Clean 3,4-Dihydropyrimidones Synthesis via Biginelli Reaction over Supported Molybdenum: Structural and Textural Characteristic of αMoO3

*Ouzna Kheffache  -  Laboratoire de Chimie du Gaz Naturel, Faculté de Chimie, Université des Sciences et de la Technologie Houari Boumediène, Algeria
Cristina Lopez-Olmos  -  Instituto de Catálisis y Petroleoquímica, Spain
Inmaculada Rodriguez-Ramos  -  Instituto de Catálisis y Petroleoquímica, Spain
Ouiza Cherifi  -  Laboratoire de Chimie du Gaz Naturel, Faculté de Chimie, Université des Sciences et de la Technologie Houari Boumediène, Algeria
Received: 5 Jul 2020; Revised: 14 Aug 2020; Accepted: 15 Aug 2020; Published: 28 Dec 2020; Available online: 15 Sep 2020.
Open Access Copyright (c) 2020 Bulletin of Chemical Reaction Engineering & Catalysis
License URL: http://creativecommons.org/licenses/by-sa/4.0

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Abstract

A one-pot three-component synthesis of dihydropyrimidinones (DHPMs) via Biginelli reaction was carried out at 100 °C using benzaldehyde, ethyl acetoacetate and urea as reactants, in the presence of ethanol and free solvent, in heterogeneous catalytic medium. The Mo (30 wt%) metal oxides (Al2O3, SiO2 or MgO) used catalysts were prepared by sol-gel, impregnation and microemulsion methods and characterized by X-Ray Diffraction (XRD), Fourier Transform Infra Red (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray (EDX), Nitrogen Adsorption - Brunauer-Emmett-Teller (BET), and NH3-Temperature Programmed Desorption (TPD) methods. The Mo-SiO2 sample prepared by the sol-gel method exhibited the highest DHPM yield (87%), in free solvent with a reaction time of 30 min. The high efficiency, in the Biginelli reaction, of the Mo-SiO2 catalyst is due to its structural, textural and acid properties. Highly dispersed αMoO3 species of orthorhombic structure having a high contribution of strong acidic sites would be the active species in the Biginelli synthesis  Copyright © 2020 BCREC Group. All rights reserved

 

Keywords: Heterogeneous catalysis; Biginelli reaction; Green chemistry; αMoO3; SiO2
Funding: Ministère de l'Enseignement Supérieur et de la Recherche Scientifique (MESRS), Algérie under contract Spanish Agencia Estatal de Investigación (AEI) y el Fondo Europeo de Desar

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Last update: 2021-01-18 20:01:08

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