DOI: https://doi.org/10.14710/dimj.v3i1.13944

Histological and Clinical Stage Profiles of Young-aged Breast Carcinoma

*Alda Vania Sugiarto Hadiyanto  -  Faculty of Medicine, Diponegoro University, Indonesia, Indonesia
Ika Pawitra Miranti  -  Department of Pathology Anatomy, Faculty of Medicine, Diponegoro University, Indonesia, Indonesia
Yan Wisnu Prajoko  -  Department of Surgery Science, Faculty of Medicine, Diponegoro University, Indonesia, Indonesia
Hermawan Istiadi  -  Department of Pathology Anatomy, Faculty of Medicine, Diponegoro University, Indonesia, Indonesia
Open Access Copyright (c) 2022 Diponegoro International Medical Journal
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Citation Format:
Abstract

Background: Breast cancer is the most common type of malignancy in women. Many studies report that the characteristics and prognosis of young-aged breast carcinoma are worse than in old age. Data on young-aged breast carcinoma in Indonesia is relatively lacking and always needs updates.

Objective: To determine the incidence and distribution based on histological profiles and clinical stage, as well as the association between molecular subtype with grade and clinical stage of young-aged breast carcinoma (<40 years old) at Dr. Kariadi General Hospital Center in 2018-2020.

Methods: This research was an observational descriptive study using medical records of young-aged breast carcinoma patients which were recorded at Dr. Kariadi General Hospital Center from 1st January 2018 until 31st December 2020. The data were processed with Microsoft Excel and SPSS.

Results: The results showed that there were 110 patients consisting of 25 people in 2018, 37 people in 2019, and 48 people in 2020. The most common histological and clinical stage was IBC-NST with 75 people (68,18%), Luminal B with 53 people (48,18%). grade II with 71 people (64,65%), and stage IV with 45 people (40,09%). There is a significant association between molecular subtype and grade (p=0.003). There is no significant association between molecular subtype and clinical stage (p=0.704).

Conclusion: The incidence of young-aged breast carcinoma at Dr. Kariadi General Hospital Center in 2018-2020 was increasing every year. The most common histological profiles and clinical stage during that period were IBC-NST, Luminal B, grade II, and stage IV. There is a significant association between molecular subtype and grade.

Keywords: Breast carcinoma, clinical stage, grade, histological type, molecular subtype, young age
Fulltext View|Download
Keywords: Breast carcinoma; clinical stage; grade; histological type; molecular subtype; young age

Article Metrics:

