ectopic pregnancy: a comprehensive analysis of risk factors and management. Int J Reprod Contracept Obstet Gynecol. 2016;5:2723–7
  16. Ramadhan IA. Hubungan Usia dan Paritas terhadap Kejadian Kehamilan Ektopik Terganggu. [Semarang]: Universitas Islam Sultan Agung; 2022
  17. ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy. Obstetrics and gynecology. 2018;131:91–103
  18. Schultheis P, Montoya MN, Zhao Q, Archer J, Madden T, Peipert JF. Contraception and ectopic pregnancy risk: a prospective observational analysis. Am J Obstet Gynecol. 2021;224:228–9
  19. Arifuddin A. Hubungan Paritas dan Umur Ibu Terhadap Kejadian Kehamilan Ektopik Terganggu (KET) di RSUD Syekh Yusuf Gowa Tahun 2018. Jurnal Kesehatan Delima Pelamonia. 2018;2:87–92
  20. Wang X, Huang L, Yu Y, Xu S, Lai Y, Zeng W. Risk factors and clinical characteristics of recurrent ectopic pregnancy: A case–control study. Journal of Obstetrics and Gynaecology Research. 2020;46:1098–103
  21. Zhang D, Shi W, Li C, Yuan JJ, Xia W, Xue RH, et al. Risk factors for recurrent ectopic pregnancy: a case–control study. BJOG. 2016;123:82–9
  22. Parashi S, Moukhah S, Ashrafi M. Main risk factors for ectopic pregnancy: A case-control study in a sample of Iranian women. Int J Fertil Steril. 2014;8:147–54
  23. Arain FR, Habib LA, Alharthi HA, Elsayed TH, Alhumaidi DA, AlHarthi LA, et al. Appendectomy as a risk factor for ectopic pregnancy in Taif city. World Family Medicine/Middle East Journal of Family Medicine. 2020;18:31–6
  24. Hurrell A, Reeba O, Funlayo O. Recurrent ectopic pregnancy as a unique clinical sub group: a case control study. Springerplus. 2016;5
  25. Rombauts L, McMaster R, Motteram C, Fernando S. Risk of ectopic pregnancy is linked to endometrial thickness in a retrospective cohort study of 8120 assisted reproduction technology cycles. Human Reproduction. 2015;30:2846–52
  26. Mindjah YAA, Essiben F, Foumane P, Dohbit JS, Mboudou ET. Risk factors for ectopic pregnancy in a population of Cameroonian women: A case-control study. PLoS One. 2018;13
  27. He D, Wang T, Ren W. Global burden of pelvic inflammatory disease and ectopic pregnancy from 1990 to 2019. BMC Public Health. 2023;23
  28. Jennings LK, Krywko DM. Pelvic Inflammatory Disease [Internet]. StatPearls. 2023 [cited 2024 Jan 6]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499959/
  29. Kaplan S, Kaplan E, Türkler C, Kırıcı P, Bülbül M. Recurrent ectopic pregnancy risk factors and clinical features: a case-control study in Turkey. Journal of Health Inequalities. 2021;7:57–62
  30. Kathpalia SK, Kapoor K, Sharma A. Complications in pregnancies after in vitro fertilization and embryo transfer. Med J Armed Forces India. 2016;72:211–4
  31. Weiss A, Beck-Fruchter R, Golan J, Lavee M, Geslevich Y, Shalev E. Ectopic pregnancy risk factors for ART patients undergoing the GnRH antagonist protocol: A retrospective study. Reproductive Biology and Endocrinology. 2016;14
  32. Anzhel S, Mäkinen S, Tinkanen H, Mikkilä T, Haltia A, Perheentupa A, et al. Top-quality embryo transfer is associated with lower odds of ectopic pregnancy. Acta Obstet Gynecol Scand. 2022;101:779–86

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