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RISK FACTORS FOR SMELL AND TASTE DISORDER IN MILD AND MODERATE COVID-19 IN SEMARANG

*Anna Mailasari Kusuma Dewi  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University Semarang, Indonesia, Indonesia
Ismiar Astika  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University Semarang, Indonesia, Indonesia
Farokah Farokah  -  Department of Otorhinolaryngology-Head and Neck Surgery, Kariadi Hospital, Semarang, Indonesia, Indonesia
kanti yunika  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University Semarang, Indonesia, Indonesia
Dwi Marliyawati  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University Semarang, Indonesia, Indonesia
Open Access Copyright (c) 2023 Diponegoro International Medical Journal
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

ABSTRACK 

Background: COVID-19 can make smell and taste disorder due to Angitensin Converting Enzyme 2 (ACE2) binding to olfactory tractus and taste bud that affected by gender, age, comorbid and COVID-19 severerity.

Aim: To analyze age, gender, comorbid and COVID-19 severity as risk factor for smell and or taste disorder in mild and moderate Covid -19 patient in Semarang

Methods: Observational research used cross section design. Sample is COVID-19 patients age >10 years old with severity mild and moderate nonhospitalize that record on Health Center of Semarang City June – July 2021. Sampling metode using purposive sampling with secondary data. Association between variable analyze using Chi square or Fisher exact test, multivariate analyze with logistic regression.

Results: Research on 4337 people, 2.0% smell disorder and 0.5% taste disorder. Prevalence COVID-19 mostly on women 50.5% and adult (20-60 years old) 82.5%. Risk factor gender, age and COVID-19 severity is not associated with smell and taste disorder on COVID-19 patients (p<0.05). Chronic liver disease as a risk factor only for smell disorder on COVID-19 patients (p 0.04, CI 3.029-786.993, RP 48.828). 

Conclusion: Chronic liver disease is a comorbid as a risk factor for smell disorder ini COVID-19 patients at Semarang. age, gender and other comorbid not as a risk factor for smell and or taste disorder.

 

