DOI: https://doi.org/10.9767/bcrec.13.1.963.82-88

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

1Department of Chemistry, Govt., Degree College Boys, Sopore Jammu & Kashmir, 193201, India

2Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, J&K, India

Received: 24 Feb 2017; Revised: 8 Aug 2017; Accepted: 23 Aug 2017; Published: 2 Apr 2018; Available online: 22 Jan 2018.
Open Access Copyright (c) 2018 by Authors, Published by BCREC Group under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract

A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst. The recyclable heterogeneous Cu(II)-Clay catalyst exhibited a remarkable activity for the title reaction without any additives. An assortment of structurally diverse 2H-indazoles were prepared in good to excellent yields from easily available starting materials by using this protocol. The Cu(II)-Clay catalyst was characterized by using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Brunauer-Emmett-Teller (BET) techniques.  

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Keywords: 2H-indazoles; copper catalyst; multicomponent reaction; green synthesis; neat protocol

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Language : EN
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Last update: 2021-08-06 01:26:10

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