DOI: https://doi.org/10.9767/bcrec.14.3.4574.551-558

Isatin Aldazines Synthesis using A Proton Exchanged Algerian Montmorillonite Clay as Acid Eco-friendly Catalyst

1Laboratoire de Chimie Fine, Faculté des Sciences Exactes et Appliquées, Université Oran1, BP-1524-Menouar, 31000 - Oran, Algeria

2Laboratoire de Chimie Organique et des Substances Naturelles, Faculté des Sciences Exactes et Informatiques, Université Ziane Achour, Djelfa, Algeria

Received: 28 Mar 2019; Revised: 14 May 2019; Accepted: 21 May 2019; Available online: 30 Sep 2019; Published: 1 Dec 2019.
Editor(s): Hadi Nur
Open Access Copyright (c) 2019 by Authors, Published by BCREC Group under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract

An efficient and easy procedure is developed for the synthesis of isatin aldazines or bis-Schiff bases of isatin, catalyzed by a proton exchanged Algerian montmorillonite clay (MMT-H+) as green catalyst. The products were obtained in two catalyzed steps under conventional heating in ethanol. Isatin-3-hydrazone obtained from the reaction of isatin with hydrazine monohydrate reacts in the second step with the appropriate aromatic aldehydes to give the desired products in good yields. The main advantages of using this protonated solid non-toxic catalyst in this synthesis are its availability and low cost, the simplicity of its use, the recycling possibilities without significant loss of its catalytic activity and its environmentally benign process. 

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Keywords: Montmorillonite-H+; Isatine; Isatin-3-hydrazone; bis-Schiff bases; Isatin Aldazines; Green catalyst.
Funding: Université Oran1; University of Djelfa; DGRSDT MESRS algerian ministry

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Section: Original Research Articles
Language : EN
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