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Keywords: smell disorder, taste disorder, COVID-19
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  1. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. The Lancet infectious diseases. 2020;20(5):533-4
  2. Meini S, Suardi LR, Busoni M, Roberts AT, Fortini A. Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. European archives of oto-rhino-laryngology. 2020;277(12):3519-23
  3. Ninchritz-Becerra E, Soriano-Reixach MM, Mayo-Yánez M, Calvo-Henríquez C, de Apodaca PM-R, Saga-Gutiérrez C, et al. Subjective evaluation of smell and taste dysfunction in patients with mild COVID-19 in Spain. Medicina Clínica (English Edition). 2021;156(2):61-4
  4. Lee Y, Min P, Lee S, Kim S-W. Prevalence and duration of acute loss of smell or taste in COVID-19 patients. Journal of Korean medical science. 2020;35(18)
  5. Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID‐19 patients: single‐center experience on 72 cases. Head & neck. 2020;42(6):1252-8
  6. Al-Zaidi HMH, Badr HM. Incidence and recovery of smell and taste dysfunction in COVID-19 positive patients. The Egyptian Journal of Otolaryngology. 2020;36(1):1-6
  7. Sierpiński R, Pinkas J, Jankowski M, Zgliczyński WS, Wierzba W, Gujski M, et al. Gender differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders among 1,942 non-hospitalized patients with COVID-19. Pol Arch Intern Med. 2020;130:501-5
  8. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. The lancet. 2020;395(10229):1033-4
  9. Bai Y, Yao L, Wei T, Tian F, Jin D-Y, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. Jama. 2020;323(14):1406-7
  10. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England journal of medicine. 2020
  11. Liu W, Zhang QI, Chen J, Xiang R, Song H, Shu S, et al. Detection of Covid-19 in children in early January 2020 in Wuhan, China. New England Journal of Medicine. 2020;382(14):1370-1
  12. Sharma G, Volgman AS, Michos ED. Sex differences in mortality from COVID-19 pandemic: are men vulnerable and women protected? Case Reports. 2020;2(9):1407-10
  13. Yehia BR, Winegar A, Fogel R, Fakih M, Ottenbacher A, Jesser C, et al. Association of race with mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) at 92 US hospitals. JAMA network open. 2020;3(8):e2018039-e
  14. Ho FK, Celis-Morales CA, Gray SR, Katikireddi SV, Niedzwiedz CL, Hastie C, et al. Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ open. 2020;10(11):e040402
  15. Umnuaypornlert A, Kanchanasurakit S, Lucero-Prisno DE, III, Saokaew S. Smoking and risk of negative outcomes among COVID-19 patients: A systematic review and meta-analysis. Tobacco induced diseases. 2021;19
  16. Han AY, Mukdad L, Long JL, Lopez IA. Anosmia in COVID-19: mechanisms and significance. Chemical senses. 2020;45(6):423-8
  17. Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G, editors. Potential pathogenesis of ageusia and anosmia in COVID-19 patients2020
  18. Carrillo-Larco RM, Altez-Fernandez C. Anosmia and dysgeusia in COVID-19: A systematic review. Wellcome open research. 2020;5
  19. Qiu C, Cui C, Hautefort C. Olfactory and gustatory dysfunction as an early identifier of COVID-19 in adults and children: an international multicenter study. Otolaryngol Neck Surg 163 (4): 714–721. 2020
  20. Sehanobish E, Barbi M, Fong V, Kravitz M, Sanchez Tejera D, Asad M, et al. COVID-19-induced anosmia and ageusia are associated with younger age and lower blood eosinophil counts. American journal of rhinology & allergy. 2021;35(6):830-9
  21. Izquierdo-Domínguez A, Rojas-Lechuga MJ, Chiesa-Estomba C, Calvo-Henríquez C, Ninchritz-Becerra E, Soriano-Reixach M, et al. Smell and taste dysfunction in COVID-19 is associated with younger age in ambulatory settings: a multicenter cross-sectional study. J Investig Allergol Clin Immunol. 2020:346-57
  22. Mercante G, Ferreli F, De Virgilio A, Gaino F, Di Bari M, Colombo G, et al. Prevalence of taste and smell dysfunction in coronavirus disease 2019. JAMA Otolaryngology–Head & Neck Surgery. 2020;146(8):723-8
  23. Al-Ani RM, Acharya D. Prevalence of anosmia and ageusia in patients with COVID-19 at a primary health center, Doha, Qatar. Indian Journal of Otolaryngology and Head & Neck Surgery. 2020:1-7
  24. Mazzatenta A, Neri G, D'Ardes D, De Luca C, Marinari S, Porreca E, et al. Smell and taste in severe CoViD-19: self-reported vs. testing. Frontiers in medicine. 2020;7:589409
  25. Hasan MM, Tamanna NA, Jamal MN, Uddin MJ. The prevalence of olfactory dysfunction and its associated factors in patients with COVID-19 infection. MedRxiv. 2021
  26. Awalia MJ, Medyati NJ, Giay ZJ. Hubungan Umjur Dan Jenis Kelamin Dengan Stress Kerja Pada Perawat Di Ruang Rawat Inap RSUD Kwaingga Kabupaten Keerom. JISIP (Jurnal Ilmu Sosial Dan Pendidikan). 2021;5(2)
  27. Iriani D, Dewi AMK, Hariyati R, Santosa YI. Gangguan Penghidu dan Gangguan Pengecapan pada Kasus COVID 19: Prevalence, Onset, and Duration of Olfactory and Gustatory dysfunction on COVID 19 case. Medica Hospitalia: Journal of Clinical Medicine. 2022;9(2):141-6
  28. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet. 2020;395(10223):507-13
  29. Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, et al. Comorbidity and its impact on patients with COVID-19. SN comprehensive clinical medicine. 2020;2(8):1069-76
  30. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020;395(10223):497-506
  31. Printza A, Katotomichelakis M, Valsamidis K, Metallidis S, Panagopoulos P, Panopoulou M, et al. Smell and taste loss recovery time in COVID-19 patients and disease severity. Journal of Clinical Medicine. 2021;10(5):966
  32. Awwad AA, Abd Elhay OMM, Rabie MM, Awad EA, Kotb FM, Maghraby HM, et al. Impact of Systemic Diseases on Olfactory Function in COVID-19 Infected Patients. International journal of general medicine. 2022;15:5681
  33. Abdelmaksoud AA, Ghweil AA, Hassan MH, Rashad A, Khodeary A, Aref ZF, et al. Olfactory disturbances as presenting manifestation among Egyptian patients with COVID-19: Possible role of zinc. Biological trace element research. 2021;199(11):4101-8
  34. Derin S, Koseoglu S, Sahin C, Sahan M, editors. Effect of vitamin B12 deficiency on olfactory function2016: Wiley Online Library

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