Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

*Bashir Ahmad Dar  -  Department of Chemistry, Govt., Degree College Boys, Sopore Jammu & Kashmir, 193201, India
Syed Wasim Safvi  -  Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, J&K, India
Masood Ahmad Rizvi  -  Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, J&K, India
Received: 24 Feb 2017; Revised: 8 Aug 2017; Accepted: 23 Aug 2017; Published: 2 Apr 2018; Available online: 22 Jan 2018.
Open Access Copyright (c) 2018 Bulletin of Chemical Reaction Engineering & Catalysis
License URL: http://creativecommons.org/licenses/by-sa/4.0

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Abstract

A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst. The recyclable heterogeneous Cu(II)-Clay catalyst exhibited a remarkable activity for the title reaction without any additives. An assortment of structurally diverse 2H-indazoles were prepared in good to excellent yields from easily available starting materials by using this protocol. The Cu(II)-Clay catalyst was characterized by using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Brunauer-Emmett-Teller (BET) techniques.  Copyright © 2018 BCREC Group. All rights reserved

Received: 24th February 2017; Revised: 8th August 2017; Accepted: 23rd August 2017; Available online: 22nd January 2018; Published regularly: 2nd April 2018

How to Cite: Dar, B.A., Safvi, S.W., Rizvi, M.A. (2018). Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles. Bulletin of Chemical Reaction Engineering & Catalysis, 13 (1): 82-88 (doi:10.9767/bcrec.13.1.963.82-88)

 

Keywords: 2H-indazoles; copper catalyst; multicomponent reaction; green synthesis; neat protocol

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Section: Original Research Articles
Language: EN
In 2018: BCREC Volume 13 Issue 1 Year 2018 (SCOPUS and Web of Science Indexed, April 2018)
Statistics: 2989 465
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