DOI: https://doi.org/10.14710/dimj.v3i2.15191

The Association between Obstructive Sleep Apnea and Glycated Haemoglobin A1c (Hba1c) Level in Diabetes Mellitus Type II Patient

*Anna Mailasari Kusuma Dewi  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University/ Diponegoro National Hospital, Semarang, Indonesia, Indonesia
Peny Handayani  -  Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Diponegoro University/ Diponegoro National Hospital, Semarang, Indonesia, Indonesia
Devi Elvina Rachma  -  Department of Clinical Pathology, Faculty of Medicine, Diponegoro University/ Diponegoro National Hospital, Semarang, Indonesia, Indonesia
Edward Kurnia Setiawan Limijadi  -  Department of Clinical Pathology, Faculty of Medicine, Diponegoro University/ Diponegoro National Hospital, Semarang, Indonesia, Indonesia
Open Access Copyright (c) 2022 Diponegoro International Medical Journal
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Abstract

Abstract

 

Background: Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive episodes of upper airway collapse, apnea, and arousal during sleep. OSA and type 2 diabetes mellitus (T2DM) are common comorbid conditions. Haemoglobin A1c (HbA1c) is an approximation of an individual’s average blood glucose level for the prior two to three months, and therefore is considered to be a major index for monitoring glycaemic control in diabetic patients

Objective: This study aimed to examine the association between OSA and HbA1c levels in T2DM patients.

Methods: This was a cross-sectional study. The study assesses the association between OSA and HbA1c levels in 75 T2DM patients. OSA in the patient was asses with Epworth Sleepiness Scale (ESS) questionnaire. HbA1c values were obtained from the patient’s records. Data presented in mean ± SD, max, and min. Correlations analyses using Pearson correlation coefficient with p < 0.05 were considered statistically significant.

Results: A total of 75 T2DM has a mean BMI were 25.26 ± 48.31 kg/m2 with mean HbA1c levels of about 7.1 ± 0.19%. The mean ESS score was 5 ± 0.429. The very weak correlation between OSA and BMI was statistically significant, r = 0.213; p = 0.047. Meanwhile, a very weak correlation between OSA and HbA1c levels was not statistically significant, r = 0.137; p = 0.242

Conclusion: Among adults with T2DM, the correlation between OSA with HbA1c was not statistically significant

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Keywords: HbA1c; Obstructive sleep apnea; Type II diabetes mellitus

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Section: Original Research Article
Language : EN
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  1. Tehrani et al. Obstructive sleep apnoea and diabetes: an update. Curr Opin Pulm Med. 2013; 19 (6):631–8
  2. Mirrakhimov AE, Sooronbaev T, dan Mirrakhimov EM. Prevalence of obstructive sleep apnea in Asian adults: a systematic review of the literature. BMC Pulmonary Medicine 2013; 13:1-10. http://www.biomedcentral.com/1471-2466/13/10
  3. Marin-Oto M, Vincent EE, dan Marin JM. Long-term management of obstructive sleep apnea and its comorbidities. Multidisciplinary respiratory medicine. 2019; 14(21): 1-9.https//doi.org/10.1186/s40248-019-0186-3
  4. Tamura et al. Obstructive sleep apnea increase hemoglobin A1c levels regardless of glucose tolerance status. Sleep medicine. 2012; 13 (2012) 1050–5
  5. Kent BD et al. Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study. Eur Respir J 2014; 44: 130–9 | DOI: 10.1183/09031936.00162713
  6. Meenakshi N, Nagarjun S, Aruna Shanmuganathan, Ragulan. Correlation of apnea-hypopnea index severity with fasting blood sugars and HbA1C values in patients with metabolic syndrome. International Journal of Contemporary Medical Research 2020;7(3): C1-C5
  7. Kurosawa et al. Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes. Endocrine Journal. 2018; 65 (1): 121-7
  8. Somprasit C et al. High Pre-Pregnancy Body Mass Index and the Risk of Poor Obstetrics Outcomes among Asian Women Using BMI Criteria for Asians by World Health Organization Western Pacific Region (WPRO): A Large Cohort StudyJ Med Assoc Thai 2015; 98 (Suppl. 2): S1071-9
  9. Murakami Y et al. Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration Preventive Medicine. 2012; 54(2012): 38–41
  10. Lam et al. Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus. Chest, 2010, 138: 1101–7
  11. Priou et al. Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes. Diabetes Care. 2012; 35(2012): 1902–6
  12. Malik JA, Masoodi SR, Shoib S. Obstructive sleep apnea in Type 2 diabetes and impact of continuous positive airway pressure therapy on glycemic control. Indian J Endocr Metab 2017:21:106‑12
  13. Framnes SN and Arble DM. The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease.Obstructive Sleep Apnea and Metabolic Disease. 2018; 9 (440): 1-14
  14. PERKENI. Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia: PERKENI; Jakarta; 2019
  15. Grimaldi et al. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care, 2014, 37: 355–63
  16. Aronsohn et al. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am. J. Respir. Crit. Care Med., 2010, 181: 507–13
  17. Gottlieb DJ, dan Punjabi, NM. Diagnosis and Management of Obstructive Sleep Apnea A Review. JAMA. 2020; 323(14): 1389-97
  18. Tietjens JR et al. Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy. J Am Heart Assoc. 2019; 8: e010440: 1-13. DOI: 10.1161/JAHA.118.010440

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