Article Info
Section: Original Research Article
Language : EN
Recent articles
Histological and Clinical Stage Profiles of Young-aged Breast Carcinoma Correlation between Hematologic Parameters and Asymptomatic Bacteriuria in the Full-Term Pregnant Patients in Dr. Kariadi Hospital, Semarang, Indonesia The Relationship Between Obstructive Sleep Apnea And Levels Of Depression And Anxiety In Young Adults More recent articles
  1. Global Cancer Observatory: Cancer Today [Internet]. Lyon, France: International Agency for Research on Cancer; c2020 [cited 2021 Feb 20]. Available from: https://gco.iarc.fr/today
  2. Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar 2013. Jakarta: Balitbang Kemenkes RI; 2013
  3. Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast cancer Dove Med Press. 2019; 11:151–64
  4. Partini PDO, Niryana IW, Adiputra PAT. Karakteristik kanker payudara usia muda di Subbagian Bedah Onkologi Rumah Sakit Umum Pusat Sanglah tahun 2014-2016. Intisari Sains Medis. 2018;9(1):76–9
  5. Stankov A, Bargallo-Rocha JE, Silvio A, Ramirez MT, Stankova-Ninova K, Meneses-Garcia A. Prognostic factors and recurrence in breast cancer: experience at the national cancer institute of Mexico. Int Sch Res Not. 2012;2012
  6. Assi HA, Khoury KE, Dbouk H, Khalil LE, Mouhieddine TH, El Saghir NS. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis. 2013;5(Suppl 1):S2
  7. WHO Classification of Tumours : Breast Tumours. 5th Ed. Lyon (France): International Agency for Research on Cancer; 2019
  8. Makki J. Diversity of breast carcinoma: histological subtypes and clinical relevance. Clin Med Insights Pathol. 2015;8:CPath. S31563
  9. Windarti I. Characteristic Of Breast Cancer In Young Women In H. Abdul Moeloek Hospital Bandar Lampung. Juke Unila. 2014;4(07)
  10. Al-Thoubaity FK. Molecular classification of breast cancer: A retrospective cohort study. Ann Med Surg. 2020;49:44–8
  11. Lian W, Fu F, Lin Y, Lu M, Chen B, Yang P, et al. The Impact of Young Age for Prognosis by Subtype in Women with Early Breast Cancer. Sci Rep. 2017;7(1):11625
  12. Christgen M, Länger F, Kreipe H. Histological grading of breast cancer. Pathologe. 2016 Jul;37(4):328–36
  13. Hartaningsih NMD, Sudarsa IW. Kanker Payudara Pada Wanita Usia Muda di Bagian Bedah Onkologi Rumah Sakit Umum Pusat Sanglah Denpasar Tahun 2002–2012. E-Jurnal Medika Udayana. 2014
  14. Koh J, Kim MJ. Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage. Korean J Radiol. 2019;20(1):69–82
  15. Mousavi-Jarrrahi SH, Kasaeian A, Mansori K, Ranjbaran M, Khodadost M, Mosavi-Jarrahi A. Addressing the Younger Age at Onset in Breast Cancer Patients in Asia: An Age-Period-Cohort Analysis of Fifty Years of Quality 50 Data from the International Agency for Research on Cancer. Ferrandina G, Hansen O, editors. ISRN Oncol. 2013;2013:429862
  16. Fan L, Goss PE, Strasser-Weippl K. Current Status and Future Projections of Breast Cancer in Asia. Breast Care. 2015;10(6):372–8
  17. American Cancer Society. Global Cancer Facts & Figures. 4th Edition. Atlanta: American Cancer Society; 2018
  18. Christoper A. Angka kejadian wanita usia muda yang menderita kanker payudara di RSUP Haji Adam Malik Medan tahun 2013-2017[disertasi]. Medan (Indonesia): Universitas Sumatera Utara; 2018
  19. Erić I, Petek Erić A, Kristek J, Koprivčić I, Babić M. Breast cancer in young women: pathologic and immunohistochemical features. Acta Clin Croat. 2018;57(3):497–502
  20. American Cancer Society. Breast Cancer Facts & Figures 2019-2020. Atlanta: American Cancer Society; 2019
  21. Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 2018;5(2):77–106
  22. Bustreo S, Osella-Abate S, Cassoni P, Donadio M, Airoldi M, Pedani F, et al. Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: a large case series study with a long-term follow-up. Breast Cancer Res Treat. 2016;157(2):363–71
  23. Lee MK, Varzi LA, Chung DU, Cao M, Gornbein J, Apple SK, et al. The Effect of Young Age in Hormone Receptor Positive Breast Cancer. Rohrmann S, editor. Biomed Res Int. 2015;2015:325715
  24. Fredholm H, Magnusson K, Lindström LS, Tobin NP, Lindman H, Bergh J, et al. Breast cancer in young women and prognosis: How important are proliferation markers? Eur J Cancer. 2017;84:278–89
  25. Kolečková M, Kolář Z, Ehrmann J, Kořínková G, Trojanec R. Ageassociated prognostic and predictive biomarkers in patients with breast cancer. Oncol Lett. 2017;13(6):4201–7
  26. Ayuza M, Harahap WA, Rustam R, Nindrea RD. Faktor yang Berpengaruh Terhadap Disease Free Survival dan Overall Survival pada Pasien Kanker Payudara Usia Muda di Kota Padang Tahun 2008 - 2018. J Kesehat Andalas. 2020;9(1)
  27. Firasi AA, Yudhanto E. Hubungan usia terhadap derajat diferensiasi kanker payudara pada wanita. Diponegoro Med J (Jurnal Kedokt Diponegoro). 2016;5(4):327–36
  28. Tjokrowidjaja A, Lee CK, Houssami N, Lord S. Metastatic breast cancer in young women: a population-based cohort study to describe risk and prognosis. Intern Med J. 2014;44(8):764–70
  29. Bakkach J, Mansouri M, Derkaoui T, Loudiyi A, Fihri M, Hassani S, et al. Clinicopathologic and prognostic features of breast cancer in young women: a series from North of Morocco. BMC Womens Health. 2017;17(1):106
  30. Lee H-B, Han W. Unique features of young age breast cancer and its management. J Breast Cancer. 2014;17(4):301–7
  31. Djatmiko A, Octovionus J, Fortunata N. Profil cancer delay pada kasus kanker payudara di RS Onkologi Surabaya. Indones J Cancer. 2013;7(2)
  32. Setyawati Y, Rahmawati Y, Widodo I, Ghozali A, Purnomosari D. The Association between Molecular Subtypes of Breast Cancer with Histological Grade and Lymph Node Metastases in Indonesian Woman. Asian Pac J Cancer Prev. 2018;19(5):1263–8
  33. Ovcaricek T, Frkovic SG, Matos E, Mozina B, Borstnar S. Triple negative breast cancer - prognostic factors and survival. Radiol Oncol. 2011;45(1):46–52
  34. Tečić Vuger A, Šeparović R, Vazdar L, Pavlović M, Lepetić P, Šitić S, et al. Characteristics And Prognosis Of Triple-Negative Breast Cancer Patients: A Croatian Single Institution Retrospective Cohort Study. Acta Clin Croat. 2020;59(1):97–108
  35. Inwald EC, Klinkhammer-Schalke M, Hofstädter F, Zeman F, Koller M, Gerstenhauer M, et al. Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry. Breast Cancer Res Treat. 2013;139(2):539–52

Last update:

No citation recorded.

Last update:

No citation recorded.